CZ280922B6 - Kyseliny alfa-oxopyrrolo/2,3-b/indoloctové a jejich estery, amidy a analogy, způsob jejich přípravy a jejich použití jako léčiva - Google Patents
Kyseliny alfa-oxopyrrolo/2,3-b/indoloctové a jejich estery, amidy a analogy, způsob jejich přípravy a jejich použití jako léčiva Download PDFInfo
- Publication number
- CZ280922B6 CZ280922B6 CS911429A CS142991A CZ280922B6 CZ 280922 B6 CZ280922 B6 CZ 280922B6 CS 911429 A CS911429 A CS 911429A CS 142991 A CS142991 A CS 142991A CZ 280922 B6 CZ280922 B6 CZ 280922B6
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- CZ
- Czechia
- Prior art keywords
- group
- carbon atoms
- acetic acid
- formula
- indole acetic
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 86
- QOPBEBWGSGFROG-UHFFFAOYSA-N 2-(1h-indol-2-yl)acetic acid Chemical compound C1=CC=C2NC(CC(=O)O)=CC2=C1 QOPBEBWGSGFROG-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
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- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 9
- 125000000304 alkynyl group Chemical group 0.000 claims abstract description 7
- 125000002541 furyl group Chemical group 0.000 claims abstract description 7
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 7
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52462790A | 1990-05-17 | 1990-05-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS142991A3 CS142991A3 (en) | 1992-01-15 |
| CZ280922B6 true CZ280922B6 (cs) | 1996-05-15 |
Family
ID=24090019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS911429A CZ280922B6 (cs) | 1990-05-17 | 1991-05-15 | Kyseliny alfa-oxopyrrolo/2,3-b/indoloctové a jejich estery, amidy a analogy, způsob jejich přípravy a jejich použití jako léčiva |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0457318B1 (en16) |
| JP (1) | JPH0826024B2 (en16) |
| KR (2) | KR100215615B1 (en16) |
| AR (1) | AR247888A1 (en16) |
| AT (1) | ATE141273T1 (en16) |
| AU (1) | AU634380B2 (en16) |
| CA (1) | CA2042737A1 (en16) |
| CZ (1) | CZ280922B6 (en16) |
| DE (1) | DE69121299T2 (en16) |
| DK (1) | DK0457318T3 (en16) |
| ES (1) | ES2094768T3 (en16) |
| FI (1) | FI96689C (en16) |
| GR (1) | GR3021043T3 (en16) |
| HU (1) | HU210179B (en16) |
| IE (1) | IE76318B1 (en16) |
| IL (1) | IL98162A (en16) |
| MX (2) | MX25777A (en16) |
| NO (1) | NO177710C (en16) |
| NZ (2) | NZ238151A (en16) |
| PL (1) | PL290273A1 (en16) |
| PT (1) | PT97688B (en16) |
| ZA (1) | ZA913711B (en16) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4983616A (en) * | 1990-02-01 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds |
| AU634654B2 (en) * | 1990-05-11 | 1993-02-25 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments |
| AU649953B2 (en) * | 1990-06-27 | 1994-06-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydroisoquinolinylcarbamates of 1,2,3,3A,8,8A-hexahydro-1,3A,8-trimethylpyrrolo(2,3-B)indole |
| US7229986B2 (en) | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
| WO2010027334A1 (en) | 2008-09-03 | 2010-03-11 | Nanyang Technological University | Novel tricyclic chiral compounds and their use in asymmetric catalysis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
-
1991
- 1991-04-29 AU AU76182/91A patent/AU634380B2/en not_active Ceased
- 1991-05-14 MX MX2577791A patent/MX25777A/es unknown
- 1991-05-14 AR AR91319694A patent/AR247888A1/es active
- 1991-05-15 NZ NZ238151A patent/NZ238151A/en unknown
- 1991-05-15 NO NO911892A patent/NO177710C/no not_active IP Right Cessation
- 1991-05-15 CZ CS911429A patent/CZ280922B6/cs not_active IP Right Cessation
- 1991-05-15 FI FI912363A patent/FI96689C/fi active
- 1991-05-15 NZ NZ260210A patent/NZ260210A/en unknown
- 1991-05-16 PL PL29027391A patent/PL290273A1/xx unknown
- 1991-05-16 IE IE167891A patent/IE76318B1/en not_active IP Right Cessation
- 1991-05-16 AT AT91107942T patent/ATE141273T1/de not_active IP Right Cessation
- 1991-05-16 ZA ZA913711A patent/ZA913711B/xx unknown
- 1991-05-16 JP JP3139418A patent/JPH0826024B2/ja not_active Expired - Lifetime
- 1991-05-16 KR KR1019910007922A patent/KR100215615B1/ko not_active Expired - Fee Related
- 1991-05-16 DK DK91107942.4T patent/DK0457318T3/da active
- 1991-05-16 PT PT97688A patent/PT97688B/pt not_active IP Right Cessation
- 1991-05-16 ES ES91107942T patent/ES2094768T3/es not_active Expired - Lifetime
- 1991-05-16 DE DE69121299T patent/DE69121299T2/de not_active Expired - Fee Related
- 1991-05-16 MX MX2581691A patent/MX25816A/es unknown
- 1991-05-16 CA CA002042737A patent/CA2042737A1/en not_active Abandoned
- 1991-05-16 EP EP91107942A patent/EP0457318B1/en not_active Expired - Lifetime
- 1991-05-16 IL IL9816291A patent/IL98162A/en unknown
- 1991-05-17 HU HU911658A patent/HU210179B/hu not_active IP Right Cessation
-
1996
- 1996-09-13 GR GR960402402T patent/GR3021043T3/el unknown
-
1999
- 1999-02-03 KR KR1019990003497A patent/KR100227715B1/ko not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20000515 |