AR247888A1 - Un procedimiento para la preparacion de acidos oxopirrolo/2, 3-b/-acetico, sus esteres, amidas y analogos afines. - Google Patents

Un procedimiento para la preparacion de acidos oxopirrolo/2, 3-b/-acetico, sus esteres, amidas y analogos afines.

Info

Publication number
AR247888A1
AR247888A1 AR91319694A AR31969491A AR247888A1 AR 247888 A1 AR247888 A1 AR 247888A1 AR 91319694 A AR91319694 A AR 91319694A AR 31969491 A AR31969491 A AR 31969491A AR 247888 A1 AR247888 A1 AR 247888A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
oxopyrrolo
medicaments
amides
Prior art date
Application number
AR91319694A
Other languages
English (en)
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of AR247888A1 publication Critical patent/AR247888A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA I DONDE X ES -NH, -O , N-ALQUILO, O N-ARIL-ALQUILO; R1 ES ALQUILO, CICLOALQUILO, ARILO, ARIL- ALQUILO, ALQUILENO, HALO-ALQUILO, TIENILO, FURANILO, PIRROLILO Y PIRIDINILO; HETEROARIL-ALQUILO SIENDO EL HETEROCICLO PIPERIDINILO, PIPERAZINILO O PIRROLIDINILO; O HETEROCICLICO-ALQUILO; R2 ES H O ALQUILO; R3 ES ALQUILO O ARIL-ALQUILO; R4 ESH, ALQUILO, ALQUENILO, ALQUINILO, ARIL- ALQUILO, FORMILO, ALQUILO-CARBONILO, ARIL-ALQUILO-CARBONILO O ALCOXI- CARBONILO; E Y ES H, HALOGENO, ALQUILO O ALCOXI QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE LA FORMULA IV CON UN OXALATO DE DIALQUILO DE LA FORMULA VII DONDE R ES ALQUILO, ARILO O ARIL-ALQUILO, EN PRESENCIA DE N, N, N', -N'-TETRAMETILETILENDIAMINA Y SEC-BUTIL-LITIO, PARA OBTENER UN COMPUESTO DE LA FORMULA I EN DONDE R1 TIENE EL SIGNIFICADO DE R ANTERIOR.
AR91319694A 1990-05-17 1991-05-14 Un procedimiento para la preparacion de acidos oxopirrolo/2, 3-b/-acetico, sus esteres, amidas y analogos afines. AR247888A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52462790A 1990-05-17 1990-05-17

Publications (1)

Publication Number Publication Date
AR247888A1 true AR247888A1 (es) 1995-04-28

Family

ID=24090019

Family Applications (1)

Application Number Title Priority Date Filing Date
AR91319694A AR247888A1 (es) 1990-05-17 1991-05-14 Un procedimiento para la preparacion de acidos oxopirrolo/2, 3-b/-acetico, sus esteres, amidas y analogos afines.

Country Status (22)

Country Link
EP (1) EP0457318B1 (es)
JP (1) JPH0826024B2 (es)
KR (2) KR100215615B1 (es)
AR (1) AR247888A1 (es)
AT (1) ATE141273T1 (es)
AU (1) AU634380B2 (es)
CA (1) CA2042737A1 (es)
CZ (1) CZ280922B6 (es)
DE (1) DE69121299T2 (es)
DK (1) DK0457318T3 (es)
ES (1) ES2094768T3 (es)
FI (1) FI96689C (es)
GR (1) GR3021043T3 (es)
HU (1) HU210179B (es)
IE (1) IE76318B1 (es)
IL (1) IL98162A (es)
MX (2) MX25777A (es)
NO (1) NO177710C (es)
NZ (2) NZ238151A (es)
PL (1) PL290273A1 (es)
PT (1) PT97688B (es)
ZA (1) ZA913711B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983616A (en) * 1990-02-01 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
AU634654B2 (en) * 1990-05-11 1993-02-25 Hoechst-Roussel Pharmaceuticals Incorporated Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments
MC2287A1 (fr) * 1990-06-27 1993-07-14 Hoechst Roussel Pharma Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole
EP1283199A4 (en) 2000-05-16 2003-12-17 Takeda Chemical Industries Ltd MELANIN CONCENTRATION HORMONE ANTAGONIST
WO2010027334A1 (en) 2008-09-03 2010-03-11 Nanyang Technological University Novel tricyclic chiral compounds and their use in asymmetric catalysis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4971992A (en) * 1989-03-27 1990-11-20 Hoechst-Roussel Pharmaceuticals Inc. Carbonate derivatives of eseroline

Also Published As

Publication number Publication date
IL98162A (en) 1994-12-29
ZA913711B (en) 1992-01-29
ATE141273T1 (de) 1996-08-15
IE76318B1 (en) 1997-10-22
FI912363A0 (fi) 1991-05-15
GR3021043T3 (en) 1996-12-31
IL98162A0 (en) 1992-06-21
KR100227715B1 (ko) 2000-03-15
JPH04226989A (ja) 1992-08-17
FI96689C (fi) 1996-08-12
NO177710C (no) 1995-11-08
ES2094768T3 (es) 1997-02-01
AU7618291A (en) 1991-11-21
AU634380B2 (en) 1993-02-18
CA2042737A1 (en) 1991-11-18
EP0457318A1 (en) 1991-11-21
DK0457318T3 (da) 1996-12-09
JPH0826024B2 (ja) 1996-03-13
EP0457318B1 (en) 1996-08-14
DE69121299D1 (de) 1996-09-19
CS142991A3 (en) 1992-01-15
NO911892L (no) 1991-11-18
FI912363A (fi) 1991-11-18
HU210179B (en) 1995-02-28
NO911892D0 (no) 1991-05-15
DE69121299T2 (de) 1997-02-06
PT97688B (pt) 1998-08-31
HUT61310A (en) 1992-12-28
FI96689B (fi) 1996-04-30
PL290273A1 (en) 1992-07-27
NO177710B (no) 1995-07-31
KR100215615B1 (ko) 1999-08-16
PT97688A (pt) 1992-02-28
IE911678A1 (en) 1991-11-20
MX25777A (es) 1993-10-01
NZ238151A (es) 1996-02-27
NZ260210A (en) 1996-02-27
CZ280922B6 (cs) 1996-05-15
HU911658D0 (en) 1991-11-28
KR910020014A (ko) 1991-12-19
MX25816A (es) 1993-11-01

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