MC2287A1 - Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole - Google Patents

Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole

Info

Publication number
MC2287A1
MC2287A1 MC90@@D MC2287D MC2287A1 MC 2287 A1 MC2287 A1 MC 2287A1 MC 2287 D MC2287 D MC 2287D MC 2287 A1 MC2287 A1 MC 2287A1
Authority
MC
Monaco
Prior art keywords
trimethylpyrrolo
hexahydro
indole
tetrahydroisoquinoleinylcarbamates
loweralkyl
Prior art date
Application number
MC90@@D
Other languages
English (en)
Inventor
Russel Hamer
Grover Helsley
Edward Glamzowski
Yulin Chiang
Brian Freed
Barbara Kurys
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of MC2287A1 publication Critical patent/MC2287A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MC90@@D 1990-06-27 1990-06-27 Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole MC2287A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/003552 WO1992000072A1 (fr) 1990-06-27 1990-06-27 Tetrahydroisoquinolinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimenthylpyrrolo[2,3-b] indole

Publications (1)

Publication Number Publication Date
MC2287A1 true MC2287A1 (fr) 1993-07-14

Family

ID=22220922

Family Applications (1)

Application Number Title Priority Date Filing Date
MC90@@D MC2287A1 (fr) 1990-06-27 1990-06-27 Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole

Country Status (18)

Country Link
EP (1) EP0538248B1 (fr)
KR (1) KR0172971B1 (fr)
AT (1) ATE163183T1 (fr)
AU (1) AU649953B2 (fr)
BG (1) BG61188B1 (fr)
DE (1) DE69032046T2 (fr)
DK (1) DK0538248T3 (fr)
ES (1) ES2113859T3 (fr)
FI (1) FI97229C (fr)
GE (1) GEP19991747B (fr)
LT (1) LT3598B (fr)
LV (1) LV10189B (fr)
MC (1) MC2287A1 (fr)
NO (1) NO179910C (fr)
RO (1) RO110501B1 (fr)
RU (1) RU2124516C1 (fr)
SG (1) SG70968A1 (fr)
WO (1) WO1992000072A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1271679B (it) * 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) * 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers
EP1149079B1 (fr) * 1999-02-04 2004-04-21 SK Corporation Derives de tetrahydro isoquino linealcanol et compositions pharmaceutiques contenants ces derives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
AU634380B2 (en) * 1990-05-17 1993-02-18 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
LTIP923A (en) 1995-03-27
FI97229B (fi) 1996-07-31
LV10189A (lv) 1994-10-20
NO925008D0 (no) 1992-12-23
NO179910C (no) 1997-01-08
DK0538248T3 (da) 1998-09-23
SG70968A1 (en) 2000-03-21
RU2124516C1 (ru) 1999-01-10
DE69032046D1 (de) 1998-03-19
WO1992000072A1 (fr) 1992-01-09
AU5931390A (en) 1992-01-23
BG61188B1 (bg) 1997-02-28
RO110501B1 (ro) 1996-01-30
AU649953B2 (en) 1994-06-09
ES2113859T3 (es) 1998-05-16
FI925872A (fi) 1992-12-23
LT3598B (en) 1995-12-27
ATE163183T1 (de) 1998-02-15
BG97231A (bg) 1993-12-24
FI97229C (fi) 1996-11-11
NO925008L (no) 1992-12-23
EP0538248B1 (fr) 1998-02-11
EP0538248A1 (fr) 1993-04-28
EP0538248A4 (fr) 1994-08-03
NO179910B (no) 1996-09-30
FI925872A0 (fi) 1992-12-23
GEP19991747B (en) 1999-09-10
KR0172971B1 (ko) 1999-02-01
LV10189B (en) 1995-08-20
DE69032046T2 (de) 1998-08-27

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