ATE163183T1 - Tetrahydroisochinolinylcarbamate von 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b> indol - Google Patents

Tetrahydroisochinolinylcarbamate von 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b> indol

Info

Publication number
ATE163183T1
ATE163183T1 AT90910230T AT90910230T ATE163183T1 AT E163183 T1 ATE163183 T1 AT E163183T1 AT 90910230 T AT90910230 T AT 90910230T AT 90910230 T AT90910230 T AT 90910230T AT E163183 T1 ATE163183 T1 AT E163183T1
Authority
AT
Austria
Prior art keywords
trimethylpyrrolo
hexahydro
indole
tetrahydroisochinolinylcarbamates
loweralkyl
Prior art date
Application number
AT90910230T
Other languages
English (en)
Inventor
Russell Richard Lee Hamer
Grover Cleveland Helsley
Edward Joseph Glamkowski
Yulin Chiang
Brian Scott Freed
Barbara Elaine Kurys
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ATE163183T1 publication Critical patent/ATE163183T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT90910230T 1990-06-27 1990-06-27 Tetrahydroisochinolinylcarbamate von 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b> indol ATE163183T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/003552 WO1992000072A1 (en) 1990-06-27 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole

Publications (1)

Publication Number Publication Date
ATE163183T1 true ATE163183T1 (de) 1998-02-15

Family

ID=22220922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90910230T ATE163183T1 (de) 1990-06-27 1990-06-27 Tetrahydroisochinolinylcarbamate von 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b> indol

Country Status (18)

Country Link
EP (1) EP0538248B1 (de)
KR (1) KR0172971B1 (de)
AT (1) ATE163183T1 (de)
AU (1) AU649953B2 (de)
BG (1) BG61188B1 (de)
DE (1) DE69032046T2 (de)
DK (1) DK0538248T3 (de)
ES (1) ES2113859T3 (de)
FI (1) FI97229C (de)
GE (1) GEP19991747B (de)
LT (1) LT3598B (de)
LV (1) LV10189B (de)
MC (1) MC2287A1 (de)
NO (1) NO179910C (de)
RO (1) RO110501B1 (de)
RU (1) RU2124516C1 (de)
SG (1) SG70968A1 (de)
WO (1) WO1992000072A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1271679B (it) * 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) * 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers
PT1149079E (pt) * 1999-02-04 2004-08-31 Sk Corp Derivados de tetra-hidroisoquinolina-alcanol e composicoes farmaceuticas que os contem

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
AU634380B2 (en) * 1990-05-17 1993-02-18 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
FI97229C (fi) 1996-11-11
WO1992000072A1 (en) 1992-01-09
FI925872A0 (fi) 1992-12-23
MC2287A1 (fr) 1993-07-14
AU5931390A (en) 1992-01-23
LT3598B (en) 1995-12-27
NO925008L (no) 1992-12-23
RO110501B1 (ro) 1996-01-30
NO179910B (no) 1996-09-30
GEP19991747B (en) 1999-09-10
DE69032046T2 (de) 1998-08-27
NO179910C (no) 1997-01-08
FI97229B (fi) 1996-07-31
RU2124516C1 (ru) 1999-01-10
LV10189B (en) 1995-08-20
SG70968A1 (en) 2000-03-21
ES2113859T3 (es) 1998-05-16
LTIP923A (en) 1995-03-27
EP0538248B1 (de) 1998-02-11
LV10189A (lv) 1994-10-20
BG97231A (bg) 1993-12-24
DK0538248T3 (da) 1998-09-23
NO925008D0 (no) 1992-12-23
DE69032046D1 (de) 1998-03-19
AU649953B2 (en) 1994-06-09
EP0538248A1 (de) 1993-04-28
FI925872A (fi) 1992-12-23
BG61188B1 (bg) 1997-02-28
KR0172971B1 (ko) 1999-02-01
EP0538248A4 (de) 1994-08-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee