CA2085216A1 - Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b| indole - Google Patents

Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b| indole

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Publication number
CA2085216A1
CA2085216A1 CA2085216A CA2085216A CA2085216A1 CA 2085216 A1 CA2085216 A1 CA 2085216A1 CA 2085216 A CA2085216 A CA 2085216A CA 2085216 A CA2085216 A CA 2085216A CA 2085216 A1 CA2085216 A1 CA 2085216A1
Authority
CA
Canada
Prior art keywords
tetrahydroisoquinolinylcarbamates
trimethylpyrrolo
hexahydro
indole
loweralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2085216A
Other languages
French (fr)
Other versions
CA2085216C (en
Inventor
Russell Richard Lee Hamer
Grover Cleveland Helsley
Yulin Chiang
Edward Joseph Glamkowski
Brian Scott Freed
Barbara Elaine Kurys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Russell Richard Lee Hamer
Grover Cleveland Helsley
Yulin Chiang
Edward Joseph Glamkowski
Brian Scott Freed
Barbara Elaine Kurys
Hoechst-Roussel Pharmaceuticals Inc.
Aventis Pharmaceuticals Inc.
Hoechst Marion Roussel, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/049,894 external-priority patent/US4791107A/en
Application filed by Russell Richard Lee Hamer, Grover Cleveland Helsley, Yulin Chiang, Edward Joseph Glamkowski, Brian Scott Freed, Barbara Elaine Kurys, Hoechst-Roussel Pharmaceuticals Inc., Aventis Pharmaceuticals Inc., Hoechst Marion Roussel, Inc. filed Critical Russell Richard Lee Hamer
Priority to CA002085216A priority Critical patent/CA2085216C/en
Priority claimed from PCT/US1990/003552 external-priority patent/WO1992000072A1/en
Publication of CA2085216A1 publication Critical patent/CA2085216A1/en
Application granted granted Critical
Publication of CA2085216C publication Critical patent/CA2085216C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

There are disclosed tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole of formula (I), where R is hydrogen or loweralkyl; and X is hydrogen, loweralkyl, halogen, loweralkoxy or hydroxy, which compounds being useful for alleviating memory dysfunctions characterized by a cholinergic deficit.
CA002085216A 1987-05-15 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b| indole Expired - Fee Related CA2085216C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002085216A CA2085216C (en) 1987-05-15 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b| indole

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/049,894 US4791107A (en) 1986-07-16 1987-05-15 Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
CA002085216A CA2085216C (en) 1987-05-15 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b| indole
PCT/US1990/003552 WO1992000072A1 (en) 1990-06-27 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole

Publications (2)

Publication Number Publication Date
CA2085216A1 true CA2085216A1 (en) 1991-12-28
CA2085216C CA2085216C (en) 2000-12-05

Family

ID=34841305

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002085216A Expired - Fee Related CA2085216C (en) 1987-05-15 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b| indole

Country Status (1)

Country Link
CA (1) CA2085216C (en)

Also Published As

Publication number Publication date
CA2085216C (en) 2000-12-05

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