PT97688B - Processo para a preparacao de amidas, esteres, acidos alfa-oxo-pirrolo{2,3-b}indol-acetico e analogos relacionados e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de amidas, esteres, acidos alfa-oxo-pirrolo{2,3-b}indol-acetico e analogos relacionados e de composicoes farmaceuticas que os contem Download PDF

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Publication number
PT97688B
PT97688B PT97688A PT9768891A PT97688B PT 97688 B PT97688 B PT 97688B PT 97688 A PT97688 A PT 97688A PT 9768891 A PT9768891 A PT 9768891A PT 97688 B PT97688 B PT 97688B
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formula
compound
preparation
pharmaceutical composition
quot
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PT97688A
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English (en)
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PT97688A (pt
Inventor
Denise M Flanagen
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Hoechst Roussel Pharma
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Publication of PT97688A publication Critical patent/PT97688A/pt
Publication of PT97688B publication Critical patent/PT97688B/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Description

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Claims (1)

  1. om ψ írf= · Μ. 0xai-gçcI He $ιν&ιφ&&φ as «wjs%iya ¥*x
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    -!»!
    /iB.ipe u&t M4imgtó4* aifili® • eEHSfflPaSFp-mFmm .mm ST^M&WMQE&JtO xni€írjuOF fla pF©»eM<|a IH® I® . e tl^^^ãfl^fcil^fellesô iteáaa h Hj, ll®ÍÍt -€®§Ι®®§ pIlFâ' §Sfl: miám w ftmposfà 4a fmmúm M§m tp@. IJ *®»t l-^i«l& m: iiifs^isr e 31$ M M4ftgli#iif M'fUriUb4ftQàÍl9- ÉrttoriN -<BPè;': '· · · -. .· , = · : ; . «sf; --:.--- " ; á?<aôêâs® ie m&Pã& côBi çt j?ê4wÉfi44<$a-êitô) f p ^aefeei^zftÉ^ psiF l|g ^ |$^ @ 1|$- sere® -# 1 ««r &&» ^ 4& mõFââ mm m ʧ/m» pu* .1. ecé» **®· -® 'B| mr &ΛφΑ%Μ m -'»&βφΧφΛίι6' Jto»' fe^* *ev: S* <=-> ' .dSbaa,. ‘#6ι*|ί.<ίίίβ#Μΐϊ»·ί- ·^ <&.ϋΐί. · «s . pÉp- &44a S^t ^ @ ^ - .^ep sel4®o* .-.ÉNBEMSé» _ÉÍ- S§SPɧ -@e:âff .fH »: racterizado por se obter o n-butil éster do ácido 1,2,3,3a,8,8a -hexa-hidro-o(-oxo,1,3a,8-tri-metil~5-pirrolo[2,3-b]Índol-acétÍ-co. Processo de acordo com a reivindicação 1, ea-racterizado por se obter o n-pentil ester do ácido 1,2,3,3a,8, 8a-hexa-hidro-fl(-oxo-1,3a.8-tr£metil-5-pirrolo[2,3-b3indol-ace-tico. - 73 - Processo de acordo com a reivindicação 1, carácter izado por se obter o fenilmetil ester do ácido 1,2,3, 3a, 8, 8a-hexa-hidr o-«(-oxo- 1,3a, 8-1 r imet il-5~pirrolo[2,3-b 1-indol-acético. - 83 - Processo de acordo com a reivindicação 1, ca-racterizado por se obter o fenil-etil ester do ácido 1,2,3,3a, 8,8a-hexa-hidro-c(-oxo- 1,3a, 8-trimetil-5-pirrolo 12,3-b 3-indol-acético. - 9» - Processo para a preparação de uma composição farmacêutico caracterizado por se incorporar como ingrediente activo um composto de fórmula I quando preparado de acordo com a reivindicação 1.  requerente reivindica a prioridade do pedido de patente norte-americano apresentado em 17 de Maio de 1990, sob o numero de série 52*1,627* - 34 - Lisboa, 16 de Maio de 1991
    35 - RESUMO "PROCESSO PARA A PREPARAÇgQ DE ÃMIDAS, ESTERES» ÁCIDOS q-OXO--PIRROLOE 2, 3-b 3ISDOL-ACÉTICO K ANÁLOGOS RELACIONADOS E BE COM-POSIÇÕES FARMACÊUTICAS QOE OS CONTfiM» A invenção refere-se a um processo para a preparação de um composto da fórmula I
    R3 Ri| (I) dos seus sais de adição de ácido farmaceutieamente aceitáveis, e quando aplicável, dos seus isómeros geométricos e opticos e misturas racómicas, a) que compreende nomeadamente fazer-se reagir um composto da fórmula IV
    R3 R4 (IV) com um oxalato de di-alquilo da fórmula VII O
    (VII) na presença de Ν,Ν,Ν’,Ν’-tetra-metil-etileno-diamina e sec-bu-til-litio, para se obter um composto da fórmula I*
PT97688A 1990-05-17 1991-05-16 Processo para a preparacao de amidas, esteres, acidos alfa-oxo-pirrolo{2,3-b}indol-acetico e analogos relacionados e de composicoes farmaceuticas que os contem PT97688B (pt)

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US4983616A (en) * 1990-02-01 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
AU634654B2 (en) * 1990-05-11 1993-02-25 Hoechst-Roussel Pharmaceuticals Incorporated Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments
MC2287A1 (fr) * 1990-06-27 1993-07-14 Hoechst Roussel Pharma Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole
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US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
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ATE141273T1 (de) 1996-08-15
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FI912363A0 (fi) 1991-05-15
GR3021043T3 (en) 1996-12-31
IL98162A0 (en) 1992-06-21
KR100227715B1 (ko) 2000-03-15
JPH04226989A (ja) 1992-08-17
FI96689C (fi) 1996-08-12
NO177710C (no) 1995-11-08
ES2094768T3 (es) 1997-02-01
AU7618291A (en) 1991-11-21
AU634380B2 (en) 1993-02-18
CA2042737A1 (en) 1991-11-18
EP0457318A1 (en) 1991-11-21
DK0457318T3 (da) 1996-12-09
JPH0826024B2 (ja) 1996-03-13
EP0457318B1 (en) 1996-08-14
AR247888A1 (es) 1995-04-28
DE69121299D1 (de) 1996-09-19
CS142991A3 (en) 1992-01-15
NO911892L (no) 1991-11-18
FI912363A (fi) 1991-11-18
HU210179B (en) 1995-02-28
NO911892D0 (no) 1991-05-15
DE69121299T2 (de) 1997-02-06
HUT61310A (en) 1992-12-28
FI96689B (fi) 1996-04-30
PL290273A1 (en) 1992-07-27
NO177710B (no) 1995-07-31
KR100215615B1 (ko) 1999-08-16
PT97688A (pt) 1992-02-28
IE911678A1 (en) 1991-11-20
MX25777A (es) 1993-10-01
NZ238151A (pt) 1996-02-27
NZ260210A (en) 1996-02-27
CZ280922B6 (cs) 1996-05-15
HU911658D0 (en) 1991-11-28
KR910020014A (ko) 1991-12-19
MX25816A (es) 1993-11-01

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