CY1122128T1 - Θεραπεια ενζυμικης αντικαταστασης με κλιμακωση δοσης για αντιμετωπιση ανεπαρκειας σε οξινη σφιγγομυελιναση - Google Patents

Θεραπεια ενζυμικης αντικαταστασης με κλιμακωση δοσης για αντιμετωπιση ανεπαρκειας σε οξινη σφιγγομυελιναση

Info

Publication number
CY1122128T1
CY1122128T1 CY20191100808T CY191100808T CY1122128T1 CY 1122128 T1 CY1122128 T1 CY 1122128T1 CY 20191100808 T CY20191100808 T CY 20191100808T CY 191100808 T CY191100808 T CY 191100808T CY 1122128 T1 CY1122128 T1 CY 1122128T1
Authority
CY
Cyprus
Prior art keywords
treatment
deficiency
replacement therapy
acid
enzyme replacement
Prior art date
Application number
CY20191100808T
Other languages
Greek (el)
English (en)
Inventor
Edward H. Schuchman
Robert J. Desnick
Gerald F. Cox
Laura P. Andrews
James M. Murray
Original Assignee
Icahn School Of Medicine At Mount Sinai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43625265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1122128(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icahn School Of Medicine At Mount Sinai filed Critical Icahn School Of Medicine At Mount Sinai
Publication of CY1122128T1 publication Critical patent/CY1122128T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Dermatology (AREA)
CY20191100808T 2009-08-28 2019-07-29 Θεραπεια ενζυμικης αντικαταστασης με κλιμακωση δοσης για αντιμετωπιση ανεπαρκειας σε οξινη σφιγγομυελιναση CY1122128T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23811309P 2009-08-28 2009-08-28
PCT/US2010/047057 WO2011025996A2 (en) 2009-08-28 2010-08-28 Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency

Publications (1)

Publication Number Publication Date
CY1122128T1 true CY1122128T1 (el) 2020-11-25

Family

ID=43625265

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100808T CY1122128T1 (el) 2009-08-28 2019-07-29 Θεραπεια ενζυμικης αντικαταστασης με κλιμακωση δοσης για αντιμετωπιση ανεπαρκειας σε οξινη σφιγγομυελιναση

Country Status (30)

Country Link
US (9) US8349319B2 (enExample)
EP (4) EP2470199B1 (enExample)
JP (8) JP5955219B2 (enExample)
KR (6) KR102094253B1 (enExample)
CN (3) CN105999238A (enExample)
AU (6) AU2010286550B2 (enExample)
BR (1) BR112012004377A2 (enExample)
CA (1) CA2773133A1 (enExample)
CL (1) CL2012000495A1 (enExample)
CY (1) CY1122128T1 (enExample)
DK (3) DK3482767T3 (enExample)
ES (3) ES3052684T3 (enExample)
FI (2) FI3998078T3 (enExample)
FR (1) FR22C1062I2 (enExample)
HR (3) HRP20251310T1 (enExample)
HU (3) HUE057440T2 (enExample)
IL (4) IL314807A (enExample)
LT (4) LT3998078T (enExample)
LU (1) LUC00288I2 (enExample)
MX (2) MX356873B (enExample)
NL (1) NL301211I2 (enExample)
NO (1) NO2022054I1 (enExample)
PL (3) PL2470199T3 (enExample)
PT (3) PT3482767T (enExample)
RU (2) RU2731616C2 (enExample)
SI (3) SI2470199T1 (enExample)
SM (1) SMT202500432T1 (enExample)
TR (1) TR201911293T4 (enExample)
WO (1) WO2011025996A2 (enExample)
ZA (2) ZA201201435B (enExample)

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CN106047835A (zh) 2016-10-26
NL301211I2 (nl) 2023-02-02
KR20210107153A (ko) 2021-08-31
US20180055916A1 (en) 2018-03-01
ES3052684T3 (en) 2026-01-13
JP7605949B2 (ja) 2024-12-24
PL2470199T3 (pl) 2019-11-29
HUS2200050I1 (hu) 2022-12-28
ZA201201435B (en) 2020-05-27
SI2470199T1 (sl) 2019-11-29
CA2773133A1 (en) 2011-03-03
RU2020128994A (ru) 2022-03-02
TR201911293T4 (tr) 2019-08-21
SI3998078T1 (sl) 2026-02-27
EP4681775A2 (en) 2026-01-21
US20110052559A1 (en) 2011-03-03
IL266915B1 (en) 2023-03-01
RU2569744C2 (ru) 2015-11-27
AU2016216625B2 (en) 2018-07-05
LT2470199T (lt) 2019-10-10
JP7395693B2 (ja) 2023-12-11
US20130078231A1 (en) 2013-03-28
CN102596232A (zh) 2012-07-18
ES2902229T3 (es) 2022-03-25
LUC00288I2 (enExample) 2025-05-12
DK3998078T3 (da) 2025-11-17
IL300625B2 (en) 2025-01-01
IL300625B1 (en) 2024-09-01
JP7167281B2 (ja) 2022-11-08
AU2020256322A1 (en) 2020-11-12
US20190151419A1 (en) 2019-05-23
JP6952810B2 (ja) 2021-10-20
AU2025205539A1 (en) 2025-08-07
AU2020256322B2 (en) 2024-02-29
RU2731616C2 (ru) 2020-09-07
LTC3482767I2 (enExample) 2024-03-25
PL3998078T3 (pl) 2026-02-16
JP2024026214A (ja) 2024-02-28
DK3482767T3 (da) 2021-12-20
FI3998078T3 (fi) 2025-12-04
US8658162B2 (en) 2014-02-25
CL2012000495A1 (es) 2014-02-07
KR102893390B1 (ko) 2025-11-28
US8349319B2 (en) 2013-01-08
EP3482767B1 (en) 2021-10-06
IL218324A0 (en) 2012-04-30
BR112012004377A2 (pt) 2017-12-12
SMT202500432T1 (it) 2026-01-12
JP2020090513A (ja) 2020-06-11
HUE046598T2 (hu) 2020-03-30
FR22C1062I1 (fr) 2023-02-03
PT3482767T (pt) 2021-12-29
KR20220104271A (ko) 2022-07-26
JP5955219B2 (ja) 2016-07-20
RU2015145255A (ru) 2019-01-11
AU2010286550A1 (en) 2012-03-15
HRP20211992T1 (hr) 2022-04-01
WO2011025996A3 (en) 2012-03-15
AU2024201085B2 (en) 2025-04-24
NO2022054I1 (no) 2022-12-01
KR20250171458A (ko) 2025-12-08
JP2013502933A (ja) 2013-01-31
US10188705B2 (en) 2019-01-29
AU2018204156B2 (en) 2020-07-16
CN105999238A (zh) 2016-10-12
EP3482767A1 (en) 2019-05-15
FIC20220051I1 (fi) 2022-12-20
KR102608551B1 (ko) 2023-12-04
ZA201601362B (en) 2017-05-31
RU2012111823A (ru) 2013-10-10
PT2470199T (pt) 2019-08-07
AU2010286550B2 (en) 2016-05-19
MX356873B (es) 2018-06-18
NL301211I1 (nl) 2022-12-28
KR102094253B1 (ko) 2020-03-31
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KR20200034828A (ko) 2020-03-31
HRP20251310T1 (hr) 2026-01-02
US9114139B2 (en) 2015-08-25
SI3482767T1 (sl) 2022-03-31
AU2018204156A1 (en) 2018-06-28
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PL3482767T3 (pl) 2022-02-14
RU2015145255A3 (enExample) 2019-08-12
US20210077593A1 (en) 2021-03-18
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EP3998078B1 (en) 2025-10-01
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EP2470199A4 (en) 2013-03-27
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US20140335070A1 (en) 2014-11-13
LT3482767T (lt) 2022-01-10
PT3998078T (pt) 2025-11-07
IL218324B (en) 2019-05-30
US20160120957A1 (en) 2016-05-05
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JP2022003065A (ja) 2022-01-11
WO2011025996A9 (en) 2011-08-25
FR22C1062I2 (fr) 2023-12-29
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US9655954B2 (en) 2017-05-23
US8709408B2 (en) 2014-04-29
IL314807A (en) 2024-10-01
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US20130078230A1 (en) 2013-03-28
JP2016153408A (ja) 2016-08-25
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LT3998078T (lt) 2025-12-29
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