CY1116490T1 - Φαρμακευτικες συνθεσεις κλεβιδιπινης και μεθοδοι για την παραγωγη συγκεντρωσεων χαμηλων προσμιξεων των ιδιων - Google Patents

Φαρμακευτικες συνθεσεις κλεβιδιπινης και μεθοδοι για την παραγωγη συγκεντρωσεων χαμηλων προσμιξεων των ιδιων

Info

Publication number
CY1116490T1
CY1116490T1 CY20141100388T CY141100388T CY1116490T1 CY 1116490 T1 CY1116490 T1 CY 1116490T1 CY 20141100388 T CY20141100388 T CY 20141100388T CY 141100388 T CY141100388 T CY 141100388T CY 1116490 T1 CY1116490 T1 CY 1116490T1
Authority
CY
Cyprus
Prior art keywords
klevidipin
methods
pharmaceutical compositions
low primary
concentrating low
Prior art date
Application number
CY20141100388T
Other languages
English (en)
Inventor
Rajeshwar Motheram
Gopal Krishna
Min Ding
Keith Flood
Kornepati Ramakrishna
Original Assignee
The Medicines Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41610719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116490(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Medicines Company filed Critical The Medicines Company
Publication of CY1116490T1 publication Critical patent/CY1116490T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Περιγράφεται σύνθεση που έχει κλεβιδιπίνη ως δραστικό συστατικό μείγματος. Η σύνθεση συμπεριλαμβάνει κλεβιδίπίνη ως δραστικό συστατικό μείγματος και ποσότητα της πρόσμιξης Η168/79 που δεν είναι μεγαλύτερη από περίπου 1.5%, όπου ο λόγος μεταξύ κλεβιδιπίνης και Η168/79 είναι ισοδύναμος με ή άνωθεν του 60 προς 1.
CY20141100388T 2008-08-01 2014-05-30 Φαρμακευτικες συνθεσεις κλεβιδιπινης και μεθοδοι για την παραγωγη συγκεντρωσεων χαμηλων προσμιξεων των ιδιων CY1116490T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8559708P 2008-08-01 2008-08-01
US9377208P 2008-09-03 2008-09-03
EP09803550.4A EP2320740B1 (en) 2008-08-01 2009-07-29 Pharmaceutical compositions of clevidipine and methods for producing low impurity concentrations of the same

Publications (1)

Publication Number Publication Date
CY1116490T1 true CY1116490T1 (el) 2017-03-15

Family

ID=41610719

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100388T CY1116490T1 (el) 2008-08-01 2014-05-30 Φαρμακευτικες συνθεσεις κλεβιδιπινης και μεθοδοι για την παραγωγη συγκεντρωσεων χαμηλων προσμιξεων των ιδιων

Country Status (20)

Country Link
US (5) US20100113534A1 (el)
EP (2) EP2320740B1 (el)
JP (1) JP5674660B2 (el)
KR (1) KR101772602B1 (el)
CN (1) CN102170786B (el)
AU (1) AU2009276560B2 (el)
BR (1) BRPI0916936B8 (el)
CA (2) CA2732760A1 (el)
CY (1) CY1116490T1 (el)
DK (1) DK2320740T3 (el)
EA (1) EA021336B1 (el)
ES (1) ES2468837T3 (el)
HR (1) HRP20140434T1 (el)
MX (1) MX2011001240A (el)
NZ (1) NZ591205A (el)
PL (1) PL2320740T3 (el)
PT (1) PT2320740E (el)
SI (1) SI2320740T1 (el)
SM (1) SMT201400081B (el)
WO (1) WO2010014727A1 (el)

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BRPI0916936B8 (pt) 2008-08-01 2021-05-25 Chiesi Farm Spa composições farmacêuticas, uso de clevidipina e método de reduzir impurezas.
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
MX2013004151A (es) * 2010-10-12 2013-05-20 Medicines Co Formulaciones de emulsion de clevidipina que contienen agentes antimicrobianos.
CN103134891A (zh) * 2011-11-30 2013-06-05 天津金耀集团有限公司 一种丁酸氯维地平含量和有关物质的测定方法
CN110840890A (zh) 2012-10-26 2020-02-28 凯西制药公司 用于在心力衰竭中控制血压和减轻呼吸困难的方法
CN103417539B (zh) * 2013-08-22 2015-11-25 北京蓝丹医药科技有限公司 一种丁酸氯维地平药物组合物
CN104974042A (zh) * 2014-04-09 2015-10-14 上海信谊金朱药业有限公司 化合物的制备方法
CN104974043A (zh) * 2014-04-09 2015-10-14 上海信谊金朱药业有限公司 丁酸氯维地平的杂质化合物的制备方法
CN106456617A (zh) 2014-05-19 2017-02-22 医药公司 氯维地平纳米颗粒及其药物组合物
CN104458937B (zh) * 2014-11-20 2017-02-22 北京京科泰来科技有限公司 一种丁酸氯维地平脂肪乳有关物质检测方法
CN104597192B (zh) * 2014-12-31 2016-08-24 武汉科福新药有限责任公司 一种丁酸氯维地平及其制剂中有关物质的检测方法
CN105853353A (zh) * 2015-01-20 2016-08-17 江苏正大丰海制药有限公司 一种氯维地平脂肪乳注射液的制备方法
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CN109956943B (zh) * 2019-04-18 2021-07-20 合肥合源药业有限公司 一种二氢吡啶类药物中脱羧缩合杂质及其制备、控制方法

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Also Published As

Publication number Publication date
CN102170786A (zh) 2011-08-31
CN102170786B (zh) 2015-05-27
NZ591205A (en) 2012-11-30
BRPI0916936A2 (pt) 2017-05-23
EP2320740B1 (en) 2014-03-26
PL2320740T3 (pl) 2014-09-30
EP2320740A4 (en) 2011-11-30
US20220000849A1 (en) 2022-01-06
SI2320740T1 (sl) 2014-08-29
KR101772602B1 (ko) 2017-08-29
PT2320740E (pt) 2014-06-12
US20190091212A1 (en) 2019-03-28
EP2320740A1 (en) 2011-05-18
US20120322835A1 (en) 2012-12-20
KR20110060889A (ko) 2011-06-08
US11058672B2 (en) 2021-07-13
BRPI0916936A8 (pt) 2017-12-19
BRPI0916936B8 (pt) 2021-05-25
JP5674660B2 (ja) 2015-02-25
DK2320740T3 (da) 2014-06-30
BRPI0916936B1 (pt) 2020-08-04
SMT201400081B (it) 2014-09-08
WO2010014727A1 (en) 2010-02-04
US20100113534A1 (en) 2010-05-06
EA201170289A1 (ru) 2011-10-31
JP2011529900A (ja) 2011-12-15
CA3108961A1 (en) 2010-02-04
HRP20140434T1 (hr) 2014-08-01
CA2732760A1 (en) 2010-02-04
AU2009276560B2 (en) 2015-04-16
US20140005233A1 (en) 2014-01-02
EA021336B1 (ru) 2015-05-29
MX2011001240A (es) 2011-08-12
ES2468837T3 (es) 2014-06-17
EP2719386A1 (en) 2014-04-16
AU2009276560A1 (en) 2010-02-04

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