CY1116458T1 - Ανθρωπινα αντισωματα anti-cd38 και οι χρησεις εξ' αυτων - Google Patents
Ανθρωπινα αντισωματα anti-cd38 και οι χρησεις εξ' αυτωνInfo
- Publication number
- CY1116458T1 CY1116458T1 CY20151100576T CY151100576T CY1116458T1 CY 1116458 T1 CY1116458 T1 CY 1116458T1 CY 20151100576 T CY20151100576 T CY 20151100576T CY 151100576 T CY151100576 T CY 151100576T CY 1116458 T1 CY1116458 T1 CY 1116458T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- provides
- malignancies
- role
- antigen
- Prior art date
Links
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 abstract 3
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010066476 Haematological malignancy Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54191104P | 2004-02-06 | 2004-02-06 | |
| US54758404P | 2004-02-26 | 2004-02-26 | |
| US55394804P | 2004-03-18 | 2004-03-18 | |
| US59901404P | 2004-08-06 | 2004-08-06 | |
| US61447104P | 2004-10-01 | 2004-10-01 | |
| EP11196172.8A EP2511297B1 (en) | 2004-02-06 | 2005-02-07 | Anti-CD38 human antibodies and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116458T1 true CY1116458T1 (el) | 2017-03-15 |
Family
ID=37054659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100576T CY1116458T1 (el) | 2004-02-06 | 2015-07-02 | Ανθρωπινα αντισωματα anti-cd38 και οι χρησεις εξ' αυτων |
Country Status (18)
| Country | Link |
|---|---|
| EP (3) | EP1720907B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP2008504013A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20140066259A (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0507489A (cg-RX-API-DMAC7.html) |
| CY (1) | CY1116458T1 (cg-RX-API-DMAC7.html) |
| DK (2) | DK2511297T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2541489T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20150641T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE025369T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL177242A (cg-RX-API-DMAC7.html) |
| ME (1) | ME02245B (cg-RX-API-DMAC7.html) |
| NO (1) | NO20063986L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ548990A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2511297T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2511297E (cg-RX-API-DMAC7.html) |
| RS (1) | RS54056B1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG142330A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005103083A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| JP2008504013A (ja) | 2004-02-06 | 2008-02-14 | モルフォシス・アクチェンゲゼルシャフト | 抗ｃｄ３８ヒト抗体及びその用途 |
| US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| US8263746B2 (en) | 2004-02-06 | 2012-09-11 | Morphosys Ag | Anti-CD38 human antibodies and uses thereof |
| NZ586780A (en) | 2005-03-23 | 2012-02-24 | Genmab As | Antibodies against CD38 for treatment of multiple myeloma |
| KR20150139636A (ko) * | 2005-10-12 | 2015-12-11 | 모르포시스 아게 | 인간 ｃｄ38에 특이적인 완전 인간 ｈｕｃａｌ ｇｏｌｄ-유도 치료 항체들의 생성 및 프로파일링 |
| DK2548577T3 (en) * | 2005-12-29 | 2017-03-13 | Janssen Biotech Inc | HUMAN ANTI-IL-23 ANTIBODIES, COMPOSITIONS, PROCEDURES AND APPLICATIONS |
| JP5328018B2 (ja) * | 2006-06-05 | 2013-10-30 | 国立大学法人広島大学 | 抗ｃｄ３８抗体を細胞表面に有する免疫担当細胞 |
| EP3753576A1 (en) * | 2006-09-26 | 2020-12-23 | Genmab A/S | Combination treatment of cd38-expressing tumors |
| AU2013209322A1 (en) * | 2006-10-19 | 2013-08-15 | Sanofi-Aventis | Novel anti-cd38 antibodies for the treatment of cancer |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| EP2191841A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
| EP2191840A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
| WO2010079189A1 (en) | 2009-01-09 | 2010-07-15 | Morphosys Ag | Display vectors and methods and uses thereof |
| RS59769B1 (sr) | 2010-06-09 | 2020-02-28 | Genmab As | Antitela protiv humanog cd38 |
| KR101912957B1 (ko) | 2010-09-27 | 2018-10-29 | 모르포시스 아게 | 다발성 골수종 및 nhl 치료를 위한 항-cd38 항체 및 레날리도마이드 또는 보르테조밉 |
| BR112013008255A2 (pt) * | 2010-10-05 | 2018-09-25 | Daiichi Sankyo Co Ltd | anticorpo isolado ou um fragmento funcional do mesmo, uso de um anticorpo isolado ou de um fragmento funcional do mesmo, composição farmacêutica, polinucleotídeo, vetor, célula transformada, e, método para produzir anticorpo |
| UA112170C2 (uk) | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| ES3033729T3 (en) | 2011-10-28 | 2025-08-07 | Teva Pharmaceuticals Australia Pty Ltd | Polypeptide constructs and uses thereof |
| SG11201502163QA (en) | 2012-09-25 | 2015-04-29 | Morphosys Ag | Combinations and uses thereof |
| ES2621377T3 (es) | 2012-11-05 | 2017-07-03 | Morphosys Ag | Anticuerpo marcado radiactivamente y usos del mismo |
| JP2014117191A (ja) * | 2012-12-13 | 2014-06-30 | Fisheries Research Agency | リン酸化中性スフィンゴミエリナーゼ１、抗リン酸化中性スフィンゴミエリナーゼ１抗体、中性スフィンゴミエリナーゼ１変異体、及びそれらの用途 |
| HRP20191865T1 (hr) | 2013-01-14 | 2020-01-10 | Xencor, Inc. | Novi heterodimerni proteini |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| PT3677591T (pt) * | 2013-04-29 | 2023-02-17 | Teva Pharmaceuticals Australia Pty Ltd | Anticorpos anti-cd38 e fusões a interferão alfa-2b atenuado |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| EP3176185A1 (en) | 2013-11-04 | 2017-06-07 | Glenmark Pharmaceuticals S.A. | Production of t cell retargeting hetero-dimeric immunoglobulins |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| SG11201607983YA (en) * | 2014-03-28 | 2016-10-28 | Xencor Inc | Bispecific antibodies that bind to cd38 and cd3 |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
| EP3154581B1 (en) | 2014-06-16 | 2019-02-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Blocking cd38 using anti-cd38 f(ab')2 to protect nk cells |
| WO2015195555A1 (en) | 2014-06-16 | 2015-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Blocking cd38 using anti-cd38 antibody conjugated to protein g to protect nk cells |
| PH12017500442B1 (en) | 2014-09-09 | 2023-05-24 | Janssen Biotech Inc | Combination therapies with anti-cd38 antibodies |
| PE20170908A1 (es) | 2014-10-29 | 2017-07-12 | Teva Pharmaceuticals Australia Pty Ltd | VARIANTES DE INTERFERON a2b |
| HUE054526T2 (hu) | 2014-10-29 | 2021-09-28 | Bicyclerd Ltd | MT1-MMP-ra specifikus biciklusos peptid ligandumok |
| MA40894A (fr) * | 2014-11-04 | 2017-09-12 | Glenmark Pharmaceuticals Sa | Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production |
| US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
| RS62332B1 (sr) | 2014-11-26 | 2021-10-29 | Xencor Inc | Heterodimerna antitela koja vezuju cd3 i cd20 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CN107406512A (zh) | 2014-11-26 | 2017-11-28 | Xencor公司 | 结合cd3和cd38的异二聚体抗体 |
| IL307913A (en) | 2014-12-04 | 2023-12-01 | Janssen Biotech Inc | Anti-CD38 antibodies for the treatment of acute myeloid leukemia |
| EP3280443B1 (en) * | 2015-04-08 | 2022-08-24 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd38 |
| PT3294769T (pt) | 2015-05-13 | 2021-04-13 | Morphosys Ag | Tratamento para mieloma múltiplo (mm) |
| CN108136218B (zh) | 2015-05-20 | 2022-12-13 | 詹森生物科技公司 | 用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体 |
| MX2017015493A (es) | 2015-05-30 | 2018-02-09 | Molecular Templates Inc | Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden. |
| PE20181323A1 (es) | 2015-06-22 | 2018-08-14 | Janssen Biotech Inc | Terapias de combinacion para enfermedades malignas hematologicas con anticuerpos anti-cd38 e inhibidores de survivina |
| PT3313441T (pt) | 2015-06-24 | 2024-05-07 | Janssen Biotech Inc | Modulação imunitária e tratamento de tumores sólidos com anticorpos que se ligam especificamente a cd38 |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| HUE053366T2 (hu) | 2015-11-03 | 2021-06-28 | Janssen Biotech Inc | Szubkután anti-CD38-ellenanyag-készítmények és alkalmazásuk |
| AU2017226960B2 (en) | 2016-03-04 | 2024-03-21 | Morphosys Ag | Clinical assessment of M-protein response in multiple myeloma |
| CN116063545A (zh) | 2016-06-28 | 2023-05-05 | Xencor股份有限公司 | 结合生长抑素受体2的异源二聚抗体 |
| EP3474895A1 (en) | 2016-06-28 | 2019-05-01 | UMC Utrecht Holding B.V. | TREATMENT OF IgE-MEDIATED DISEASES WITH ANTIBODIES THAT SPECIFICALLY BIND CD38 |
| US10478497B2 (en) | 2016-07-20 | 2019-11-19 | Hybrigenics S.A. | Combinations of inecalcitol with an anti-CD38 agent and their uses for treating cancer |
| CA3066547A1 (en) | 2017-06-08 | 2018-12-13 | Black Belt Therapeutics Limited | Cd38 modulating antibody |
| AU2018280871B2 (en) | 2017-06-08 | 2024-09-26 | Black Belt Therapeutics Ltd | CD38 modulating antibody |
| EP3641831B1 (en) | 2017-06-20 | 2024-11-06 | Sorrento Therapeutics, Inc. | Cd38 antibody drug conjugate |
| CN111032678A (zh) | 2017-06-26 | 2020-04-17 | 拜西克尔德有限公司 | 具有可检测部分的双环肽配体和其用途 |
| EP3661948B1 (en) | 2017-08-04 | 2022-06-01 | BicycleTx Limited | Bicyclic peptide ligands specific for cd137 |
| CA3073085A1 (en) | 2017-08-16 | 2019-02-21 | Black Belt Therapeutics Limited | Cd38 modulating antibody |
| CA3072296A1 (en) | 2017-08-16 | 2019-02-21 | Black Belt Therapeutics Limited | Cd38 antibody |
| US11542338B2 (en) | 2017-08-16 | 2023-01-03 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| CA3078800A1 (en) * | 2017-10-10 | 2019-04-18 | Sanofi | Anti-cd38 antibodies and methods of use |
| CN111565751A (zh) | 2017-10-31 | 2020-08-21 | 詹森生物科技公司 | 治疗高危多发性骨髓瘤的方法 |
| CN112272563A (zh) | 2017-11-08 | 2021-01-26 | Xencor股份有限公司 | 使用新颖抗pd-1序列的双特异性和单特异性抗体 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| AU2019216269B2 (en) | 2018-01-30 | 2025-05-01 | Cellectis | Combination comprising allogeneic immune cells deficient for an antigen present on both T-cells and pathological cells and therapeutic antibody against said antigen |
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2005
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- 2005-02-07 DK DK11196172.8T patent/DK2511297T3/en active
- 2005-02-07 ES ES11196172.8T patent/ES2541489T3/es not_active Expired - Lifetime
- 2005-02-07 PL PL11196172T patent/PL2511297T3/pl unknown
- 2005-02-07 WO PCT/IB2005/002476 patent/WO2005103083A2/en not_active Ceased
- 2005-02-07 KR KR1020147011314A patent/KR20140066259A/ko not_active Withdrawn
- 2005-02-07 SG SG200803286-4A patent/SG142330A1/en unknown
- 2005-02-07 NZ NZ548990A patent/NZ548990A/en not_active IP Right Cessation
- 2005-02-07 ES ES05769690.8T patent/ES2541436T3/es not_active Expired - Lifetime
- 2005-02-07 EP EP05769690.8A patent/EP1720907B1/en not_active Expired - Lifetime
- 2005-02-07 HU HUE11196172A patent/HUE025369T2/en unknown
- 2005-02-07 RS RS20150390A patent/RS54056B1/sr unknown
- 2005-02-07 EP EP11196172.8A patent/EP2511297B1/en not_active Revoked
- 2005-02-07 PT PT111961728T patent/PT2511297E/pt unknown
- 2005-02-07 DK DK05769690.8T patent/DK1720907T3/en active
- 2005-02-07 KR KR1020137028482A patent/KR20130126747A/ko not_active Abandoned
- 2005-02-07 EP EP15151492.4A patent/EP2915820A1/en not_active Ceased
- 2005-02-07 BR BRPI0507489-4A patent/BRPI0507489A/pt not_active Application Discontinuation
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2006
- 2006-08-02 IL IL177242A patent/IL177242A/en active IP Right Grant
- 2006-09-05 NO NO20063986A patent/NO20063986L/no not_active Application Discontinuation
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2012
- 2012-02-03 JP JP2012022417A patent/JP5926568B2/ja not_active Expired - Fee Related
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2015
- 2015-01-05 JP JP2015000102A patent/JP2015110597A/ja active Pending
- 2015-06-15 HR HRP20150641TT patent/HRP20150641T1/hr unknown
- 2015-07-02 CY CY20151100576T patent/CY1116458T1/el unknown
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2016
- 2016-05-17 ME MEP-2015-350A patent/ME02245B/me unknown
- 2016-06-03 JP JP2016111794A patent/JP2016164198A/ja active Pending
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| WO2005103083A8 (en) | 2006-10-05 |
| HK1097859A1 (en) | 2007-07-06 |
| SG142330A1 (en) | 2008-05-28 |
| PT2511297E (pt) | 2015-08-24 |
| IL177242A (en) | 2011-09-27 |
| ES2541489T3 (es) | 2015-07-21 |
| DK2511297T3 (en) | 2015-06-15 |
| NZ548990A (en) | 2009-06-26 |
| JP5926568B2 (ja) | 2016-05-25 |
| HUE025369T2 (en) | 2016-02-29 |
| ME02245B (me) | 2015-10-30 |
| NO20063986L (no) | 2006-11-06 |
| JP2015110597A (ja) | 2015-06-18 |
| RS54056B1 (sr) | 2015-10-30 |
| ES2541436T3 (es) | 2015-07-20 |
| IL177242A0 (en) | 2006-12-10 |
| EP2511297A1 (en) | 2012-10-17 |
| EP1720907A2 (en) | 2006-11-15 |
| BRPI0507489A (pt) | 2007-07-10 |
| HRP20150641T1 (hr) | 2015-07-17 |
| JP2012116856A (ja) | 2012-06-21 |
| JP2016164198A (ja) | 2016-09-08 |
| PL2511297T3 (pl) | 2015-08-31 |
| EP2511297B1 (en) | 2015-04-08 |
| DK1720907T3 (en) | 2015-06-15 |
| JP2008504013A (ja) | 2008-02-14 |
| KR20140066259A (ko) | 2014-05-30 |
| WO2005103083A3 (en) | 2006-11-16 |
| KR20130126747A (ko) | 2013-11-20 |
| EP2915820A1 (en) | 2015-09-09 |
| EP1720907B1 (en) | 2015-04-08 |
| WO2005103083A2 (en) | 2005-11-03 |
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