CY1116458T1 - Ανθρωπινα αντισωματα anti-cd38 και οι χρησεις εξ' αυτων - Google Patents
Ανθρωπινα αντισωματα anti-cd38 και οι χρησεις εξ' αυτωνInfo
- Publication number
- CY1116458T1 CY1116458T1 CY20151100576T CY151100576T CY1116458T1 CY 1116458 T1 CY1116458 T1 CY 1116458T1 CY 20151100576 T CY20151100576 T CY 20151100576T CY 151100576 T CY151100576 T CY 151100576T CY 1116458 T1 CY1116458 T1 CY 1116458T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- provides
- malignancies
- role
- antigen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ανασυνδυασμένες περιοχές δέσμευσης-αντιγόνων και αντισώματα και λειτουργικά θραύσματα που περιέχουν τέτοιες περιοχές δέσμευσης-αντιγόνων που είναι συγκεκριμένες για το CD38, το οποίο διαδραματίζει ολοκληρωτικό ρόλο σε διάφορες διαταραχές ή καταστάσεις. Αυτά τα αντισώματα, συνεπώς, μπορούν να χρησιμοποιηθούν για την αγωγή, για παράδειγμα, αιματολογικών κακοηθειών όπως είναι το πολλαπλό μυέλωμα. Τα αντισώματα της εφεύρεσης μπορούν επίσης να χρησιμοποιηθούν και στο διαγνωστικό πεδίο, ως επίσης και για διερεύνηση του ρόλου του CD38 στην πρόοδο διαταραχών που συσχετίζονται με κακοήθειες. Η εφεύρεση παρέχει επίσης και αλληλουχίες πυρηνικών οξέων που εγκωδικεύουν τα προειρημένα αντισώματα, ανύσματα που περιέχουν τα ίδια, φαρμακευτικές συνθέσεις και κιτ με οδηγίες για χρήση. Η εφεύρεση παρέχει επίσης και απομονωμένους καινοφανείς επίτοπους του CD38 και μεθόδους για χρήση ως εκ τούτου.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54191104P | 2004-02-06 | 2004-02-06 | |
US54758404P | 2004-02-26 | 2004-02-26 | |
US55394804P | 2004-03-18 | 2004-03-18 | |
US59901404P | 2004-08-06 | 2004-08-06 | |
US61447104P | 2004-10-01 | 2004-10-01 | |
EP11196172.8A EP2511297B1 (en) | 2004-02-06 | 2005-02-07 | Anti-CD38 human antibodies and uses therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116458T1 true CY1116458T1 (el) | 2017-03-15 |
Family
ID=37054659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100576T CY1116458T1 (el) | 2004-02-06 | 2015-07-02 | Ανθρωπινα αντισωματα anti-cd38 και οι χρησεις εξ' αυτων |
Country Status (19)
Country | Link |
---|---|
EP (3) | EP2511297B1 (el) |
JP (4) | JP2008504013A (el) |
KR (2) | KR20140066259A (el) |
BR (1) | BRPI0507489A (el) |
CY (1) | CY1116458T1 (el) |
DK (2) | DK1720907T3 (el) |
ES (2) | ES2541489T3 (el) |
HK (1) | HK1097859A1 (el) |
HR (1) | HRP20150641T1 (el) |
HU (1) | HUE025369T2 (el) |
IL (1) | IL177242A (el) |
ME (1) | ME02245B (el) |
NO (1) | NO20063986L (el) |
NZ (1) | NZ548990A (el) |
PL (1) | PL2511297T3 (el) |
PT (1) | PT2511297E (el) |
RS (1) | RS54056B1 (el) |
SG (1) | SG142330A1 (el) |
WO (1) | WO2005103083A2 (el) |
Families Citing this family (95)
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EP2511297B1 (en) | 2004-02-06 | 2015-04-08 | MorphoSys AG | Anti-CD38 human antibodies and uses therefor |
US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
AU2005235811B2 (en) | 2004-02-06 | 2011-11-03 | Morphosys Ag | Anti-CD38 human antibodies and uses therefor |
US7829673B2 (en) | 2005-03-23 | 2010-11-09 | Genmab A/S | Antibodies against CD38 for treatment of multiple myeloma |
EP2860192B1 (en) * | 2005-10-12 | 2017-09-27 | MorphoSys AG | Generation and profiling of fully human HuCAL GOLD-derived therapeutic antibodies specific for human CD38 |
HUE034269T2 (en) | 2005-12-29 | 2018-02-28 | Janssen Biotech Inc | Human anti-IL-23 antibodies, preparations, methods and applications |
JP5328018B2 (ja) * | 2006-06-05 | 2013-10-30 | 国立大学法人広島大学 | 抗cd38抗体を細胞表面に有する免疫担当細胞 |
SI2081595T1 (sl) | 2006-09-26 | 2019-10-30 | Genmab As | Anti-cd38 plus kortikosteroidi plus ne-kortikosteroidni kemoterapevtik za zdravljenje tumorjev |
AU2013209322A1 (en) * | 2006-10-19 | 2013-08-15 | Sanofi-Aventis | Novel anti-cd38 antibodies for the treatment of cancer |
EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
EP2191840A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
EP2191841A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
WO2010079189A1 (en) | 2009-01-09 | 2010-07-15 | Morphosys Ag | Display vectors and methods and uses thereof |
PL2580243T3 (pl) | 2010-06-09 | 2020-05-18 | Genmab A/S | Przeciwciała przeciwko ludzkiemu CD38 |
SG188345A1 (en) | 2010-09-27 | 2013-04-30 | Morphosys Ag | Anti-cd38 antibody and lenalidomide or bortezomib for the treatment of multiple myeloma and nhl |
EP2625205A2 (en) * | 2010-10-05 | 2013-08-14 | Daiichi Sankyo Company, Limited | Antibody targeting osteoclast-related protein siglec-15 |
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CN109022465B (zh) | 2011-10-28 | 2022-04-29 | 特瓦制药澳大利亚私人有限公司 | 多肽构建体及其用途 |
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CN105051069B (zh) | 2013-01-14 | 2019-12-10 | Xencor股份有限公司 | 新型异二聚体蛋白 |
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US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
KR102094022B1 (ko) * | 2013-04-29 | 2020-03-30 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 항-cd38 항체 및 감쇠 인터페론 알파-2b와의 융합체 |
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2005
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- 2005-02-07 EP EP05769690.8A patent/EP1720907B1/en active Active
- 2005-02-07 EP EP15151492.4A patent/EP2915820A1/en not_active Ceased
- 2005-02-07 NZ NZ548990A patent/NZ548990A/en not_active IP Right Cessation
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- 2005-02-07 HU HUE11196172A patent/HUE025369T2/en unknown
- 2005-02-07 ES ES11196172.8T patent/ES2541489T3/es active Active
- 2005-02-07 KR KR1020147011314A patent/KR20140066259A/ko not_active Application Discontinuation
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- 2005-02-07 KR KR1020137028482A patent/KR20130126747A/ko not_active IP Right Cessation
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- 2005-02-07 ES ES05769690.8T patent/ES2541436T3/es active Active
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- 2005-02-07 BR BRPI0507489-4A patent/BRPI0507489A/pt not_active Application Discontinuation
- 2005-02-07 PT PT111961728T patent/PT2511297E/pt unknown
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2006
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- 2015-06-15 HR HRP20150641TT patent/HRP20150641T1/hr unknown
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JP2012116856A (ja) | 2012-06-21 |
PT2511297E (pt) | 2015-08-24 |
DK2511297T3 (en) | 2015-06-15 |
HK1097859A1 (en) | 2007-07-06 |
EP2915820A1 (en) | 2015-09-09 |
WO2005103083A8 (en) | 2006-10-05 |
EP2511297B1 (en) | 2015-04-08 |
ES2541436T3 (es) | 2015-07-20 |
ME02245B (me) | 2015-10-30 |
IL177242A (en) | 2011-09-27 |
PL2511297T3 (pl) | 2015-08-31 |
JP2016164198A (ja) | 2016-09-08 |
DK1720907T3 (en) | 2015-06-15 |
JP2015110597A (ja) | 2015-06-18 |
KR20130126747A (ko) | 2013-11-20 |
ES2541489T3 (es) | 2015-07-21 |
NO20063986L (no) | 2006-11-06 |
IL177242A0 (en) | 2006-12-10 |
HUE025369T2 (en) | 2016-02-29 |
JP5926568B2 (ja) | 2016-05-25 |
KR20140066259A (ko) | 2014-05-30 |
EP1720907A2 (en) | 2006-11-15 |
HRP20150641T1 (hr) | 2015-07-17 |
EP1720907B1 (en) | 2015-04-08 |
JP2008504013A (ja) | 2008-02-14 |
RS54056B1 (en) | 2015-10-30 |
WO2005103083A3 (en) | 2006-11-16 |
EP2511297A1 (en) | 2012-10-17 |
WO2005103083A2 (en) | 2005-11-03 |
BRPI0507489A (pt) | 2007-07-10 |
NZ548990A (en) | 2009-06-26 |
SG142330A1 (en) | 2008-05-28 |
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