CY1115341T1 - Μεθοδοι ενδοκυτταρικης μετατροπης πρωτεϊνων μονης αλυσιδας προς τη μορφη διπλης αλυσιδας αυτων - Google Patents
Μεθοδοι ενδοκυτταρικης μετατροπης πρωτεϊνων μονης αλυσιδας προς τη μορφη διπλης αλυσιδας αυτωνInfo
- Publication number
- CY1115341T1 CY1115341T1 CY20141100528T CY141100528T CY1115341T1 CY 1115341 T1 CY1115341 T1 CY 1115341T1 CY 20141100528 T CY20141100528 T CY 20141100528T CY 141100528 T CY141100528 T CY 141100528T CY 1115341 T1 CY1115341 T1 CY 1115341T1
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- Cyprus
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- methods
- intellacycular
- double chain
- single chain
- double
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα περιγραφή αποκαλύπτει κατασκευάσματα έκφρασης τα οποία περιλαμβάνουν πρωτεΐνες μονής αλυσίδας, οι οποίες περιλαμβάνουν μία περιοχή βρόχου διπλής αλυσίδας, η οποία περιλαμβάνει μία εξωγενή θέση διάσπασης πρωτεάσης και μία πρωτεάση η οποία είναι δυνατόν να διασπά την εξωγενή θέση διάσπασης πρωτεάσης, η οποία ευρίσκεται εντός του βρόχου διπλής αλυσίδας, κυτταρικές συνθέσεις οι οποίες περιλαμβάνουν τέτοιο κατασκεύασμα έκφρασης και ενδοκυτταρικές μεθόδους μετατροπής της πρωτεΐνης μονής αλυσίδας προς τη μορφή διπλής αλυσίδας αυτής.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28696310P | 2010-01-25 | 2010-01-25 | |
EP11702755.7A EP2528940B1 (en) | 2010-01-25 | 2011-01-24 | Methods of intracellular conversion of single-chain proteins into their di-chain form |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115341T1 true CY1115341T1 (el) | 2017-01-04 |
Family
ID=44146329
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100528T CY1115341T1 (el) | 2010-01-25 | 2014-07-11 | Μεθοδοι ενδοκυτταρικης μετατροπης πρωτεϊνων μονης αλυσιδας προς τη μορφη διπλης αλυσιδας αυτων |
CY20161100700T CY1117797T1 (el) | 2010-01-25 | 2016-07-19 | Μεθοδοι ενδοκυτταρικης μετατροπης πρωτεϊνων μονης αλυσιδας προς τη μορφη διπλης αλυσιδας αυτων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100700T CY1117797T1 (el) | 2010-01-25 | 2016-07-19 | Μεθοδοι ενδοκυτταρικης μετατροπης πρωτεϊνων μονης αλυσιδας προς τη μορφη διπλης αλυσιδας αυτων |
Country Status (24)
Country | Link |
---|---|
US (3) | US8546108B2 (el) |
EP (3) | EP3034511A1 (el) |
JP (2) | JP5956350B2 (el) |
KR (1) | KR101930962B1 (el) |
CN (1) | CN102822196B (el) |
AU (1) | AU2016204285B2 (el) |
BR (1) | BR112012018526A2 (el) |
CA (1) | CA2788074C (el) |
CL (1) | CL2012002087A1 (el) |
CY (2) | CY1115341T1 (el) |
DK (1) | DK2528940T3 (el) |
ES (2) | ES2592856T3 (el) |
HK (1) | HK1179634A1 (el) |
HU (1) | HUE029962T2 (el) |
IL (2) | IL221095A (el) |
MX (1) | MX2012008650A (el) |
NZ (1) | NZ601472A (el) |
PL (2) | PL2684890T3 (el) |
PT (2) | PT2528940E (el) |
RU (1) | RU2569185C2 (el) |
SG (1) | SG182691A1 (el) |
SI (2) | SI2684890T1 (el) |
WO (1) | WO2011091370A1 (el) |
ZA (1) | ZA201205793B (el) |
Families Citing this family (20)
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CN102822196B (zh) * | 2010-01-25 | 2014-12-17 | 阿勒根公司 | 将单链蛋白质细胞内转化成它们的双链形式的方法 |
KR101134146B1 (ko) | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
US9096886B2 (en) * | 2011-03-11 | 2015-08-04 | Merz Pharma Gmbh & Co. Kgaa | Method for the determination of botulinum neurotoxin biological activity |
US9764009B2 (en) | 2011-06-13 | 2017-09-19 | Allergan, Inc. | Treatment of psychological trauma |
RU2673910C2 (ru) * | 2012-11-21 | 2018-12-03 | Ипсен Байоинновейшн Лимитед | Способ производства протеолитически процессированного полипептида |
DK3242884T3 (da) * | 2015-01-09 | 2021-04-19 | Ipsen Bioinnovation Ltd | Kationiske neurotoksiner |
RU2627181C2 (ru) * | 2015-12-29 | 2017-08-03 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Экспрессионный плазмидный лентивирусный вектор для гетерологичной экспрессии рекомбинантного человеческого белка cd47 |
US10308927B2 (en) | 2017-01-17 | 2019-06-04 | The United States of America, as Represented by the Secretary of Homeland Security | Processing of a modified foot-and-mouth disease virus P1 polypeptide by an alternative protease |
CN109055339B (zh) * | 2018-09-19 | 2020-09-01 | 生工生物工程(上海)股份有限公司 | Tev蛋白酶突变体、基因、生物材料、制备方法、试剂或试剂盒和应用 |
CN111019926B (zh) * | 2018-10-10 | 2021-11-26 | 上饶市康可得生物科技有限公司 | Tev蛋白酶变体、其融合蛋白及制备方法和用途 |
EP3851524A4 (en) * | 2018-10-10 | 2022-05-18 | Shangrao Concord Pharmaceutical Co., Ltd. | PROTEASE VARIANT SCREENING METHOD AND PROTEASE VARIANT OBTAINED |
CN111019925B (zh) * | 2018-10-10 | 2022-08-23 | 上饶市康可得生物科技有限公司 | 筛选蛋白酶变体的方法以及获得的蛋白酶变体 |
JP7296660B2 (ja) * | 2018-10-10 | 2023-06-23 | 上饒市康可得生物科技有限公司 | Tevプロテアーゼバリアント、その融合タンパク質、調製方法および使用 |
KR20200080749A (ko) * | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법 |
JP6867452B2 (ja) * | 2019-08-09 | 2021-04-28 | イプセン バイオイノベーション リミテッド | 陽イオン性神経毒 |
WO2021062063A1 (en) * | 2019-09-26 | 2021-04-01 | Chan Zuckerberg Biohub, Inc. | Improved variants of tev protease for biotechnological applications |
CN113801866B (zh) * | 2021-09-02 | 2022-08-16 | 无锡佰翱得生物科学有限公司 | 一种高效表达具有高活性及稳定性的重组tev酶及其制备方法和应用 |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
EP4321618A1 (en) * | 2022-08-09 | 2024-02-14 | NUMAFERM GmbH | Variants of tev protease and uses thereof |
CN116640196B (zh) * | 2023-05-10 | 2024-02-06 | 山东农业大学 | 囊泡相关膜蛋白的相关蛋白vap1在抗马铃薯y病毒中的应用 |
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CN102822196B (zh) * | 2010-01-25 | 2014-12-17 | 阿勒根公司 | 将单链蛋白质细胞内转化成它们的双链形式的方法 |
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2011
- 2011-01-24 CN CN201180014965.0A patent/CN102822196B/zh not_active Expired - Fee Related
- 2011-01-24 ES ES13188050.2T patent/ES2592856T3/es active Active
- 2011-01-24 PT PT117027557T patent/PT2528940E/pt unknown
- 2011-01-24 MX MX2012008650A patent/MX2012008650A/es active IP Right Grant
- 2011-01-24 JP JP2012551218A patent/JP5956350B2/ja not_active Expired - Fee Related
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