CY1114171T1 - Συζευγματα αλλεργιογονων γατας και χρησεις τους - Google Patents
Συζευγματα αλλεργιογονων γατας και χρησεις τουςInfo
- Publication number
- CY1114171T1 CY1114171T1 CY20131100638T CY131100638T CY1114171T1 CY 1114171 T1 CY1114171 T1 CY 1114171T1 CY 20131100638 T CY20131100638 T CY 20131100638T CY 131100638 T CY131100638 T CY 131100638T CY 1114171 T1 CY1114171 T1 CY 1114171T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cat
- antigen
- compositions
- vlp
- conjunctions
- Prior art date
Links
- 230000002009 allergenic effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 6
- 102000036639 antigens Human genes 0.000 abstract 6
- 108091007433 antigens Proteins 0.000 abstract 6
- 241000282326 Felis catus Species 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 239000013566 allergen Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 208000001840 Dandruff Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000005180 public health Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66291805P | 2005-03-18 | 2005-03-18 | |
| EP06725140.5A EP1868642B1 (en) | 2005-03-18 | 2006-03-17 | Cat allergen fusion proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114171T1 true CY1114171T1 (el) | 2016-08-31 |
Family
ID=36843236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100638T CY1114171T1 (el) | 2005-03-18 | 2013-07-26 | Συζευγματα αλλεργιογονων γατας και χρησεις τους |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7767212B2 (OSRAM) |
| EP (1) | EP1868642B1 (OSRAM) |
| JP (2) | JP5302671B2 (OSRAM) |
| KR (1) | KR20070112225A (OSRAM) |
| CN (2) | CN101141979B (OSRAM) |
| AU (1) | AU2006224529B2 (OSRAM) |
| BR (1) | BRPI0608455A2 (OSRAM) |
| CA (1) | CA2599218C (OSRAM) |
| CY (1) | CY1114171T1 (OSRAM) |
| DK (1) | DK1868642T3 (OSRAM) |
| ES (1) | ES2424229T3 (OSRAM) |
| IL (1) | IL185103A0 (OSRAM) |
| MX (1) | MX2007011160A (OSRAM) |
| NZ (1) | NZ561040A (OSRAM) |
| PL (1) | PL1868642T3 (OSRAM) |
| PT (1) | PT1868642E (OSRAM) |
| RU (1) | RU2414239C2 (OSRAM) |
| WO (1) | WO2006097530A2 (OSRAM) |
| ZA (1) | ZA200707413B (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
| CN102061288A (zh) * | 2002-07-17 | 2011-05-18 | 希托斯生物技术股份公司 | 使用衍生自ap205外壳蛋白的病毒样颗粒的分子抗原阵列 |
| CA2492930C (en) * | 2002-07-19 | 2013-01-08 | Cytos Biotechnology Ag | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| NZ561040A (en) * | 2005-03-18 | 2009-04-30 | Cytos Biotechnology Ag | Cat allergen fusion proteins and use thereof |
| CA2636139A1 (en) * | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| WO2007113633A2 (en) * | 2006-04-03 | 2007-10-11 | Pfizer Products Inc. | Immunogenic compositions comprising cat allergen fel dl |
| AT503690A1 (de) * | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| EP2530086B1 (en) | 2006-06-12 | 2019-03-20 | Kuros Biosciences AG | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
| AU2007303608B2 (en) | 2006-09-29 | 2013-05-02 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| US9388236B2 (en) | 2007-07-09 | 2016-07-12 | Nestec Sa | Methods for reducing allergies caused by environmental allergens |
| DK2162133T3 (en) | 2007-07-09 | 2016-10-24 | Nestec Sa | Approaches to reduce allergies caused by environmental allergens |
| CN101918028B (zh) | 2007-09-18 | 2015-01-07 | 莱戈赛特医药股份有限公司 | 赋予针对诺如病毒的保护性免疫应答的疫苗 |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| EP2042193A1 (en) * | 2007-09-28 | 2009-04-01 | Biomay AG | RNA Vaccines |
| JP5852883B2 (ja) | 2008-08-08 | 2016-02-03 | タケダ ワクチン，インコーポレイテッド | 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子 |
| DE112010006063B4 (de) * | 2009-11-05 | 2018-12-27 | Novici Biotech Llc | Erzeugung von Antigenen, virusartigen Partikeln über Protein-Protein-Bindungen |
| US8321012B2 (en) * | 2009-12-22 | 2012-11-27 | The Invention Science Fund I, Llc | Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject |
| DK3299030T3 (da) | 2011-07-11 | 2022-09-05 | Takeda Vaccines Inc | Parenterale norovirus-vaccineformuleringer |
| CA2854246A1 (en) | 2011-12-22 | 2013-06-27 | F. Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use |
| JO3820B1 (ar) * | 2012-05-03 | 2021-01-31 | Regeneron Pharma | أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها |
| US9657076B2 (en) * | 2012-10-23 | 2017-05-23 | Emory University | GM-CSF and IL-4 conjugates, compositions, and methods related thereto |
| WO2015027154A2 (en) | 2013-08-23 | 2015-02-26 | Regeneron Pharmaceuticals, Inc. | Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit) |
| US20150175940A1 (en) * | 2013-12-19 | 2015-06-25 | Nestec Sa | Compositions and methods for reducing cat allergens in the environment |
| MA40824A (fr) | 2014-10-22 | 2017-08-29 | Saiba Gmbh | Particules de cmv de type virus modifié |
| EA035378B1 (ru) | 2015-01-15 | 2020-06-04 | Юниверсити Оф Копенгаген | Вирусоподобная частица с эффективным экспонированием эпитопов |
| WO2016192788A1 (en) * | 2015-06-03 | 2016-12-08 | Universität Zürich Prorektorat Mnw | Methods and compositions for preventing and treating cat or dog dander allergy |
| US10835600B2 (en) * | 2015-09-08 | 2020-11-17 | Universität Zürich | Compositions against cat allergy |
| DK3368068T3 (da) | 2015-10-30 | 2021-02-22 | Univ Copenhagen | Viruslignende partikler med effektiv epitopdisplay |
| CN105219742A (zh) * | 2015-11-10 | 2016-01-06 | 海南大学 | 一种展示重组猫致敏原rFel d 1蛋白的免疫增强型病毒样颗粒、其表达载体及其制备与应用 |
| WO2017179025A1 (en) | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
| FR3054547B1 (fr) * | 2016-07-29 | 2020-06-05 | Angany Inc. | Particules pseudo-virales et leurs utilisations |
| WO2018118713A1 (en) | 2016-12-22 | 2018-06-28 | Regeneron Pharmaceuticals, Inc. | Method of treating an allergy with allergen-specific monoclonal antibodies |
| SG11202104486VA (en) | 2018-12-20 | 2021-05-28 | Saiba AG | Virus-like particles of cmv modified by fusion |
| CN118871591A (zh) * | 2022-03-18 | 2024-10-29 | 电化株式会社 | 包含通过接头连接的衣壳蛋白的病毒样颗粒 |
| CN114933639B (zh) * | 2022-05-05 | 2023-12-29 | 中国农业科学院兰州兽医研究所 | 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途 |
| CN117004650B (zh) * | 2023-06-25 | 2024-05-14 | 山东立菲生物产业有限公司 | 一种猫皮屑过敏原组分feld1双链二聚体重组蛋白、制备方法及应用 |
| WO2025139524A1 (zh) * | 2023-12-28 | 2025-07-03 | 江苏众红生物工程创药研究院有限公司 | 猫重组变应原及其药用组合物、制备方法和应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4163778A (en) * | 1978-05-04 | 1979-08-07 | The Foundation for the Study of Asthma and Related Diseases | Asthma immunotherapy |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| AU633007B2 (en) * | 1988-06-14 | 1993-01-21 | Cell-Sci Corporation | Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same |
| US6120769A (en) * | 1989-11-03 | 2000-09-19 | Immulogic Pharmaceutical Corporation | Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor |
| WO1992011291A1 (en) | 1990-12-20 | 1992-07-09 | Smithkline Beecham Biologicals (S.A.) | Vaccines based on hepatitis b surface antigen |
| GB9114003D0 (en) * | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| US6759234B1 (en) * | 1994-09-02 | 2004-07-06 | Immulogic Pharmaceutical Corporation | Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response |
| AU7726094A (en) | 1994-09-02 | 1996-03-27 | Immulogic Pharmaceutical Corporation | Peptide compositions capable of down regulating an antigen specific immune response |
| CN1185811A (zh) | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| US6054312A (en) * | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| WO1999030736A2 (en) * | 1997-12-16 | 1999-06-24 | Regents Of The University Of Minnesota | Methods to treat undesirable immune responses |
| AR020102A1 (es) | 1998-07-30 | 2002-04-10 | Ucb Sa | Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento |
| WO2000020032A1 (en) | 1998-10-06 | 2000-04-13 | Trustees Of Dartmouth College | RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY |
| JP4486257B2 (ja) * | 1998-10-21 | 2010-06-23 | アメリカ合衆国 | 自己抗体の誘導のためのウイルス様粒子 |
| WO2000032227A2 (en) * | 1998-11-30 | 2000-06-08 | Cytos Biotechnology Ag | Ordered molecular presentation of antigens, method of preparation and use |
| SK287400B6 (sk) | 1999-09-25 | 2010-08-09 | University Of Iowa Research Foundation | Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| DE60136653D1 (de) | 2000-11-16 | 2009-01-02 | Alk Abello As | Mutante allergene |
| DK1219300T3 (da) | 2000-12-28 | 2007-03-05 | Biomay Prod & Handel | Behandling af allergi |
| EP1221317A1 (en) * | 2000-12-28 | 2002-07-10 | SHAN-Beteiligungsgesellschaft m.b.H. | Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins |
| US7320793B2 (en) | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| ATE448793T1 (de) | 2001-03-02 | 2009-12-15 | Univ Rockefeller | Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens |
| ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
| WO2003024480A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| ATE412428T1 (de) * | 2001-11-07 | 2008-11-15 | Cytos Biotechnology Ag | Antigen-raster enthaltend rankl zur behandlung von knochenerkrankungen |
| NZ532516A (en) * | 2001-11-07 | 2008-05-30 | Cytos Biotechnology Ag | Antigen arrays presenting IL-5, IL-13 or eotaxin for treatment of allergic eosinophilic diseases |
| CN102061288A (zh) * | 2002-07-17 | 2011-05-18 | 希托斯生物技术股份公司 | 使用衍生自ap205外壳蛋白的病毒样颗粒的分子抗原阵列 |
| CN1665565A (zh) | 2002-07-19 | 2005-09-07 | 赛托斯生物技术公司 | Ghrelin－载体偶联物 |
| EP1530585A2 (en) * | 2002-08-22 | 2005-05-18 | Cytos Biotechnology AG | Inducible alphaviral/orip based gene expression system |
| WO2004039834A2 (en) | 2002-11-01 | 2004-05-13 | Alk-Abelló A/S | Recombinant protein variants |
| WO2004047793A1 (en) | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
| CA2517839A1 (en) * | 2003-03-26 | 2004-10-07 | Martin F. Bachmann | Melan-a peptide analogue-virus-like-particle conjugates |
| ATE384741T1 (de) * | 2003-04-24 | 2008-02-15 | Imvision Gmbh | Rekombinantes fel d 1 allergen |
| JP2009513532A (ja) * | 2003-07-10 | 2009-04-02 | サイトス バイオテクノロジー アーゲー | パッケージ化ウイルス様粒子 |
| NZ561040A (en) * | 2005-03-18 | 2009-04-30 | Cytos Biotechnology Ag | Cat allergen fusion proteins and use thereof |
-
2006
- 2006-03-17 NZ NZ561040A patent/NZ561040A/en not_active IP Right Cessation
- 2006-03-17 KR KR1020077022225A patent/KR20070112225A/ko not_active Withdrawn
- 2006-03-17 ES ES06725140T patent/ES2424229T3/es active Active
- 2006-03-17 AU AU2006224529A patent/AU2006224529B2/en not_active Ceased
- 2006-03-17 ZA ZA200707413A patent/ZA200707413B/xx unknown
- 2006-03-17 RU RU2007138265/15A patent/RU2414239C2/ru not_active IP Right Cessation
- 2006-03-17 CA CA2599218A patent/CA2599218C/en not_active Expired - Fee Related
- 2006-03-17 MX MX2007011160A patent/MX2007011160A/es active IP Right Grant
- 2006-03-17 PL PL06725140T patent/PL1868642T3/pl unknown
- 2006-03-17 EP EP06725140.5A patent/EP1868642B1/en not_active Not-in-force
- 2006-03-17 CN CN2006800088726A patent/CN101141979B/zh not_active Expired - Fee Related
- 2006-03-17 PT PT67251405T patent/PT1868642E/pt unknown
- 2006-03-17 US US11/886,577 patent/US7767212B2/en not_active Expired - Fee Related
- 2006-03-17 BR BRPI0608455-9A patent/BRPI0608455A2/pt active Search and Examination
- 2006-03-17 DK DK06725140.5T patent/DK1868642T3/da active
- 2006-03-17 WO PCT/EP2006/060845 patent/WO2006097530A2/en not_active Ceased
- 2006-03-17 CN CN2013101152149A patent/CN103203016A/zh active Pending
- 2006-03-17 JP JP2008501331A patent/JP5302671B2/ja not_active Expired - Fee Related
-
2007
- 2007-08-07 IL IL185103A patent/IL185103A0/en not_active IP Right Cessation
-
2010
- 2010-05-21 US US12/785,174 patent/US20110045013A1/en not_active Abandoned
-
2012
- 2012-12-21 US US13/724,331 patent/US20130344098A1/en not_active Abandoned
-
2013
- 2013-03-12 JP JP2013048847A patent/JP2013155176A/ja active Pending
- 2013-07-26 CY CY20131100638T patent/CY1114171T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007138265A (ru) | 2009-04-27 |
| EP1868642A2 (en) | 2007-12-26 |
| NZ561040A (en) | 2009-04-30 |
| CA2599218C (en) | 2015-08-11 |
| JP2008535800A (ja) | 2008-09-04 |
| BRPI0608455A2 (pt) | 2010-01-05 |
| PL1868642T3 (pl) | 2013-10-31 |
| ES2424229T3 (es) | 2013-09-30 |
| CA2599218A1 (en) | 2006-09-21 |
| CN103203016A (zh) | 2013-07-17 |
| CN101141979B (zh) | 2013-05-08 |
| JP2013155176A (ja) | 2013-08-15 |
| US20110045013A1 (en) | 2011-02-24 |
| US7767212B2 (en) | 2010-08-03 |
| AU2006224529B2 (en) | 2012-05-24 |
| US20090175896A1 (en) | 2009-07-09 |
| ZA200707413B (en) | 2009-01-28 |
| AU2006224529A1 (en) | 2006-09-21 |
| JP5302671B2 (ja) | 2013-10-02 |
| IL185103A0 (en) | 2007-12-03 |
| KR20070112225A (ko) | 2007-11-22 |
| EP1868642B1 (en) | 2013-05-08 |
| DK1868642T3 (da) | 2013-06-24 |
| WO2006097530A3 (en) | 2007-06-21 |
| MX2007011160A (es) | 2007-11-13 |
| WO2006097530A2 (en) | 2006-09-21 |
| RU2414239C2 (ru) | 2011-03-20 |
| US20130344098A1 (en) | 2013-12-26 |
| PT1868642E (pt) | 2013-07-10 |
| CN101141979A (zh) | 2008-03-12 |
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