DE60136653D1 - Mutante allergene - Google Patents

Mutante allergene

Info

Publication number
DE60136653D1
DE60136653D1 DE60136653T DE60136653T DE60136653D1 DE 60136653 D1 DE60136653 D1 DE 60136653D1 DE 60136653 T DE60136653 T DE 60136653T DE 60136653 T DE60136653 T DE 60136653T DE 60136653 D1 DE60136653 D1 DE 60136653D1
Authority
DE
Germany
Prior art keywords
allergens
allergene
mutante
disclosed
naturally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136653T
Other languages
English (en)
Inventor
Jens Holm
Henrik Ipsen
Larsen Joergen Nedergaard
Michael Dho Spangfort
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALK Abello AS
Original Assignee
ALK Abello AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27222455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60136653(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ALK Abello AS filed Critical ALK Abello AS
Application granted granted Critical
Publication of DE60136653D1 publication Critical patent/DE60136653D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43568—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from wasps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Insects & Arthropods (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60136653T 2000-11-16 2001-11-16 Mutante allergene Expired - Lifetime DE60136653D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24936100P 2000-11-16 2000-11-16
DKPA200001718 2000-11-16
US29817001P 2001-06-14 2001-06-14
PCT/DK2001/000764 WO2002040676A2 (en) 2000-11-16 2001-11-16 Mutant allergens

Publications (1)

Publication Number Publication Date
DE60136653D1 true DE60136653D1 (de) 2009-01-02

Family

ID=27222455

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60136653T Expired - Lifetime DE60136653D1 (de) 2000-11-16 2001-11-16 Mutante allergene

Country Status (18)

Country Link
EP (1) EP1373510B1 (de)
JP (1) JP2004521618A (de)
KR (1) KR100919914B1 (de)
CN (1) CN100577804C (de)
AT (1) ATE414773T1 (de)
AU (2) AU2002223505B2 (de)
CA (1) CA2429172C (de)
CZ (1) CZ20031653A3 (de)
DE (1) DE60136653D1 (de)
DK (1) DK1373510T3 (de)
ES (1) ES2317955T3 (de)
HK (1) HK1060371A1 (de)
HU (1) HUP0302601A3 (de)
MX (1) MXPA03004174A (de)
NO (1) NO329721B1 (de)
NZ (1) NZ525820A (de)
PL (1) PL214225B1 (de)
WO (1) WO2002040676A2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020051794A1 (en) 2000-08-09 2002-05-02 Alk-Abello A/S Novel parenteral vaccine formulations and uses thereof
PL212139B1 (pl) * 2002-05-16 2012-08-31 Alk Abello As Zrekombinowany alergen, zastosowanie zrekombinowanego alergenu, kompozycja zawierająca dwa lub więcej wariantów zrekombinowanych zmutowanych alergenów, zastosowanie takiej kompozycji, kompozycja farmaceutyczna zawierająca zrekombinowany alergen lub wymienioną kompozycję, zastosowanie zrekombinowanego alergenu, kompozycji lub kompozycji farmaceutycznej, sposób przygotowania kompozycji farmaceutycznej, sposób przygotowania zrekombinowanego alergenu, sposób przygotowania biblioteki zrekombinowanego alergenu, sekwencja DNA kodująca zrekombinowany alergen, wektor ekspresyjny obejmujący wymienione DNA, komórka gospodarza zawierająca taki wektor ekspresyjny, sposób produkcji zrekombinowanego mutanta alergenu, oraz oznaczenie diagnostyczne do oceny odpowiedniości, bezpieczeństwa lub wyniku terapii
FR2841906B1 (fr) * 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
CN1714153A (zh) 2002-11-01 2005-12-28 阿尔克-阿贝洛有限公司 重组蛋白质变异体
WO2004047793A1 (en) 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
US8012505B2 (en) 2003-02-28 2011-09-06 Alk-Abello A/S Dosage form having a saccharide matrix
CA2516291C (en) 2003-02-28 2012-02-14 Alk-Abello A/S Dosage form having a saccharide matrix
WO2004108758A1 (de) * 2003-06-04 2004-12-16 Merck Patent Gmbh Phl p 5a-derivate mit reduzierter allergenität und erhaltener t-zellreaktivität
RU2006126051A (ru) 2003-12-19 2008-01-27 Альк-Абелло А/С (Dk) Способы получения партии активного фармацевтического ингредиента, контейнер, содержащий криогранулы аллергенного продукта, и криогранула аллергенного продукта
CN1894026B (zh) * 2003-12-19 2012-01-25 阿尔克-阿贝洛有限公司 用于活性药剂的低温制粒和贮藏的方法
US20070225207A1 (en) * 2004-04-23 2007-09-27 Novozymes A/S Group 1 Mite Polypeptide Variants
US20060115499A1 (en) * 2004-09-27 2006-06-01 Alk-Abello A/S Liquid allergy vaccine formulation for oromucosal administration
WO2006042558A2 (en) * 2004-10-22 2006-04-27 Novozymes A/S Group 2 mite polypeptide variants
AU2006224529B2 (en) 2005-03-18 2012-05-24 Cytos Biotechnology Ag Cat allergen fusion proteins and uses thereof
AU2006299310A1 (en) 2005-10-04 2007-04-12 Alk-Abello A/S Solid vaccine formulation
AU2006310881B2 (en) * 2005-11-04 2012-07-19 Alk-Abello A/S Use of a liquid allergy vaccine formulation for oromucosal administration
BRPI0618241A2 (pt) * 2005-11-04 2011-08-23 Alk Abello As uso de um alérgeno para fabricação de uma formulação de vacina lìquida para prevenção ou tratamento de alergia
ITMI20052517A1 (it) 2005-12-29 2007-06-30 Lofarma Spa Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa
AT503297B1 (de) * 2006-05-18 2007-09-15 Biomay Ag Allergen-spezifische antikörper
AT503690A1 (de) 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
EP1908777B1 (de) * 2006-10-06 2016-02-03 Stallergenes Milbenfusionsproteine
EP1974746B1 (de) 2007-03-28 2012-01-11 Alk-Abelló A/S Verwendung einer hilfsstoffhaltigen Impfstoffformulierung für parenterale Verabreichung
KR101699554B1 (ko) * 2007-08-15 2017-01-25 서카시아 리미티드 백신용 펩티드
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
EP2442828B1 (de) 2009-06-19 2016-08-03 Alk-Abelló S.A. Neuartige weise zur verabreichung von allergen bei einer allergenspezifischen immuntherapie
CN105061571A (zh) * 2010-01-14 2015-11-18 默克专利股份公司 因脯氨酸残基突变而具有降低变应原性的真禾本科第5组变应原的变体
EP2388268A1 (de) * 2010-05-18 2011-11-23 Stallergenes S.A. Rekombinantes, in Pichia pastoris als natürliches Allergen exprimiertes Der-p-2 zur Immuntherapie und für Diagnosezwecke
FI20115375A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
FI20115374A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
ITMI20112301A1 (it) 2011-12-19 2013-06-20 Lofarma Spa Varianti ipoallergeniche dell'allergene maggiore phl p 5 di phleum pratense
EP2692732A1 (de) 2012-08-03 2014-02-05 Stallergenes S.A. Neues Allergen aus Kreuzkrautpollen und Verwendung davon
CN110075285A (zh) 2012-10-30 2019-08-02 阿拉沃克斯有限公司 新颖的免疫治疗分子和其用途
CA2914037A1 (en) * 2013-06-06 2014-12-11 Anergis S.A. Contiguous overlapping peptides for treatment of house dust mites allergy
EP3050040A2 (de) 2013-09-24 2016-08-03 Fibar Group S.A. Intelligenter rauchmelder
BR112016006813A2 (pt) 2013-09-25 2017-09-19 Aravax Pty Ltd Composição imunoterapêutica nova e seus usos
EP2952200A1 (de) 2014-06-04 2015-12-09 Alk-Abelló A/S Allergen zur vorbeugenden Behandlung von Allergien
US9898175B2 (en) 2014-08-05 2018-02-20 Fibar Group S.A. Home network manager for home automation
EP3269730A1 (de) * 2016-07-12 2018-01-17 Universität Salzburg Allergenvarianten
EP3625332B1 (de) * 2017-05-19 2022-02-02 F. Hoffmann-La Roche AG Verfahren zur herstellung von thymocytüberstand
CN110093336B (zh) * 2018-01-29 2023-03-24 上海雅心生物技术有限公司 一种稳定的胰蛋白酶及其制备方法
RU2761431C9 (ru) 2020-10-26 2022-04-18 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) Рекомбинантный полипептид на основе аллергена пыльцы березы и аллергена яблока в качестве вакцины от аллергии
WO2023242436A1 (en) * 2022-06-17 2023-12-21 Danmarks Tekniske Universitet Allergy vaccines based on consensus allergens

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030150A2 (en) * 1996-02-15 1997-08-21 Pangenetics B.V. Molecules for the induction of immunological tolerance
DE19713001A1 (de) * 1997-03-27 1998-10-01 Merck Patent Gmbh Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung
AU743647B2 (en) * 1998-01-31 2002-01-31 Mt. Sinai School Of Medicine Of New York University Methods and reagents for decreasing allergic reactions
DE69939584D1 (de) * 1998-03-16 2008-10-30 Alk Abello As Mutiertes rekombinantes allergen

Also Published As

Publication number Publication date
CN100577804C (zh) 2010-01-06
EP1373510A2 (de) 2004-01-02
CA2429172C (en) 2012-03-20
CN1484699A (zh) 2004-03-24
KR100919914B1 (ko) 2009-10-06
EP1373510B1 (de) 2008-11-19
CA2429172A1 (en) 2002-05-23
NO20032213L (no) 2003-07-02
JP2004521618A (ja) 2004-07-22
NZ525820A (en) 2005-01-28
PL214225B1 (pl) 2013-07-31
HK1060371A1 (en) 2004-08-06
ATE414773T1 (de) 2008-12-15
HUP0302601A3 (en) 2010-01-28
HUP0302601A2 (hu) 2003-11-28
NO20032213D0 (no) 2003-05-15
AU2350502A (en) 2002-05-27
ES2317955T3 (es) 2009-05-01
WO2002040676A3 (en) 2003-10-09
DK1373510T3 (da) 2009-02-23
NO329721B1 (no) 2010-12-06
KR20030076577A (ko) 2003-09-26
MXPA03004174A (es) 2004-12-02
WO2002040676A2 (en) 2002-05-23
PL362273A1 (en) 2004-10-18
AU2002223505B2 (en) 2006-12-07
CZ20031653A3 (en) 2004-03-17

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