TNSN97130A1 - Variants de l'aprotinine presentant des proprietes ameliorees - Google Patents

Variants de l'aprotinine presentant des proprietes ameliorees

Info

Publication number
TNSN97130A1
TNSN97130A1 TNTNSN97130A TNSN97130A TNSN97130A1 TN SN97130 A1 TNSN97130 A1 TN SN97130A1 TN TNSN97130 A TNTNSN97130 A TN TNSN97130A TN SN97130 A TNSN97130 A TN SN97130A TN SN97130 A1 TNSN97130 A1 TN SN97130A1
Authority
TN
Tunisia
Prior art keywords
improved properties
aprotinin variants
variants
aprotinin
properties
Prior art date
Application number
TNTNSN97130A
Other languages
English (en)
Inventor
Werner Schroder Dr
Bjorn Soren
Norris Kjeld
Diness Viggo
Norkskov Leif
Dyhr Christensen Niels
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of TNSN97130A1 publication Critical patent/TNSN97130A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE DES VARIANTS DE L'APROTININE PRESENTANT DES PROPRIETES IMMUNOLOGIQUES ET PHARMACOCINETIQUES AMELIOREES, AINSI QUE DE MEILLEURES PROPRIETES INHIBITRICES D'ENZYMES, ET LEUR PREPARATION
TNTNSN97130A 1996-07-25 1997-07-24 Variants de l'aprotinine presentant des proprietes ameliorees TNSN97130A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19629982A DE19629982A1 (de) 1996-07-25 1996-07-25 Aprotinin-Varianten mit verbesserten Eigenschaften

Publications (1)

Publication Number Publication Date
TNSN97130A1 true TNSN97130A1 (fr) 2005-03-15

Family

ID=7800774

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN97130A TNSN97130A1 (fr) 1996-07-25 1997-07-24 Variants de l'aprotinine presentant des proprietes ameliorees

Country Status (37)

Country Link
US (2) US6482798B2 (fr)
EP (1) EP0821007B1 (fr)
JP (1) JPH10101700A (fr)
KR (1) KR980009283A (fr)
CN (1) CN1172116A (fr)
AR (1) AR008783A1 (fr)
AT (1) ATE260975T1 (fr)
AU (2) AU2870197A (fr)
BG (1) BG101787A (fr)
BR (1) BR9704068A (fr)
CA (1) CA2207071A1 (fr)
CO (1) CO4890857A1 (fr)
CZ (1) CZ236797A3 (fr)
DE (2) DE19629982A1 (fr)
DZ (1) DZ2276A1 (fr)
EE (1) EE9700177A (fr)
ES (1) ES2217350T3 (fr)
HN (1) HN1997000094A (fr)
HR (1) HRP970384A2 (fr)
HU (1) HUP9701290A3 (fr)
ID (1) ID17508A (fr)
IL (1) IL121361A0 (fr)
MA (1) MA24279A1 (fr)
NO (1) NO973426L (fr)
NZ (1) NZ328402A (fr)
PE (1) PE92298A1 (fr)
PL (1) PL321341A1 (fr)
RU (1) RU2197983C2 (fr)
SG (1) SG71714A1 (fr)
SK (1) SK101997A3 (fr)
SV (1) SV1997000068A (fr)
TN (1) TNSN97130A1 (fr)
TR (1) TR199700688A2 (fr)
TW (1) TW480271B (fr)
UA (1) UA55380C2 (fr)
YU (1) YU31697A (fr)
ZA (1) ZA976585B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6974188B2 (en) * 2003-08-13 2005-12-13 Cosco Management, Inc. Chair with pivotable chair back
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
WO2006042327A2 (fr) * 2004-10-12 2006-04-20 Large Scale Biology Corporation Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine
PL2360258T3 (pl) * 2005-02-18 2015-03-31 Angiochem Inc Polipeptydy aprotyniny do transportowania związków przez barierę krew-mózg
WO2008077478A1 (fr) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Préparation et utilisation de variants du domaine 2 de kunitz du gène de la bikunine placentaire humaine
WO2008110301A1 (fr) * 2007-03-13 2008-09-18 Bayer Schering Pharma Aktiengesellschaft Variants d'aprotinine à propriétés améliorées
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
BRPI1103921A2 (pt) 2011-08-17 2013-08-06 Mahle Metal Leve Sa camisa de cilindro e liga de ferro fundido

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
US4595974A (en) * 1984-09-10 1986-06-17 Burroughs Corporation Base drive circuit for a switching power transistor
GB2208511A (en) 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
US5591603A (en) 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5231010A (en) 1989-09-13 1993-07-27 Bayer Aktiengesellschaft Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
US5747449A (en) * 1992-07-13 1998-05-05 Corvas International, Inc. Bovine pancreatic trypsin inhibitor derived inhibitors of factor XA
KR100199565B1 (ko) * 1994-08-19 1999-06-15 차동천 승화형 감열전사 기록용 수용지의 중간층 제조방법

Also Published As

Publication number Publication date
EE9700177A (et) 1998-02-16
JPH10101700A (ja) 1998-04-21
CA2207071A1 (fr) 1998-01-25
ATE260975T1 (de) 2004-03-15
CO4890857A1 (es) 2000-02-28
EP0821007A3 (fr) 1998-11-18
DE19629982A1 (de) 1998-01-29
YU31697A (sh) 1999-07-28
IL121361A0 (en) 1998-01-04
HN1997000094A (es) 1997-12-26
CZ236797A3 (cs) 1998-02-18
NZ328402A (en) 1999-03-29
HRP970384A2 (en) 1998-04-30
ID17508A (id) 1998-01-08
TR199700688A2 (xx) 1998-02-21
BR9704068A (pt) 1999-01-05
NO973426D0 (no) 1997-07-24
AU5178701A (en) 2001-09-06
DE59711356D1 (de) 2004-04-08
EP0821007A2 (fr) 1998-01-28
SG71714A1 (en) 2000-04-18
RU2197983C2 (ru) 2003-02-10
AU762041B2 (en) 2003-06-19
MX9705605A (es) 1998-08-30
SV1997000068A (es) 1998-07-09
HUP9701290A3 (en) 2000-08-28
HU9701290D0 (en) 1997-09-29
BG101787A (en) 1998-10-30
HUP9701290A2 (hu) 1999-06-28
SK101997A3 (en) 1998-03-04
PE92298A1 (es) 1999-02-13
ES2217350T3 (es) 2004-11-01
UA55380C2 (uk) 2003-04-15
ZA976585B (en) 1998-02-03
PL321341A1 (en) 1998-02-02
KR980009283A (ko) 1998-04-30
AU2870197A (en) 1998-02-05
TW480271B (en) 2002-03-21
US20030096752A1 (en) 2003-05-22
NO973426L (no) 1998-01-26
MA24279A1 (fr) 1998-04-01
EP0821007B1 (fr) 2004-03-03
AR008783A1 (es) 2000-02-23
US20020103334A1 (en) 2002-08-01
DZ2276A1 (fr) 2002-12-18
US6482798B2 (en) 2002-11-19
CN1172116A (zh) 1998-02-04

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