SK101997A3 - Aprotinin variants with improved properties, drugs containing the same and their use - Google Patents

Aprotinin variants with improved properties, drugs containing the same and their use Download PDF

Info

Publication number
SK101997A3
SK101997A3 SK1019-97A SK101997A SK101997A3 SK 101997 A3 SK101997 A3 SK 101997A3 SK 101997 A SK101997 A SK 101997A SK 101997 A3 SK101997 A3 SK 101997A3
Authority
SK
Slovakia
Prior art keywords
aprotinin
arg15
thr26
asn41
ser10
Prior art date
Application number
SK1019-97A
Other languages
English (en)
Slovak (sk)
Inventor
Werner Schroder
Soren Bjorn
Kjeld Norris
Viggo Diness
Leif Norkskov-Lauritsen
Niels D Christensen
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SK101997A3 publication Critical patent/SK101997A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SK1019-97A 1996-07-25 1997-07-24 Aprotinin variants with improved properties, drugs containing the same and their use SK101997A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19629982A DE19629982A1 (de) 1996-07-25 1996-07-25 Aprotinin-Varianten mit verbesserten Eigenschaften

Publications (1)

Publication Number Publication Date
SK101997A3 true SK101997A3 (en) 1998-03-04

Family

ID=7800774

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1019-97A SK101997A3 (en) 1996-07-25 1997-07-24 Aprotinin variants with improved properties, drugs containing the same and their use

Country Status (37)

Country Link
US (2) US6482798B2 (fr)
EP (1) EP0821007B1 (fr)
JP (1) JPH10101700A (fr)
KR (1) KR980009283A (fr)
CN (1) CN1172116A (fr)
AR (1) AR008783A1 (fr)
AT (1) ATE260975T1 (fr)
AU (2) AU2870197A (fr)
BG (1) BG101787A (fr)
BR (1) BR9704068A (fr)
CA (1) CA2207071A1 (fr)
CO (1) CO4890857A1 (fr)
CZ (1) CZ236797A3 (fr)
DE (2) DE19629982A1 (fr)
DZ (1) DZ2276A1 (fr)
EE (1) EE9700177A (fr)
ES (1) ES2217350T3 (fr)
HN (1) HN1997000094A (fr)
HR (1) HRP970384A2 (fr)
HU (1) HUP9701290A3 (fr)
ID (1) ID17508A (fr)
IL (1) IL121361A0 (fr)
MA (1) MA24279A1 (fr)
NO (1) NO973426L (fr)
NZ (1) NZ328402A (fr)
PE (1) PE92298A1 (fr)
PL (1) PL321341A1 (fr)
RU (1) RU2197983C2 (fr)
SG (1) SG71714A1 (fr)
SK (1) SK101997A3 (fr)
SV (1) SV1997000068A (fr)
TN (1) TNSN97130A1 (fr)
TR (1) TR199700688A2 (fr)
TW (1) TW480271B (fr)
UA (1) UA55380C2 (fr)
YU (1) YU31697A (fr)
ZA (1) ZA976585B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6974188B2 (en) * 2003-08-13 2005-12-13 Cosco Management, Inc. Chair with pivotable chair back
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
WO2006042327A2 (fr) * 2004-10-12 2006-04-20 Large Scale Biology Corporation Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine
PL2360258T3 (pl) * 2005-02-18 2015-03-31 Angiochem Inc Polipeptydy aprotyniny do transportowania związków przez barierę krew-mózg
WO2008077478A1 (fr) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Préparation et utilisation de variants du domaine 2 de kunitz du gène de la bikunine placentaire humaine
WO2008110301A1 (fr) * 2007-03-13 2008-09-18 Bayer Schering Pharma Aktiengesellschaft Variants d'aprotinine à propriétés améliorées
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
BRPI1103921A2 (pt) 2011-08-17 2013-08-06 Mahle Metal Leve Sa camisa de cilindro e liga de ferro fundido

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
US4595974A (en) * 1984-09-10 1986-06-17 Burroughs Corporation Base drive circuit for a switching power transistor
GB2208511A (en) 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
US5591603A (en) 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5231010A (en) 1989-09-13 1993-07-27 Bayer Aktiengesellschaft Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
US5747449A (en) * 1992-07-13 1998-05-05 Corvas International, Inc. Bovine pancreatic trypsin inhibitor derived inhibitors of factor XA
KR100199565B1 (ko) * 1994-08-19 1999-06-15 차동천 승화형 감열전사 기록용 수용지의 중간층 제조방법

Also Published As

Publication number Publication date
TNSN97130A1 (fr) 2005-03-15
EE9700177A (et) 1998-02-16
JPH10101700A (ja) 1998-04-21
CA2207071A1 (fr) 1998-01-25
ATE260975T1 (de) 2004-03-15
CO4890857A1 (es) 2000-02-28
EP0821007A3 (fr) 1998-11-18
DE19629982A1 (de) 1998-01-29
YU31697A (sh) 1999-07-28
IL121361A0 (en) 1998-01-04
HN1997000094A (es) 1997-12-26
CZ236797A3 (cs) 1998-02-18
NZ328402A (en) 1999-03-29
HRP970384A2 (en) 1998-04-30
ID17508A (id) 1998-01-08
TR199700688A2 (xx) 1998-02-21
BR9704068A (pt) 1999-01-05
NO973426D0 (no) 1997-07-24
AU5178701A (en) 2001-09-06
DE59711356D1 (de) 2004-04-08
EP0821007A2 (fr) 1998-01-28
SG71714A1 (en) 2000-04-18
RU2197983C2 (ru) 2003-02-10
AU762041B2 (en) 2003-06-19
MX9705605A (es) 1998-08-30
SV1997000068A (es) 1998-07-09
HUP9701290A3 (en) 2000-08-28
HU9701290D0 (en) 1997-09-29
BG101787A (en) 1998-10-30
HUP9701290A2 (hu) 1999-06-28
PE92298A1 (es) 1999-02-13
ES2217350T3 (es) 2004-11-01
UA55380C2 (uk) 2003-04-15
ZA976585B (en) 1998-02-03
PL321341A1 (en) 1998-02-02
KR980009283A (ko) 1998-04-30
AU2870197A (en) 1998-02-05
TW480271B (en) 2002-03-21
US20030096752A1 (en) 2003-05-22
NO973426L (no) 1998-01-26
MA24279A1 (fr) 1998-04-01
EP0821007B1 (fr) 2004-03-03
AR008783A1 (es) 2000-02-23
US20020103334A1 (en) 2002-08-01
DZ2276A1 (fr) 2002-12-18
US6482798B2 (en) 2002-11-19
CN1172116A (zh) 1998-02-04

Similar Documents

Publication Publication Date Title
FI94876C (fi) Menetelmä aprotiniinin valmistamiseksi yhdistelmä-DNA-tekniikalla ja menetelmään soveltuva DNA, ilmentämisplasmidi ja isäntäsolu
KR20020008131A (ko) 혈소판 부착 차단용 단백질
US5332804A (en) High molecular weight human angiogenic basic fibroblast growth factors
NZ246567A (en) Variant polypeptides of a human kunitz type protease inhibitor domain and pharmaceutical compositions thereof
EP0740702A1 (fr) Nouvel homologue de precurseur de proteine amyloide humaine et nouveaux inhibiteurs de type kunitz
WO1992007935A1 (fr) Proteines de fusion ciblees par clycosaminoglycane, leurs conception, construction et compositions
IL171158A (en) Cliquin inhibitors
SK101997A3 (en) Aprotinin variants with improved properties, drugs containing the same and their use
US5945275A (en) Nematode-extracted anticoagulant protein
JP2916228B2 (ja) 遺伝子操作した組み換えアプロチニン変異型、均質に処理されたアプロチニン変異型の微生物調製の方法およびその治療学的使用
AU705267B2 (en) Process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence
JP2002503958A (ja) 改良された特性をもつアプロチニン変異体およびアプロチニン変異体のビクニン
WO2007101602A9 (fr) Domaines kunitz chimeriques et utilisation associee
US5188943A (en) Method of producing high molecular weight human fibroblast growth factors
US5231010A (en) Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
NZ219608A (en) Minactivin (urokinase-type plasminogen activator inhibitor) peptides, dna coding it and its production via recombinant dna methods
MXPA97005605A (es) Variantes de aprotinina con propiedades mejoradas
WO2008077478A1 (fr) Préparation et utilisation de variants du domaine 2 de kunitz du gène de la bikunine placentaire humaine