AR008783A1 - Variantes de aprotinina con propiedades mejoradas - Google Patents

Variantes de aprotinina con propiedades mejoradas

Info

Publication number
AR008783A1
AR008783A1 ARP970103329A ARP970103329A AR008783A1 AR 008783 A1 AR008783 A1 AR 008783A1 AR P970103329 A ARP970103329 A AR P970103329A AR P970103329 A ARP970103329 A AR P970103329A AR 008783 A1 AR008783 A1 AR 008783A1
Authority
AR
Argentina
Prior art keywords
improved properties
aprotinin variants
aprotinin
variants
pharmacokinetic
Prior art date
Application number
ARP970103329A
Other languages
English (en)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of AR008783A1 publication Critical patent/AR008783A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invencion se refiere a variantes de aprotinina con propiedades inhibitorias de enzimas, inmunologicas y farmacocinéticas mejoradas y a suproduccion.
ARP970103329A 1996-07-25 1997-07-23 Variantes de aprotinina con propiedades mejoradas AR008783A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19629982A DE19629982A1 (de) 1996-07-25 1996-07-25 Aprotinin-Varianten mit verbesserten Eigenschaften

Publications (1)

Publication Number Publication Date
AR008783A1 true AR008783A1 (es) 2000-02-23

Family

ID=7800774

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103329A AR008783A1 (es) 1996-07-25 1997-07-23 Variantes de aprotinina con propiedades mejoradas

Country Status (37)

Country Link
US (2) US6482798B2 (es)
EP (1) EP0821007B1 (es)
JP (1) JPH10101700A (es)
KR (1) KR980009283A (es)
CN (1) CN1172116A (es)
AR (1) AR008783A1 (es)
AT (1) ATE260975T1 (es)
AU (2) AU2870197A (es)
BG (1) BG101787A (es)
BR (1) BR9704068A (es)
CA (1) CA2207071A1 (es)
CO (1) CO4890857A1 (es)
CZ (1) CZ236797A3 (es)
DE (2) DE19629982A1 (es)
DZ (1) DZ2276A1 (es)
EE (1) EE9700177A (es)
ES (1) ES2217350T3 (es)
HN (1) HN1997000094A (es)
HR (1) HRP970384A2 (es)
HU (1) HUP9701290A3 (es)
ID (1) ID17508A (es)
IL (1) IL121361A0 (es)
MA (1) MA24279A1 (es)
NO (1) NO973426L (es)
NZ (1) NZ328402A (es)
PE (1) PE92298A1 (es)
PL (1) PL321341A1 (es)
RU (1) RU2197983C2 (es)
SG (1) SG71714A1 (es)
SK (1) SK101997A3 (es)
SV (1) SV1997000068A (es)
TN (1) TNSN97130A1 (es)
TR (1) TR199700688A2 (es)
TW (1) TW480271B (es)
UA (1) UA55380C2 (es)
YU (1) YU31697A (es)
ZA (1) ZA976585B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6974188B2 (en) * 2003-08-13 2005-12-13 Cosco Management, Inc. Chair with pivotable chair back
WO2006042327A2 (en) * 2004-10-12 2006-04-20 Large Scale Biology Corporation Plant-produced recombinant aprotinin and aprotinin variants
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
ES2383901T5 (es) * 2005-02-18 2015-02-25 Angiochem Inc. Polipéptidos de aprotinina para transportar un compuesto a través de la barrera sangre-cerebro
WO2008077478A1 (en) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
WO2008110301A1 (de) * 2007-03-13 2008-09-18 Bayer Schering Pharma Aktiengesellschaft Aprotinin-varianten mit verbesserten eigenschaften
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
BRPI1103921A2 (pt) 2011-08-17 2013-08-06 Mahle Metal Leve Sa camisa de cilindro e liga de ferro fundido

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
US4595974A (en) * 1984-09-10 1986-06-17 Burroughs Corporation Base drive circuit for a switching power transistor
GB2208511A (en) 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
US5591603A (en) 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DE3930522A1 (de) 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5231010A (en) 1989-09-13 1993-07-27 Bayer Aktiengesellschaft Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
EP0651766A4 (en) * 1992-07-13 1996-07-31 Corvas Int Inc INHIBITORS OF FACTOR Xa, DERIVED FROM THE INHIBITOR OF THE PANCREATIC TRYPSON FROM BEEF.
KR100199565B1 (ko) * 1994-08-19 1999-06-15 차동천 승화형 감열전사 기록용 수용지의 중간층 제조방법

Also Published As

Publication number Publication date
DE19629982A1 (de) 1998-01-29
NZ328402A (en) 1999-03-29
CN1172116A (zh) 1998-02-04
SK101997A3 (en) 1998-03-04
NO973426L (no) 1998-01-26
TW480271B (en) 2002-03-21
AU762041B2 (en) 2003-06-19
SG71714A1 (en) 2000-04-18
US6482798B2 (en) 2002-11-19
HRP970384A2 (en) 1998-04-30
HUP9701290A3 (en) 2000-08-28
EE9700177A (et) 1998-02-16
US20020103334A1 (en) 2002-08-01
PE92298A1 (es) 1999-02-13
EP0821007A2 (de) 1998-01-28
SV1997000068A (es) 1998-07-09
CA2207071A1 (en) 1998-01-25
KR980009283A (ko) 1998-04-30
HU9701290D0 (en) 1997-09-29
CZ236797A3 (cs) 1998-02-18
ID17508A (id) 1998-01-08
YU31697A (sh) 1999-07-28
DZ2276A1 (fr) 2002-12-18
BR9704068A (pt) 1999-01-05
ATE260975T1 (de) 2004-03-15
JPH10101700A (ja) 1998-04-21
ZA976585B (en) 1998-02-03
NO973426D0 (no) 1997-07-24
CO4890857A1 (es) 2000-02-28
MX9705605A (es) 1998-08-30
BG101787A (en) 1998-10-30
EP0821007A3 (de) 1998-11-18
AU5178701A (en) 2001-09-06
UA55380C2 (uk) 2003-04-15
US20030096752A1 (en) 2003-05-22
TR199700688A2 (xx) 1998-02-21
RU2197983C2 (ru) 2003-02-10
PL321341A1 (en) 1998-02-02
HUP9701290A2 (hu) 1999-06-28
IL121361A0 (en) 1998-01-04
HN1997000094A (es) 1997-12-26
MA24279A1 (fr) 1998-04-01
TNSN97130A1 (fr) 2005-03-15
EP0821007B1 (de) 2004-03-03
ES2217350T3 (es) 2004-11-01
AU2870197A (en) 1998-02-05
DE59711356D1 (de) 2004-04-08

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal