HUP0302601A2 - Mutáns allergének - Google Patents

Mutáns allergének

Info

Publication number
HUP0302601A2
HUP0302601A2 HU0302601A HUP0302601A HUP0302601A2 HU P0302601 A2 HUP0302601 A2 HU P0302601A2 HU 0302601 A HU0302601 A HU 0302601A HU P0302601 A HUP0302601 A HU P0302601A HU P0302601 A2 HUP0302601 A2 HU P0302601A2
Authority
HU
Hungary
Prior art keywords
allergens
subject
naturally occurring
recombinant
mutant allergens
Prior art date
Application number
HU0302601A
Other languages
English (en)
Inventor
Jens Holm
Henrik Ipsen
Jorgen Nedergaard Larsen
Michael Dho Spangfort
Original Assignee
Alk-Abelló A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27222455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0302601(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alk-Abelló A/S filed Critical Alk-Abelló A/S
Publication of HUP0302601A2 publication Critical patent/HUP0302601A2/hu
Publication of HUP0302601A3 publication Critical patent/HUP0302601A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43568—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from wasps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Insects & Arthropods (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A találmány tárgyát több mutációt tartalmazó, csökkent IgE-kötőaffinitású rekombináns allergének képezik. Az allergének természetbenelőforduló allergének természetben nem előforduló mutánsai. Azáltalános a-szén gerinc harmadlagos szerkezetük lényegében megmaradt.A találmány tárgyát képezi eljárás ilyen rekombináns allergénekelőállítására, valamint azok alkalmazásai is. Ó
HU0302601A 2000-11-16 2001-11-16 Mutant allergens HUP0302601A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24936100P 2000-11-16 2000-11-16
DKPA200001718 2000-11-16
US29817001P 2001-06-14 2001-06-14
PCT/DK2001/000764 WO2002040676A2 (en) 2000-11-16 2001-11-16 Mutant allergens

Publications (2)

Publication Number Publication Date
HUP0302601A2 true HUP0302601A2 (hu) 2003-11-28
HUP0302601A3 HUP0302601A3 (en) 2010-01-28

Family

ID=27222455

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302601A HUP0302601A3 (en) 2000-11-16 2001-11-16 Mutant allergens

Country Status (18)

Country Link
EP (1) EP1373510B1 (hu)
JP (1) JP2004521618A (hu)
KR (1) KR100919914B1 (hu)
CN (1) CN100577804C (hu)
AT (1) ATE414773T1 (hu)
AU (2) AU2350502A (hu)
CA (1) CA2429172C (hu)
CZ (1) CZ20031653A3 (hu)
DE (1) DE60136653D1 (hu)
DK (1) DK1373510T3 (hu)
ES (1) ES2317955T3 (hu)
HK (1) HK1060371A1 (hu)
HU (1) HUP0302601A3 (hu)
MX (1) MXPA03004174A (hu)
NO (1) NO329721B1 (hu)
NZ (1) NZ525820A (hu)
PL (1) PL214225B1 (hu)
WO (1) WO2002040676A2 (hu)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020051794A1 (en) 2000-08-09 2002-05-02 Alk-Abello A/S Novel parenteral vaccine formulations and uses thereof
CA2486112A1 (en) * 2002-05-16 2003-11-27 Alk Abello A/S Allergen mutants
FR2841906B1 (fr) * 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
CA2503886A1 (en) * 2002-11-01 2004-05-13 Alk-Abello A/S Recombinant protein variants
MXPA05005528A (es) 2002-11-26 2006-04-05 Alk Abello As Producto farmaceutico de alergeno.
US8012505B2 (en) 2003-02-28 2011-09-06 Alk-Abello A/S Dosage form having a saccharide matrix
AU2004216559B2 (en) 2003-02-28 2010-05-27 Alk-Abello A/S Dosage form having a saccharide matrix
PT2272863E (pt) * 2003-06-04 2013-01-30 Merck Patent Gmbh Derivados de phl p 5a com alergenicidade reduzida e reatividade da célula t retida
ES2363342T3 (es) * 2003-12-19 2011-08-01 Alk-Abelló A/S Procedimiento para criogranulación y almacenamiento de alérgenos.
CA2548249C (en) 2003-12-19 2013-02-12 Alk-Abello A/S Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product
WO2005103082A2 (en) * 2004-04-23 2005-11-03 Novozymes A/S Group 1 mite polypeptide variants
US20060115499A1 (en) * 2004-09-27 2006-06-01 Alk-Abello A/S Liquid allergy vaccine formulation for oromucosal administration
WO2006042558A2 (en) * 2004-10-22 2006-04-27 Novozymes A/S Group 2 mite polypeptide variants
CN103203016A (zh) 2005-03-18 2013-07-17 赛托斯生物技术公司 猫变应原融合蛋白及其用途
RU2008117396A (ru) 2005-10-04 2009-11-10 Альк-Абелло А/С (Dk) Твердая вакцинная композиция
AU2006310881B2 (en) * 2005-11-04 2012-07-19 Alk-Abello A/S Use of a liquid allergy vaccine formulation for oromucosal administration
DK1814516T3 (da) * 2005-11-04 2013-03-25 Alk Abello As Anvendelse af en flydende allergivaccineformulering til oromucosal indgivelse
ITMI20052517A1 (it) * 2005-12-29 2007-06-30 Lofarma Spa Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa
AT503297B1 (de) * 2006-05-18 2007-09-15 Biomay Ag Allergen-spezifische antikörper
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
EP1908777B1 (en) * 2006-10-06 2016-02-03 Stallergenes Mite fusion proteins
CA2682054A1 (en) 2007-03-28 2008-10-02 Alk-Abello A/S Use of an adjuvanted allergy vaccine formulation for parenteral administration
PT2083856E (pt) * 2007-08-15 2010-12-23 Circassia Ltd Péptidos para a dessensibilização contra alergénios
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
EP2442828B1 (en) 2009-06-19 2016-08-03 Alk-Abelló S.A. Novel manner of administrating allergen in allergen specific immunotherapy
AU2010342533B2 (en) * 2010-01-14 2017-02-23 Merck Patent Gmbh Variants of the group-5 allergens of the poaceae with reduced allergenicity by mutagenesis of proline residues
EP2388268A1 (en) * 2010-05-18 2011-11-23 Stallergenes S.A. Recombinant Der p 2 expressed in Pichia pastoris as a "natural-like" allergen for immunotherapy and diagnostic purposes
FI20115374A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
FI20115375A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
ITMI20112301A1 (it) * 2011-12-19 2013-06-20 Lofarma Spa Varianti ipoallergeniche dell'allergene maggiore phl p 5 di phleum pratense
EP2692732A1 (en) 2012-08-03 2014-02-05 Stallergenes S.A. Novel allergen from ragweed pollen and uses thereof
CN110075285A (zh) 2012-10-30 2019-08-02 阿拉沃克斯有限公司 新颖的免疫治疗分子和其用途
CN105307679A (zh) * 2013-06-06 2016-02-03 阿尼尔吉斯股份公司 用于治疗室内尘螨过敏的连续重叠肽
EP3050040A2 (en) 2013-09-24 2016-08-03 Fibar Group S.A. Intelligent smoke sensor
CA2925480A1 (en) 2013-09-25 2015-04-02 Aravax Pty Ltd Novel immunotherapeutic composition and uses thereof
EP2952200A1 (en) 2014-06-04 2015-12-09 Alk-Abelló A/S Allergen for prophylactic treatment of allergy
US9898175B2 (en) 2014-08-05 2018-02-20 Fibar Group S.A. Home network manager for home automation
EP3269730A1 (en) * 2016-07-12 2018-01-17 Universität Salzburg Allergen variant
JP6978516B2 (ja) 2017-05-19 2021-12-08 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 胸腺細胞上清を産生するための方法
CN110093336B (zh) * 2018-01-29 2023-03-24 上海雅心生物技术有限公司 一种稳定的胰蛋白酶及其制备方法
RU2761431C9 (ru) 2020-10-26 2022-04-18 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) Рекомбинантный полипептид на основе аллергена пыльцы березы и аллергена яблока в качестве вакцины от аллергии
WO2023242436A1 (en) * 2022-06-17 2023-12-21 Danmarks Tekniske Universitet Allergy vaccines based on consensus allergens

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1874997A (en) * 1996-02-15 1997-09-02 Pangenetics B.V. Molecules for the induction of immunological tolerance
DE19713001A1 (de) * 1997-03-27 1998-10-01 Merck Patent Gmbh Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung
WO1999038978A1 (en) * 1998-01-31 1999-08-05 University Of Arkansas Methods and reagents for decreasing allergic reactions
AU749749B2 (en) * 1998-03-16 2002-07-04 Alk-Abello A/S Mutant recombinant allergens

Also Published As

Publication number Publication date
PL214225B1 (pl) 2013-07-31
DK1373510T3 (da) 2009-02-23
CA2429172A1 (en) 2002-05-23
HK1060371A1 (en) 2004-08-06
DE60136653D1 (de) 2009-01-02
ATE414773T1 (de) 2008-12-15
NO329721B1 (no) 2010-12-06
JP2004521618A (ja) 2004-07-22
CZ20031653A3 (en) 2004-03-17
NO20032213D0 (no) 2003-05-15
WO2002040676A2 (en) 2002-05-23
EP1373510B1 (en) 2008-11-19
CN100577804C (zh) 2010-01-06
AU2002223505B2 (en) 2006-12-07
WO2002040676A3 (en) 2003-10-09
HUP0302601A3 (en) 2010-01-28
KR20030076577A (ko) 2003-09-26
MXPA03004174A (es) 2004-12-02
ES2317955T3 (es) 2009-05-01
EP1373510A2 (en) 2004-01-02
NZ525820A (en) 2005-01-28
AU2350502A (en) 2002-05-27
NO20032213L (no) 2003-07-02
CN1484699A (zh) 2004-03-24
PL362273A1 (en) 2004-10-18
KR100919914B1 (ko) 2009-10-06
CA2429172C (en) 2012-03-20

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