ATE448793T1 - Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens - Google Patents
Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergensInfo
- Publication number
- ATE448793T1 ATE448793T1 AT02713767T AT02713767T ATE448793T1 AT E448793 T1 ATE448793 T1 AT E448793T1 AT 02713767 T AT02713767 T AT 02713767T AT 02713767 T AT02713767 T AT 02713767T AT E448793 T1 ATE448793 T1 AT E448793T1
- Authority
- AT
- Austria
- Prior art keywords
- allergen
- immunogenicity
- allergenity
- constructs
- maintaining
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43568—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from wasps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Insects & Arthropods (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27281801P | 2001-03-02 | 2001-03-02 | |
PCT/US2002/006765 WO2002070665A2 (en) | 2001-03-02 | 2002-03-04 | Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE448793T1 true ATE448793T1 (de) | 2009-12-15 |
Family
ID=23041432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02713767T ATE448793T1 (de) | 2001-03-02 | 2002-03-04 | Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens |
Country Status (9)
Country | Link |
---|---|
US (1) | US20030039660A1 (de) |
EP (1) | EP1499349B1 (de) |
JP (1) | JP2005508134A (de) |
CN (1) | CN1610556A (de) |
AT (1) | ATE448793T1 (de) |
CA (1) | CA2441476A1 (de) |
DE (1) | DE60234475D1 (de) |
DK (1) | DK1499349T3 (de) |
WO (1) | WO2002070665A2 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004039834A2 (en) * | 2002-11-01 | 2004-05-13 | Alk-Abelló A/S | Recombinant protein variants |
US20070065906A1 (en) * | 2003-03-05 | 2007-03-22 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Process for producing heterologous protein in e. coli |
EP1680446B1 (de) * | 2003-11-05 | 2007-10-31 | Pevion Biotech Ltd. | Zusammensetzungen, die von melittin abgeleitet sind und peptide enthalten, und verfahren zur potenzierung von immunreaktionen gegen target-antigene |
ES2424229T3 (es) | 2005-03-18 | 2013-09-30 | Cytos Biotechnology Ag | Proteínas de fusión de alérgenos de gato y utilización de las mismas |
EP2692732A1 (de) | 2012-08-03 | 2014-02-05 | Stallergenes S.A. | Neues Allergen aus Kreuzkrautpollen und Verwendung davon |
US10799573B2 (en) * | 2016-03-30 | 2020-10-13 | Regents Of The University Of Minnesota | Pertussis vaccines and methods of making and using |
US11492645B2 (en) * | 2018-08-29 | 2022-11-08 | Shanghaitech University | Composition and use of Cas protein inhibitors |
JP2023515120A (ja) * | 2020-02-19 | 2023-04-12 | パーフェクト・デイ・インコーポレイテッド | 低アレルギー性組換え乳タンパク質およびこれを含む組成物 |
CN113173982B (zh) * | 2021-04-14 | 2022-09-06 | 中国海洋大学 | Rap v 2蛋白相关的抗原表位肽及其应用 |
CN114685636B (zh) * | 2022-03-04 | 2024-03-01 | 首都医科大学附属北京同仁医院 | 蒿属植物花粉过敏原、应用及试剂盒 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
US5354844A (en) | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
EP0550553B1 (de) | 1990-09-25 | 2000-07-12 | Cantab Pharmaceuticals Research Limited | Bei einer transkomplementenden zellinie erzeugter defektiver virenimpfstoff |
US5593877A (en) | 1993-03-11 | 1997-01-14 | The Rockefeller University | Nucleic acid and recombinant production of vespid venom hyaluronidase |
WO1994021807A2 (en) | 1993-03-19 | 1994-09-29 | Cantab Pharmaceuticals Research Limited | Defective mutant non-retroviral virus (e.g. hsv) as vaccine |
FR2714830B1 (fr) | 1994-01-10 | 1996-03-22 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
FR2715847B1 (fr) | 1994-02-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
EP0753069A1 (de) | 1994-04-15 | 1997-01-15 | Targeted Genetics Corporation | Fusionsprotein für Gentransfer |
FR2727679B1 (fr) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
US5804201A (en) | 1996-03-11 | 1998-09-08 | The Rockefeller University | Immunomodulatory peptides of vespid antigen 5 |
US6432699B1 (en) | 1997-03-28 | 2002-08-13 | New York University | Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A |
CN1261812A (zh) | 1997-06-30 | 2000-08-02 | 罗纳-布朗克罗莱尔股份有限公司 | 用于向组织中体内进行核酸载体最佳电转移的装置 |
CN1261808A (zh) | 1997-06-30 | 2000-08-02 | 罗纳-布朗克罗莱尔股份有限公司 | 向多细胞真核生物的细胞中转移核酸的改进方法和用于实施该方法的组合 |
IL133710A0 (en) | 1997-06-30 | 2001-04-30 | Rhone Poulence Rorer S A | Improved method for transferring nucleic acid into the striped muscle and combination thereof |
DK1062341T3 (da) * | 1998-03-16 | 2008-11-03 | Alk Abello As | Muterede rekombinante allergener |
AU2631501A (en) * | 2000-01-06 | 2001-07-16 | Monsanto Technology Llc | Preparation of deallergenized proteins and permuteins |
WO2004039834A2 (en) * | 2002-11-01 | 2004-05-13 | Alk-Abelló A/S | Recombinant protein variants |
-
2002
- 2002-03-04 EP EP02713767A patent/EP1499349B1/de not_active Expired - Lifetime
- 2002-03-04 WO PCT/US2002/006765 patent/WO2002070665A2/en active Application Filing
- 2002-03-04 AT AT02713767T patent/ATE448793T1/de not_active IP Right Cessation
- 2002-03-04 US US10/091,135 patent/US20030039660A1/en not_active Abandoned
- 2002-03-04 CA CA002441476A patent/CA2441476A1/en not_active Abandoned
- 2002-03-04 CN CNA02809204XA patent/CN1610556A/zh active Pending
- 2002-03-04 DE DE60234475T patent/DE60234475D1/de not_active Expired - Lifetime
- 2002-03-04 DK DK02713767.8T patent/DK1499349T3/da active
- 2002-03-04 JP JP2002570693A patent/JP2005508134A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2005508134A (ja) | 2005-03-31 |
CN1610556A (zh) | 2005-04-27 |
EP1499349B1 (de) | 2009-11-18 |
WO2002070665A2 (en) | 2002-09-12 |
US20030039660A1 (en) | 2003-02-27 |
EP1499349A2 (de) | 2005-01-26 |
DE60234475D1 (de) | 2009-12-31 |
CA2441476A1 (en) | 2002-09-12 |
WO2002070665A3 (en) | 2004-11-11 |
EP1499349A4 (de) | 2005-11-16 |
DK1499349T3 (da) | 2010-04-06 |
WO2002070665A8 (en) | 2004-12-16 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |