AU2006224529B2 - Cat allergen fusion proteins and uses thereof - Google Patents

Cat allergen fusion proteins and uses thereof Download PDF

Info

Publication number
AU2006224529B2
AU2006224529B2 AU2006224529A AU2006224529A AU2006224529B2 AU 2006224529 B2 AU2006224529 B2 AU 2006224529B2 AU 2006224529 A AU2006224529 A AU 2006224529A AU 2006224529 A AU2006224529 A AU 2006224529A AU 2006224529 B2 AU2006224529 B2 AU 2006224529B2
Authority
AU
Australia
Prior art keywords
fel
seq
composition
chain
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006224529A
Other languages
English (en)
Other versions
AU2006224529A1 (en
Inventor
Martin Bachmann
Monika Bauer
Klaus Dietmeier
Nicole Schmitz
Stephan Utzinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytos Biotechnology AG
Original Assignee
Cytos Biotechnology AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytos Biotechnology AG filed Critical Cytos Biotechnology AG
Publication of AU2006224529A1 publication Critical patent/AU2006224529A1/en
Application granted granted Critical
Publication of AU2006224529B2 publication Critical patent/AU2006224529B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2006224529A 2005-03-18 2006-03-17 Cat allergen fusion proteins and uses thereof Ceased AU2006224529B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66291805P 2005-03-18 2005-03-18
US60/662,918 2005-03-18
PCT/EP2006/060845 WO2006097530A2 (en) 2005-03-18 2006-03-17 Cat allergen fusion proteins and uses thereof

Publications (2)

Publication Number Publication Date
AU2006224529A1 AU2006224529A1 (en) 2006-09-21
AU2006224529B2 true AU2006224529B2 (en) 2012-05-24

Family

ID=36843236

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006224529A Ceased AU2006224529B2 (en) 2005-03-18 2006-03-17 Cat allergen fusion proteins and uses thereof

Country Status (19)

Country Link
US (3) US7767212B2 (OSRAM)
EP (1) EP1868642B1 (OSRAM)
JP (2) JP5302671B2 (OSRAM)
KR (1) KR20070112225A (OSRAM)
CN (2) CN101141979B (OSRAM)
AU (1) AU2006224529B2 (OSRAM)
BR (1) BRPI0608455A2 (OSRAM)
CA (1) CA2599218C (OSRAM)
CY (1) CY1114171T1 (OSRAM)
DK (1) DK1868642T3 (OSRAM)
ES (1) ES2424229T3 (OSRAM)
IL (1) IL185103A0 (OSRAM)
MX (1) MX2007011160A (OSRAM)
NZ (1) NZ561040A (OSRAM)
PL (1) PL1868642T3 (OSRAM)
PT (1) PT1868642E (OSRAM)
RU (1) RU2414239C2 (OSRAM)
WO (1) WO2006097530A2 (OSRAM)
ZA (1) ZA200707413B (OSRAM)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
ES2335979T3 (es) 2001-09-14 2010-04-07 Cytos Biotechnology Ag Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso.
CN102061288A (zh) * 2002-07-17 2011-05-18 希托斯生物技术股份公司 使用衍生自ap205外壳蛋白的病毒样颗粒的分子抗原阵列
CA2492930C (en) * 2002-07-19 2013-01-08 Cytos Biotechnology Ag Vaccine compositions containing amyloid beta1-6 antigen arrays
NZ561040A (en) * 2005-03-18 2009-04-30 Cytos Biotechnology Ag Cat allergen fusion proteins and use thereof
CA2636139A1 (en) * 2005-12-14 2007-06-21 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
WO2007113633A2 (en) * 2006-04-03 2007-10-11 Pfizer Products Inc. Immunogenic compositions comprising cat allergen fel dl
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
EP2530086B1 (en) 2006-06-12 2019-03-20 Kuros Biosciences AG Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages
AU2007303608B2 (en) 2006-09-29 2013-05-02 Takeda Vaccines, Inc. Norovirus vaccine formulations
US9388236B2 (en) 2007-07-09 2016-07-12 Nestec Sa Methods for reducing allergies caused by environmental allergens
DK2162133T3 (en) 2007-07-09 2016-10-24 Nestec Sa Approaches to reduce allergies caused by environmental allergens
CN101918028B (zh) 2007-09-18 2015-01-07 莱戈赛特医药股份有限公司 赋予针对诺如病毒的保护性免疫应答的疫苗
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
EP2042193A1 (en) * 2007-09-28 2009-04-01 Biomay AG RNA Vaccines
JP5852883B2 (ja) 2008-08-08 2016-02-03 タケダ ワクチン,インコーポレイテッド 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子
DE112010006063B4 (de) * 2009-11-05 2018-12-27 Novici Biotech Llc Erzeugung von Antigenen, virusartigen Partikeln über Protein-Protein-Bindungen
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
DK3299030T3 (da) 2011-07-11 2022-09-05 Takeda Vaccines Inc Parenterale norovirus-vaccineformuleringer
CA2854246A1 (en) 2011-12-22 2013-06-27 F. Hoffmann-La Roche Ag Full length antibody display system for eukaryotic cells and its use
JO3820B1 (ar) * 2012-05-03 2021-01-31 Regeneron Pharma أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
US9657076B2 (en) * 2012-10-23 2017-05-23 Emory University GM-CSF and IL-4 conjugates, compositions, and methods related thereto
WO2015027154A2 (en) 2013-08-23 2015-02-26 Regeneron Pharmaceuticals, Inc. Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit)
US20150175940A1 (en) * 2013-12-19 2015-06-25 Nestec Sa Compositions and methods for reducing cat allergens in the environment
MA40824A (fr) 2014-10-22 2017-08-29 Saiba Gmbh Particules de cmv de type virus modifié
EA035378B1 (ru) 2015-01-15 2020-06-04 Юниверсити Оф Копенгаген Вирусоподобная частица с эффективным экспонированием эпитопов
WO2016192788A1 (en) * 2015-06-03 2016-12-08 Universität Zürich Prorektorat Mnw Methods and compositions for preventing and treating cat or dog dander allergy
US10835600B2 (en) * 2015-09-08 2020-11-17 Universität Zürich Compositions against cat allergy
DK3368068T3 (da) 2015-10-30 2021-02-22 Univ Copenhagen Viruslignende partikler med effektiv epitopdisplay
CN105219742A (zh) * 2015-11-10 2016-01-06 海南大学 一种展示重组猫致敏原rFel d 1蛋白的免疫增强型病毒样颗粒、其表达载体及其制备与应用
WO2017179025A1 (en) 2016-04-15 2017-10-19 Alk-Abelló A/S Epitope polypeptides of ragweed pollen allergens
FR3054547B1 (fr) * 2016-07-29 2020-06-05 Angany Inc. Particules pseudo-virales et leurs utilisations
WO2018118713A1 (en) 2016-12-22 2018-06-28 Regeneron Pharmaceuticals, Inc. Method of treating an allergy with allergen-specific monoclonal antibodies
SG11202104486VA (en) 2018-12-20 2021-05-28 Saiba AG Virus-like particles of cmv modified by fusion
CN118871591A (zh) * 2022-03-18 2024-10-29 电化株式会社 包含通过接头连接的衣壳蛋白的病毒样颗粒
CN114933639B (zh) * 2022-05-05 2023-12-29 中国农业科学院兰州兽医研究所 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途
CN117004650B (zh) * 2023-06-25 2024-05-14 山东立菲生物产业有限公司 一种猫皮屑过敏原组分feld1双链二聚体重组蛋白、制备方法及应用
WO2025139524A1 (zh) * 2023-12-28 2025-07-03 江苏众红生物工程创药研究院有限公司 猫重组变应原及其药用组合物、制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032227A2 (en) * 1998-11-30 2000-06-08 Cytos Biotechnology Ag Ordered molecular presentation of antigens, method of preparation and use

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163778A (en) * 1978-05-04 1979-08-07 The Foundation for the Study of Asthma and Related Diseases Asthma immunotherapy
US5374426A (en) * 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
AU633007B2 (en) * 1988-06-14 1993-01-21 Cell-Sci Corporation Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same
US6120769A (en) * 1989-11-03 2000-09-19 Immulogic Pharmaceutical Corporation Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
WO1992011291A1 (en) 1990-12-20 1992-07-09 Smithkline Beecham Biologicals (S.A.) Vaccines based on hepatitis b surface antigen
GB9114003D0 (en) * 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
GB9213601D0 (en) * 1992-06-26 1992-08-12 Mastico Robert A Protein based delivery system
US6759234B1 (en) * 1994-09-02 2004-07-06 Immulogic Pharmaceutical Corporation Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
AU7726094A (en) 1994-09-02 1996-03-27 Immulogic Pharmaceutical Corporation Peptide compositions capable of down regulating an antigen specific immune response
CN1185811A (zh) 1995-03-31 1998-06-24 H·沃尔夫 依赖于逆转录病毒样颗粒的抗原呈递系统
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
US6054312A (en) * 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
WO1999030736A2 (en) * 1997-12-16 1999-06-24 Regents Of The University Of Minnesota Methods to treat undesirable immune responses
AR020102A1 (es) 1998-07-30 2002-04-10 Ucb Sa Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento
WO2000020032A1 (en) 1998-10-06 2000-04-13 Trustees Of Dartmouth College RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
JP4486257B2 (ja) * 1998-10-21 2010-06-23 アメリカ合衆国 自己抗体の誘導のためのウイルス様粒子
SK287400B6 (sk) 1999-09-25 2010-08-09 University Of Iowa Research Foundation Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie
CA2407897A1 (en) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
DE60136653D1 (de) 2000-11-16 2009-01-02 Alk Abello As Mutante allergene
DK1219300T3 (da) 2000-12-28 2007-03-05 Biomay Prod & Handel Behandling af allergi
EP1221317A1 (en) * 2000-12-28 2002-07-10 SHAN-Beteiligungsgesellschaft m.b.H. Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
ATE448793T1 (de) 2001-03-02 2009-12-15 Univ Rockefeller Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens
ES2335979T3 (es) 2001-09-14 2010-04-07 Cytos Biotechnology Ag Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso.
WO2003024480A2 (en) 2001-09-14 2003-03-27 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
ATE412428T1 (de) * 2001-11-07 2008-11-15 Cytos Biotechnology Ag Antigen-raster enthaltend rankl zur behandlung von knochenerkrankungen
NZ532516A (en) * 2001-11-07 2008-05-30 Cytos Biotechnology Ag Antigen arrays presenting IL-5, IL-13 or eotaxin for treatment of allergic eosinophilic diseases
CN102061288A (zh) * 2002-07-17 2011-05-18 希托斯生物技术股份公司 使用衍生自ap205外壳蛋白的病毒样颗粒的分子抗原阵列
CN1665565A (zh) 2002-07-19 2005-09-07 赛托斯生物技术公司 Ghrelin-载体偶联物
EP1530585A2 (en) * 2002-08-22 2005-05-18 Cytos Biotechnology AG Inducible alphaviral/orip based gene expression system
WO2004039834A2 (en) 2002-11-01 2004-05-13 Alk-Abelló A/S Recombinant protein variants
WO2004047793A1 (en) 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
CA2517839A1 (en) * 2003-03-26 2004-10-07 Martin F. Bachmann Melan-a peptide analogue-virus-like-particle conjugates
ATE384741T1 (de) * 2003-04-24 2008-02-15 Imvision Gmbh Rekombinantes fel d 1 allergen
JP2009513532A (ja) * 2003-07-10 2009-04-02 サイトス バイオテクノロジー アーゲー パッケージ化ウイルス様粒子
NZ561040A (en) * 2005-03-18 2009-04-30 Cytos Biotechnology Ag Cat allergen fusion proteins and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032227A2 (en) * 1998-11-30 2000-06-08 Cytos Biotechnology Ag Ordered molecular presentation of antigens, method of preparation and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Gronlund, H. et al (2003) The Journal of Biological Chemistry. V278 pp40144-40151 *
Kaiser, L. et al (2003) The Journal of Biological Chemistry. V278 pp37730-37735 *
Vailes, LD et al (2002) Journal of Allergy and Clinical Immunology. V110 pp757-762 *

Also Published As

Publication number Publication date
RU2007138265A (ru) 2009-04-27
EP1868642A2 (en) 2007-12-26
NZ561040A (en) 2009-04-30
CA2599218C (en) 2015-08-11
JP2008535800A (ja) 2008-09-04
BRPI0608455A2 (pt) 2010-01-05
PL1868642T3 (pl) 2013-10-31
ES2424229T3 (es) 2013-09-30
CA2599218A1 (en) 2006-09-21
CN103203016A (zh) 2013-07-17
CN101141979B (zh) 2013-05-08
JP2013155176A (ja) 2013-08-15
US20110045013A1 (en) 2011-02-24
US7767212B2 (en) 2010-08-03
US20090175896A1 (en) 2009-07-09
ZA200707413B (en) 2009-01-28
AU2006224529A1 (en) 2006-09-21
JP5302671B2 (ja) 2013-10-02
CY1114171T1 (el) 2016-08-31
IL185103A0 (en) 2007-12-03
KR20070112225A (ko) 2007-11-22
EP1868642B1 (en) 2013-05-08
DK1868642T3 (da) 2013-06-24
WO2006097530A3 (en) 2007-06-21
MX2007011160A (es) 2007-11-13
WO2006097530A2 (en) 2006-09-21
RU2414239C2 (ru) 2011-03-20
US20130344098A1 (en) 2013-12-26
PT1868642E (pt) 2013-07-10
CN101141979A (zh) 2008-03-12

Similar Documents

Publication Publication Date Title
AU2006224529B2 (en) Cat allergen fusion proteins and uses thereof
US8449874B2 (en) Interleukin-1 muteins linked to virus-like particles to treat IL-1 associated diseases
US20090123414A1 (en) Il-15 Antigen Arrays And Uses Thereof
CA2664418A1 (en) Interleukin-1 muteins linked to virus-like particles to treat il-1 associated diseases
US20110318300A1 (en) User of Interleukin-1 Conjugates in the Treatment of Diabetes
WO2007039458A2 (en) Hiv peptide conjugates and uses thereof
AU2013202547A1 (en) Interleukin-1 conjugates and uses thereof

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired