CY1112562T1 - Φαρμακευτικες συνθεσεις για τη στοματικη χορηγηση της καλσιτονινης - Google Patents
Φαρμακευτικες συνθεσεις για τη στοματικη χορηγηση της καλσιτονινηςInfo
- Publication number
- CY1112562T1 CY1112562T1 CY20111100759T CY111100759T CY1112562T1 CY 1112562 T1 CY1112562 T1 CY 1112562T1 CY 20111100759 T CY20111100759 T CY 20111100759T CY 111100759 T CY111100759 T CY 111100759T CY 1112562 T1 CY1112562 T1 CY 1112562T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical compositions
- oral administration
- pharmaceutically active
- kalsitonin
- agent
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960000913 crospovidone Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 abstract 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 229940069328 povidone Drugs 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Abstract
Στο παρόν περιέχονται στερεές φαρμακευτικές συνθέσεις κατάλληλες για τη στοματική χορήγηση φαρμακευτικά ενεργών παραγόντων, π.χ. πεπτιδίων, που περιλαμβάνουν μια θεραπευτικά αποτελεσματική ποσότητα ενός φαρμακευτικά ενεργού παράγοντα ˙ μια κροσποβιδόνη ή ποβιδόνη ˙ και έναν παράγοντα χορήγησης του εν λόγω φαρμακευτικά ενεργού παράγοντα. Οι συνθέσεις παρέχουν εξαίρετη στοματική βιοδιαθεσιμότητα φαρμακευτικά ενεργών παραγόντων, και ιδίως της καλσιτονίνης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25172900P | 2000-12-06 | 2000-12-06 | |
EP01985368A EP1341526B1 (en) | 2000-12-06 | 2001-12-05 | Pharmaceutical compositions for the oral delivery of calcitonin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112562T1 true CY1112562T1 (el) | 2016-02-10 |
Family
ID=22953160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100759T CY1112562T1 (el) | 2000-12-06 | 2011-08-09 | Φαρμακευτικες συνθεσεις για τη στοματικη χορηγηση της καλσιτονινης |
Country Status (27)
Country | Link |
---|---|
US (1) | US7049283B2 (el) |
EP (1) | EP1341526B1 (el) |
JP (2) | JP4898078B2 (el) |
KR (1) | KR100847695B1 (el) |
CN (1) | CN1304048C (el) |
AT (1) | ATE513541T1 (el) |
AU (2) | AU2002234547B2 (el) |
BR (2) | BRPI0115965B1 (el) |
CA (1) | CA2436599C (el) |
CY (1) | CY1112562T1 (el) |
CZ (1) | CZ305418B6 (el) |
DK (1) | DK1341526T3 (el) |
EC (1) | ECSP034639A (el) |
ES (1) | ES2367009T3 (el) |
HK (1) | HK1059565A1 (el) |
HU (1) | HU230632B1 (el) |
IL (2) | IL155992A0 (el) |
MX (1) | MXPA03005096A (el) |
NO (1) | NO332936B1 (el) |
NZ (1) | NZ526196A (el) |
PL (1) | PL209703B1 (el) |
PT (1) | PT1341526E (el) |
RU (1) | RU2287999C2 (el) |
SI (1) | SI1341526T1 (el) |
SK (1) | SK287613B6 (el) |
WO (1) | WO2002045754A2 (el) |
ZA (1) | ZA200304295B (el) |
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ES2235854T3 (es) | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
PT1397156E (pt) * | 2001-06-01 | 2007-05-31 | Novartis Ag | Método para a administração oral da hormona paratireóide ( pth ). |
US20050054557A1 (en) * | 2002-05-09 | 2005-03-10 | Goldberg Michael M. | Compositions for delivering parathyroid hormone and calcitonin |
TW200403052A (en) | 2002-07-17 | 2004-03-01 | Novartis Ag | Use of organic compounds |
TWI307279B (en) * | 2002-08-01 | 2009-03-11 | Novartis Ag | Oral administration of calcitonin |
ES2377121T3 (es) * | 2003-03-17 | 2012-03-22 | Japan Tobacco Inc. | Composiciones farmacéuticas de inhibidores de CETP |
TWI494102B (zh) * | 2003-05-02 | 2015-08-01 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
CN1809377B (zh) * | 2003-07-11 | 2010-08-04 | 诺瓦提斯公司 | 包含微粉化形式的传送剂的口服给药药物组合物 |
DK2821067T3 (en) * | 2003-09-12 | 2017-12-04 | Amgen Inc | Quick solution formulation of cinacalcet |
NZ588373A (en) * | 2004-05-19 | 2012-01-12 | Emisphere Tech Inc | Topical cromolyn formulations |
GB0422644D0 (en) * | 2004-10-12 | 2004-11-10 | Novartis Ag | Organic compounds |
GB0427603D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
US20080153779A1 (en) * | 2005-02-01 | 2008-06-26 | Jun Liao | Gastric Retention and Controlled Release Delivery System |
US8030271B2 (en) * | 2005-07-05 | 2011-10-04 | Emisphere Technologies, Inc. | Compositions and methods for buccal delivery of human growth hormone |
RU2507196C2 (ru) | 2005-09-19 | 2014-02-20 | Эмисфире Текнолоджис, Инк. | Кристаллические формы динатриевой соли n-(5-хлорсалицилоил)-8-аминокаприловой кислоты |
GB0522566D0 (en) | 2005-11-04 | 2005-12-14 | Novartis Ag | Organic compounds |
CA2626933C (en) * | 2005-11-17 | 2015-12-29 | Novartis Ag | Pharmaceutical composition |
CA2642761A1 (en) * | 2006-02-23 | 2007-08-30 | Iomedix Sleep International Srl | Compositions and methods for the induction and maintenance of quality sleep |
CA2659655A1 (en) * | 2006-08-08 | 2008-02-21 | Alan M. Fogelman | Salicylanilides enhance oral delivery of therapeutic peptides |
JP5042312B2 (ja) * | 2006-08-31 | 2012-10-03 | ノバルティス アーゲー | Hghを含む経口送達用医薬組成物 |
CA2572004A1 (en) * | 2006-12-08 | 2008-06-08 | Bernard Charles Sherman | Tablets comprising entacapone and crospovidone |
MX2009009243A (es) * | 2007-03-02 | 2009-09-08 | Novartis Ag | Administracion oral de una calcitonina. |
DK2215047T3 (da) | 2007-11-02 | 2014-02-03 | Emisphere Tech Inc | Fremgangsmåde til behandling af vitamin b12-mangel |
AU2009283821B2 (en) | 2008-08-18 | 2014-05-29 | Entera Bio Ltd. | Methods and compositions for oral administration of proteins |
EP2762150A1 (en) * | 2009-03-12 | 2014-08-06 | Nordic Bioscience A/S | Treatment of Diabetes and Metabolic Syndrome |
KR101811376B1 (ko) * | 2010-06-09 | 2017-12-22 | 에미스페어 테크놀로지스, 인코포레이티드 | 경구용 철 결핍증 치료 |
RU2600440C3 (ru) | 2010-12-16 | 2021-12-10 | Ново Нордиск А/С | Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты |
CN106117344B (zh) | 2011-04-12 | 2020-11-03 | 诺沃—诺迪斯克有限公司 | 双酰化glp-1衍生物 |
HRP20231613T1 (hr) | 2012-03-22 | 2024-03-15 | Novo Nordisk A/S | Pripravci koji sadrže sredstvo za unošenje i njihova priprava |
ES2715308T3 (es) | 2012-03-22 | 2019-06-03 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y su preparación |
US10933120B2 (en) | 2012-03-22 | 2021-03-02 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
EP2863895B1 (en) | 2012-06-20 | 2021-04-14 | Novo Nordisk A/S | Tablet formulation comprising a peptide and a delivery agent |
CN104961687B (zh) * | 2015-06-03 | 2017-07-25 | 苏州维泰生物技术有限公司 | 1,2‑二嗪衍生物及其制剂、用途 |
ES2784703T3 (es) * | 2015-07-08 | 2020-09-30 | Research & Business Found Sungkyunkwan Univ | Derivados de la pirrolidina carboxamida y métodos para preparar y utilizar la misma |
EA036204B1 (ru) * | 2015-10-16 | 2020-10-14 | Нобел Илач Санайи Ве Тиджарет А.Ш. | Фармацевтические композиции нилотиниба гидрохлорида |
CN107080739A (zh) * | 2017-04-17 | 2017-08-22 | 深圳市泛谷药业股份有限公司 | 一种用于口服给药的固体快速释放布南色林片及其制备方法 |
EP3746111B1 (en) | 2018-02-02 | 2023-07-19 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
JP2021054781A (ja) * | 2019-09-26 | 2021-04-08 | デボン エルエス,リミテッド | 共結晶形エフィナコナゾール、及びその製造方法 |
KR102301743B1 (ko) * | 2020-12-29 | 2021-09-13 | 대봉엘에스 주식회사 | 에피나코나졸 경구용 조성물 |
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US5756450A (en) | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
US5002771A (en) | 1989-02-06 | 1991-03-26 | Rorer Pharmaceutical Corp. | Calcitonin suppository formulations |
IT1238072B (it) | 1990-01-19 | 1993-07-03 | Sclavo Spa | Composizioni farmaceutiche e forme di dosaggio per la somministrazione orale di calcitonina |
JPH052771A (ja) * | 1991-06-25 | 1993-01-08 | Pioneer Electron Corp | 光記録媒体 |
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DK0800384T3 (da) | 1994-12-14 | 2001-04-17 | Enbalt Trading Ltd | Pharmaceutiske tabletformuleringer til direkte kompression |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
CN1151836C (zh) * | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
US5912014A (en) * | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
US5972381A (en) | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
EP0839526A3 (en) * | 1996-10-31 | 1999-01-07 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with fast buccal disintegration or dissolution |
CA2279331C (en) | 1997-02-07 | 2010-04-20 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
SI20413A (sl) | 1998-03-16 | 2001-06-30 | Inhale Therapeutic Systems, Inc. | Dajanje aerosoliziranega aktivnega sredstva |
AU3574500A (en) | 1999-03-25 | 2000-10-16 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
ES2235854T3 (es) * | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
WO2000059480A1 (en) * | 1999-04-05 | 2000-10-12 | Emisphere Technologies, Inc. | Lyophilized solid dosage forms and methods of making |
-
2001
- 2001-12-04 US US10/006,311 patent/US7049283B2/en not_active Expired - Fee Related
- 2001-12-05 PL PL362247A patent/PL209703B1/pl unknown
- 2001-12-05 WO PCT/EP2001/014294 patent/WO2002045754A2/en active IP Right Grant
- 2001-12-05 DK DK01985368.8T patent/DK1341526T3/da active
- 2001-12-05 HU HU0302319A patent/HU230632B1/hu not_active IP Right Cessation
- 2001-12-05 AU AU2002234547A patent/AU2002234547B2/en not_active Ceased
- 2001-12-05 JP JP2002547536A patent/JP4898078B2/ja not_active Expired - Fee Related
- 2001-12-05 PT PT01985368T patent/PT1341526E/pt unknown
- 2001-12-05 SK SK688-2003A patent/SK287613B6/sk not_active IP Right Cessation
- 2001-12-05 KR KR1020037007098A patent/KR100847695B1/ko not_active IP Right Cessation
- 2001-12-05 CZ CZ2003-1566A patent/CZ305418B6/cs not_active IP Right Cessation
- 2001-12-05 EP EP01985368A patent/EP1341526B1/en not_active Expired - Lifetime
- 2001-12-05 AT AT01985368T patent/ATE513541T1/de active
- 2001-12-05 BR BRPI0115965-8A patent/BRPI0115965B1/pt unknown
- 2001-12-05 IL IL15599201A patent/IL155992A0/xx active IP Right Grant
- 2001-12-05 SI SI200130999T patent/SI1341526T1/sl unknown
- 2001-12-05 RU RU2003119545/15A patent/RU2287999C2/ru not_active IP Right Cessation
- 2001-12-05 MX MXPA03005096A patent/MXPA03005096A/es active IP Right Grant
- 2001-12-05 BR BR0115965-8A patent/BR0115965A/pt not_active IP Right Cessation
- 2001-12-05 ES ES01985368T patent/ES2367009T3/es not_active Expired - Lifetime
- 2001-12-05 NZ NZ526196A patent/NZ526196A/en not_active IP Right Cessation
- 2001-12-05 AU AU3454702A patent/AU3454702A/xx active Pending
- 2001-12-05 CN CNB018201423A patent/CN1304048C/zh not_active Expired - Fee Related
- 2001-12-05 CA CA2436599A patent/CA2436599C/en not_active Expired - Fee Related
-
2003
- 2003-05-19 IL IL155992A patent/IL155992A/en not_active IP Right Cessation
- 2003-06-02 ZA ZA200304295A patent/ZA200304295B/en unknown
- 2003-06-03 NO NO20032511A patent/NO332936B1/no not_active IP Right Cessation
- 2003-06-04 EC EC2003004639A patent/ECSP034639A/es unknown
-
2004
- 2004-02-11 HK HK04100920.1A patent/HK1059565A1/xx not_active IP Right Cessation
-
2009
- 2009-04-13 JP JP2009097262A patent/JP2009185052A/ja not_active Withdrawn
-
2011
- 2011-08-09 CY CY20111100759T patent/CY1112562T1/el unknown
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