DE60019167D1 - Pharmazeutische aerosol formulierung enthaltend salmeterol und fluticason - Google Patents
Pharmazeutische aerosol formulierung enthaltend salmeterol und fluticasonInfo
- Publication number
- DE60019167D1 DE60019167D1 DE60019167T DE60019167T DE60019167D1 DE 60019167 D1 DE60019167 D1 DE 60019167D1 DE 60019167 T DE60019167 T DE 60019167T DE 60019167 T DE60019167 T DE 60019167T DE 60019167 D1 DE60019167 D1 DE 60019167D1
- Authority
- DE
- Germany
- Prior art keywords
- fluticasone
- aerosol formulation
- pharmaceutical aerosol
- formulation containing
- salmeterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9930878.5A GB9930878D0 (en) | 1999-12-24 | 1999-12-24 | Pharmaceutical formulation |
GB9930878 | 1999-12-24 | ||
GB0018686A GB0018686D0 (en) | 2000-07-28 | 2000-07-28 | Pharmaceutical formulation |
GB0018686 | 2000-07-28 | ||
PCT/GB2000/004939 WO2001047493A1 (en) | 1999-12-24 | 2000-12-21 | Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60019167D1 true DE60019167D1 (de) | 2005-05-04 |
DE60019167T2 DE60019167T2 (de) | 2006-05-11 |
Family
ID=26244762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60019167T Expired - Lifetime DE60019167T2 (de) | 1999-12-24 | 2000-12-21 | Pharmazeutische aerosol formulierung enthaltend salmeterol und fluticason |
Country Status (8)
Country | Link |
---|---|
US (1) | US20030032632A1 (de) |
EP (1) | EP1248597B1 (de) |
JP (1) | JP2003518484A (de) |
AT (1) | ATE291898T1 (de) |
AU (1) | AU2206801A (de) |
DE (1) | DE60019167T2 (de) |
ES (1) | ES2238334T3 (de) |
WO (1) | WO2001047493A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
WO2001037805A1 (en) * | 1999-11-23 | 2001-05-31 | Glaxo Group Limited | Pharmaceutical formulations of salmeterol |
US20050048001A1 (en) * | 1999-11-23 | 2005-03-03 | Cripps Alan Leslie | Pharmaceutical formulations of salmeterol |
IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
ME00220B (me) | 2000-05-22 | 2010-10-10 | Chiesi Farm Spa | Stabilne farmaceutske formulacije rastvora za inhalatore odmjerene doze pod pritiskom |
GB2367011A (en) * | 2000-08-26 | 2002-03-27 | Glaxo Group Ltd | Metered dose inhaler for salmeterol |
PE20020387A1 (es) * | 2000-08-31 | 2002-06-24 | Glaxo Group Ltd | Uso de una combinacion de salmeterol y fluticasona |
GB0021927D0 (en) * | 2000-09-07 | 2000-10-25 | Glaxo Group Ltd | Use of pharmaceutical combination |
GB0105560D0 (en) * | 2001-03-07 | 2001-04-25 | Glaxo Group Ltd | Pharmaceutical formulations |
GB0106031D0 (en) * | 2001-03-12 | 2001-05-02 | Glaxo Group Ltd | Use |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
EP1465869B1 (de) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulatoren von lxr |
EP1415647A1 (de) * | 2002-10-23 | 2004-05-06 | CHIESI FARMACEUTICI S.p.A. | Langwirkende beta-2-Agonisten in ultrafeiner Formulierung |
DK1542904T3 (da) * | 2002-08-27 | 2008-04-21 | Schering Corp | Fremgangsmåde til fremstilling af formuleringer til en inhalator med målte doser |
EP1811981B1 (de) * | 2004-10-12 | 2008-08-13 | Merck Generics (UK) Limited | Verfahren zur herstellung von suspensionsaerosolformulierungen, worin die partikel durch präzipition in einem aerosolbehälter gebildet werden |
US7680778B2 (en) * | 2007-01-19 | 2010-03-16 | Microsoft Corporation | Support for reverse and stemmed hit-highlighting |
GB0712454D0 (en) | 2007-06-27 | 2007-08-08 | Generics Uk Ltd | Pharmaceutical compositions |
US20130064870A1 (en) * | 2010-05-20 | 2013-03-14 | Sun Pharma Advanced Research Company Limited | Dry powder inhalation composition |
TWI399202B (zh) * | 2011-03-17 | 2013-06-21 | Intech Biopharm Ltd | 製備用於治療呼吸道疾病之定量噴霧吸入劑的製程方法 |
BR112014003907A2 (pt) | 2011-08-19 | 2017-06-13 | Intech Biopharm Ltd. | método para preparar inalador pulverizado de dose medida para tratar doença respiratória |
CN102379846B (zh) * | 2011-10-21 | 2014-07-02 | 江苏长风药业有限公司 | 以氢氟烷烃和聚乙二醇为辅料氟替卡松丙酸酯气雾剂制剂 |
EP2847207B1 (de) | 2012-05-08 | 2019-03-27 | Nicox Ophthalmics, Inc. | Nanokristalle von Fluticasonpropionat |
US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
SG11201610685XA (en) * | 2014-06-25 | 2017-01-27 | Optinose As | Nasal administration |
WO2016018892A1 (en) | 2014-07-29 | 2016-02-04 | 3M Innovative Properties Company | Method of preparing a pharmaceutical composition |
BR112019005168A2 (pt) * | 2016-09-19 | 2019-06-11 | Mexichem Fluor Sa De Cv | composição farmacêutica, recipiente vedado, inalador de dose medida, e, métodos para tratar um paciente que sofre ou susceptível de sofrer de um distúrbio respiratório, para melhoria da estabilidade de uma composição farmacêutica e do desempenho de aerossolização de uma composição farmacêutica e para reduzir o potencial de aquecimento global de uma composição farmacêutica |
EP3515432B1 (de) | 2016-09-19 | 2021-08-25 | Mexichem Fluor S.A. de C.V. | Pharmazeutische zusammensetzung enthaltend glycopyrrolate |
CA3037080C (en) | 2016-09-19 | 2021-05-18 | Mexichem Fluor S.A. De C.V. | Stable pharmaceutical compositions comprising indacaterol and 1,1-difluoroethane (hfa-152a) suitable for use in metered dose inhalers (mdis) |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE629985A (de) * | 1962-11-29 | |||
CH634480A5 (de) * | 1977-11-25 | 1983-02-15 | Schwarzkopf Gmbh Hans | Unter druck stehendes aerosolpraeparat. |
IL95590A (en) * | 1989-09-08 | 1996-06-18 | Glaxo Group Ltd | Medicinal preparations containing Salmetrol and Pluticasone Propionate |
US5919827A (en) * | 1990-07-11 | 1999-07-06 | Sepracor Inc. | Method for treating asthma using optically pure R(-) salmeterol |
MX9203481A (es) * | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
DE69105212T2 (de) * | 1990-10-18 | 1995-03-23 | Minnesota Mining & Mfg | Aerosolzubereitung, die beclometason 17,21-dipropionat enthält. |
US5736124A (en) * | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
US5653962A (en) * | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
KR100312357B1 (ko) * | 1992-12-09 | 2002-04-24 | 데이비드 이. 프랭크하우저 | 안정화된약제의에어로졸용액제제 |
DE4446891A1 (de) * | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
NZ336049A (en) * | 1996-12-04 | 2000-09-29 | Bioglan Ireland R & D Ltd | Aersol device for administering pharmaceutical active agents in a solution of propellant, carrier and valve means for delivering this to the exterior of the container |
AU718967B2 (en) * | 1997-02-05 | 2000-05-04 | Jagotec Ag | Medical aerosol formulations |
GB2326334A (en) * | 1997-06-13 | 1998-12-23 | Chiesi Farma Spa | Pharmaceutical aerosol compositions |
US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
GB2332372B (en) * | 1997-12-08 | 2002-08-14 | Minnesota Mining & Mfg | Pharmaceutical aerosol compositions |
GB9808802D0 (en) * | 1998-04-24 | 1998-06-24 | Glaxo Group Ltd | Pharmaceutical formulations |
ES2211108T3 (es) * | 1998-06-18 | 2004-07-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Formulaciones farmaceuticas para aerosoles con dos o mas sustancias activas. |
US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
IT1303788B1 (it) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
US6004537A (en) * | 1998-12-18 | 1999-12-21 | Baker Norton Pharmaceuticals, Inc. | Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol |
US6231519B1 (en) * | 1999-05-04 | 2001-05-15 | Nokia Corporation | Method and apparatus for providing air quality analysis based on human reactions and clustering methods |
US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
CA2317999C (en) * | 1999-09-11 | 2004-11-09 | Glaxo Group Limited | Pharmaceutical formulation of fluticasone propionate |
IL150486A0 (en) * | 2000-01-31 | 2002-12-01 | Pfizer Prod Inc | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes |
-
2000
- 2000-12-21 ES ES00985666T patent/ES2238334T3/es not_active Expired - Lifetime
- 2000-12-21 DE DE60019167T patent/DE60019167T2/de not_active Expired - Lifetime
- 2000-12-21 WO PCT/GB2000/004939 patent/WO2001047493A1/en active IP Right Grant
- 2000-12-21 US US10/168,672 patent/US20030032632A1/en not_active Abandoned
- 2000-12-21 AU AU22068/01A patent/AU2206801A/en not_active Abandoned
- 2000-12-21 AT AT00985666T patent/ATE291898T1/de not_active IP Right Cessation
- 2000-12-21 JP JP2001548088A patent/JP2003518484A/ja active Pending
- 2000-12-21 EP EP00985666A patent/EP1248597B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2001047493A1 (en) | 2001-07-05 |
DE60019167T2 (de) | 2006-05-11 |
AU2206801A (en) | 2001-07-09 |
ATE291898T1 (de) | 2005-04-15 |
ES2238334T3 (es) | 2005-09-01 |
US20030032632A1 (en) | 2003-02-13 |
EP1248597B1 (de) | 2005-03-30 |
EP1248597A1 (de) | 2002-10-16 |
JP2003518484A (ja) | 2003-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |