CY1106305T1 - Ενεσιμη συνθεση αποθεματος πepιλαμβανουσα κρυσταλλους ιλοπepιδονης - Google Patents
Ενεσιμη συνθεση αποθεματος πepιλαμβανουσα κρυσταλλους ιλοπepιδονηςInfo
- Publication number
- CY1106305T1 CY1106305T1 CY20061101867T CY061101867T CY1106305T1 CY 1106305 T1 CY1106305 T1 CY 1106305T1 CY 20061101867 T CY20061101867 T CY 20061101867T CY 061101867 T CY061101867 T CY 061101867T CY 1106305 T1 CY1106305 T1 CY 1106305T1
- Authority
- CY
- Cyprus
- Prior art keywords
- crystals
- pepilamvanus
- ilopepidone
- deposit composition
- size
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 11
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000002596 correlated effect Effects 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- XMXHEBAFVSFQEX-UHFFFAOYSA-N iloperidone Chemical compound COC1=CC(C(C)=O)=CC=C1OCCCN1CCC(C=2C3=CC=C(F)C=C3ON=2)CC1 XMXHEBAFVSFQEX-UHFFFAOYSA-N 0.000 abstract 1
- 229960003162 iloperidone Drugs 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000003801 milling Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000012414 sterilization procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0216416.8A GB0216416D0 (en) | 2002-07-15 | 2002-07-15 | Organic compounds |
| PCT/EP2003/007619 WO2004006886A2 (en) | 2002-07-15 | 2003-07-14 | Injectable depot formulation comprising crystals of iloperidone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106305T1 true CY1106305T1 (el) | 2011-10-12 |
Family
ID=9940486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101867T CY1106305T1 (el) | 2002-07-15 | 2006-12-29 | Ενεσιμη συνθεση αποθεματος πepιλαμβανουσα κρυσταλλους ιλοπepιδονης |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US20050250813A1 (enExample) |
| EP (1) | EP1523335B1 (enExample) |
| JP (2) | JP5392961B2 (enExample) |
| AT (1) | ATE348635T1 (enExample) |
| AU (1) | AU2003281154B2 (enExample) |
| CA (1) | CA2492467C (enExample) |
| CY (1) | CY1106305T1 (enExample) |
| DE (1) | DE60310564T2 (enExample) |
| DK (1) | DK1523335T3 (enExample) |
| ES (1) | ES2279153T3 (enExample) |
| GB (1) | GB0216416D0 (enExample) |
| NZ (1) | NZ537598A (enExample) |
| PT (1) | PT1523335E (enExample) |
| WO (1) | WO2004006886A2 (enExample) |
| ZA (1) | ZA200410323B (enExample) |
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| BRPI0213564B8 (pt) | 2001-10-30 | 2021-05-25 | Novartis Ag | formulação depósito e micropartícula compreendendo iloperidona e polímero poli(d,l-lactídeo-co-glicolídeo), e processo para preparação da referida micropartícula |
| GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
| UA82561C2 (uk) | 2003-10-23 | 2008-04-25 | Оцука Фармасьютикалз Ко., Лтд. | Стерильна ін'єкційна композиція арипіпразолу з контрольованим вивільненням, спосіб її виготовлення та спосіб лікування шизофренії |
| US20100063093A1 (en) | 2007-03-28 | 2010-03-11 | Curt Wolfgang | Methods for the administration of iloperidone |
| WO2006039663A2 (en) | 2004-09-30 | 2006-04-13 | Vanda Pharmaceuticals, Inc | Methods for the administration of iloperidone |
| US20090306137A1 (en) | 2006-05-22 | 2009-12-10 | Wolfgang Curt D | Treatment for depressive disorders |
| US8198305B2 (en) | 2007-04-13 | 2012-06-12 | Concert Pharmaceuticals Inc. | 1,2-benzisoxazol-3-yl compounds |
| SI2170279T1 (en) | 2007-07-31 | 2018-04-30 | Otsuka Pharmaceutical Co., Ltd. | Methods for producing aripiprazole suspension and freeze-dried formulation |
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| EP2222301B1 (en) | 2007-12-13 | 2014-10-08 | Vanda Pharmaceuticals Inc. | Method and composition for treating an alpha adrenoceptor-mediated condition |
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| WO2010031497A1 (en) * | 2008-09-19 | 2010-03-25 | Miklos Vertessy | New process for the preparation of iloperidone |
| CN101822673B (zh) * | 2009-03-04 | 2013-09-18 | 北京德众万全药物技术开发有限公司 | 一种含有伊潘立酮的固体药物组合物 |
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| CN102030744B (zh) * | 2009-09-30 | 2013-04-17 | 天津药物研究院 | 伊潘立酮晶体、其制备方法及药物组合物 |
| WO2011055188A1 (en) * | 2009-11-05 | 2011-05-12 | Orchid Chemicals And Pharmaceuticals Limited | An improved process for the preparation of iloperidone |
| BR112012015084A2 (pt) * | 2009-12-23 | 2017-03-07 | Lupin Ltd | composição farmacêutica de liberação lenta de iloperidone |
| CN102108081A (zh) * | 2009-12-25 | 2011-06-29 | 重庆医药工业研究院有限责任公司 | 伊潘立酮的新晶型及其制备方法 |
| SG182285A1 (en) | 2010-01-11 | 2012-08-30 | Inotek Pharmaceuticals Corp | Combination, kit and method of reducing intraocular pressure |
| EA201290958A1 (ru) | 2010-03-26 | 2013-04-30 | Инотек Фармасьютикалз Корпорейшн | Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств |
| CN101822674B (zh) * | 2010-05-27 | 2015-03-11 | 北京德众万全医药科技有限公司 | 一种伊潘立酮药物组合物及其制备方法 |
| EP2629775A4 (en) * | 2010-10-18 | 2014-06-11 | Dainippon Sumitomo Pharma Co | INJECTABLE FORMULATION WITH DELAYED RELEASE |
| WO2012063269A2 (en) | 2010-11-12 | 2012-05-18 | Cadila Healthcare Limited | Process for preparing iloperidone |
| WO2012090138A1 (en) | 2010-12-27 | 2012-07-05 | Ranbaxy Laboratories Limited | Processes for the preparation of iloperidone |
| CN102680636A (zh) * | 2011-03-11 | 2012-09-19 | 天津药物研究院 | 一种伊潘立酮原料药及其中间体的质量控制方法 |
| KR102593047B1 (ko) | 2012-01-26 | 2023-10-24 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
| BR112014018413A8 (pt) | 2012-01-26 | 2017-07-11 | Inotek Pharmaceuticals Corp | Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo |
| US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| CN102633786B (zh) * | 2012-04-18 | 2013-11-27 | 吉林三善恩科技开发有限公司 | 一种伊潘立酮药物共晶及其制备方法 |
| CN102659771B (zh) * | 2012-04-18 | 2013-11-27 | 吉林三善恩科技开发有限公司 | 一种伊潘立酮药物共晶及其制备方法 |
| JP5959083B2 (ja) | 2012-05-18 | 2016-08-02 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | （１Ｒ−ｔｒａｎｓ）−Ｎ−［［２−（２，３−ジヒドロ−４−ベンゾフラニル）シクロプロピル］メチル］プロパンアミドの代謝物 |
| WO2014100292A1 (en) | 2012-12-18 | 2014-06-26 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| CA2903114A1 (en) | 2013-03-15 | 2014-09-25 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
| US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
| US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
| CN103599074A (zh) * | 2013-11-26 | 2014-02-26 | 重庆医药工业研究院有限责任公司 | 一种伊潘立酮缓释微球及其制备方法 |
| ES2870498T3 (es) | 2015-02-17 | 2021-10-27 | Vanda Pharmaceuticals Inc | Iloperidona para el tratamiento de esquizofrenia |
| US11071728B2 (en) | 2015-12-11 | 2021-07-27 | Vanda Pharmaceuticals Inc. | Treatment of schizophrenia |
| CN106831741B (zh) * | 2016-12-28 | 2019-08-23 | 北京医药集团有限责任公司 | 一种伊潘立酮超细粉体的制备方法 |
| US10935106B2 (en) * | 2018-06-14 | 2021-03-02 | Serapid, Inc. | Block chain with monolithic links |
| BR112021009265A2 (pt) * | 2018-12-04 | 2021-08-10 | Vanda Pharmaceuticals Inc. | métodos para preparar e administrar uma formulação de depósito injetável de iloperidona cristalina, e, formulação de depósito injetável de iloperidona cristalina |
| US20200171018A1 (en) * | 2018-12-04 | 2020-06-04 | Vanda Pharmaceuticals Inc. | Depot administration of iloperidone |
| US11607408B2 (en) | 2019-10-15 | 2023-03-21 | Vanda Pharmaceuticals Inc. | Method of treatment of schizophrenia |
| AU2023408198A1 (en) | 2022-12-19 | 2025-05-29 | Vanda Pharmaceuticals Inc. | Dosage regime of iloperidone for treating bipolar i disorder and schizophrenia |
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| BRPI0213564B8 (pt) * | 2001-10-30 | 2021-05-25 | Novartis Ag | formulação depósito e micropartícula compreendendo iloperidona e polímero poli(d,l-lactídeo-co-glicolídeo), e processo para preparação da referida micropartícula |
| GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
-
2002
- 2002-07-15 GB GBGB0216416.8A patent/GB0216416D0/en not_active Ceased
-
2003
- 2003-07-14 US US10/521,064 patent/US20050250813A1/en not_active Abandoned
- 2003-07-14 WO PCT/EP2003/007619 patent/WO2004006886A2/en not_active Ceased
- 2003-07-14 DE DE60310564T patent/DE60310564T2/de not_active Expired - Lifetime
- 2003-07-14 ES ES03756455T patent/ES2279153T3/es not_active Expired - Lifetime
- 2003-07-14 DK DK03756455T patent/DK1523335T3/da active
- 2003-07-14 AU AU2003281154A patent/AU2003281154B2/en not_active Expired
- 2003-07-14 EP EP03756455A patent/EP1523335B1/en not_active Expired - Lifetime
- 2003-07-14 PT PT03756455T patent/PT1523335E/pt unknown
- 2003-07-14 AT AT03756455T patent/ATE348635T1/de active
- 2003-07-14 JP JP2004520629A patent/JP5392961B2/ja not_active Expired - Lifetime
- 2003-07-14 CA CA2492467A patent/CA2492467C/en not_active Expired - Lifetime
- 2003-07-14 NZ NZ537598A patent/NZ537598A/en not_active IP Right Cessation
-
2004
- 2004-12-22 ZA ZA200410323A patent/ZA200410323B/en unknown
-
2006
- 2006-12-29 CY CY20061101867T patent/CY1106305T1/el unknown
-
2008
- 2008-10-21 US US12/254,925 patent/US20090099232A1/en not_active Abandoned
-
2010
- 2010-10-21 JP JP2010236087A patent/JP5670698B2/ja not_active Expired - Lifetime
-
2011
- 2011-05-12 US US13/106,417 patent/US8293765B2/en not_active Expired - Fee Related
-
2012
- 2012-02-21 US US13/401,310 patent/US8227488B2/en not_active Expired - Fee Related
- 2012-09-14 US US13/618,753 patent/US8614232B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003281154B2 (en) | 2006-10-12 |
| US8293765B2 (en) | 2012-10-23 |
| GB0216416D0 (en) | 2002-08-21 |
| WO2004006886A3 (en) | 2004-02-19 |
| DE60310564T2 (de) | 2007-10-04 |
| NZ537598A (en) | 2006-07-28 |
| JP5392961B2 (ja) | 2014-01-22 |
| PT1523335E (pt) | 2007-02-28 |
| DE60310564D1 (de) | 2007-02-01 |
| ZA200410323B (en) | 2006-06-28 |
| CA2492467A1 (en) | 2004-01-22 |
| ES2279153T3 (es) | 2007-08-16 |
| CA2492467C (en) | 2010-03-16 |
| US8614232B2 (en) | 2013-12-24 |
| AU2003281154A1 (en) | 2004-02-02 |
| US20110212141A1 (en) | 2011-09-01 |
| WO2004006886A2 (en) | 2004-01-22 |
| US20120156264A1 (en) | 2012-06-21 |
| ATE348635T1 (de) | 2007-01-15 |
| JP5670698B2 (ja) | 2015-02-18 |
| JP2011016849A (ja) | 2011-01-27 |
| EP1523335B1 (en) | 2006-12-20 |
| JP2005533093A (ja) | 2005-11-04 |
| EP1523335A2 (en) | 2005-04-20 |
| US8227488B2 (en) | 2012-07-24 |
| US20050250813A1 (en) | 2005-11-10 |
| HK1076029A1 (en) | 2006-01-06 |
| US20090099232A1 (en) | 2009-04-16 |
| US20130012542A1 (en) | 2013-01-10 |
| DK1523335T3 (da) | 2007-01-29 |
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