AR046308A1 - Derivados amida - Google Patents
Derivados amidaInfo
- Publication number
- AR046308A1 AR046308A1 ARP040103862A ARP040103862A AR046308A1 AR 046308 A1 AR046308 A1 AR 046308A1 AR P040103862 A ARP040103862 A AR P040103862A AR P040103862 A ARP040103862 A AR P040103862A AR 046308 A1 AR046308 A1 AR 046308A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- alkylamino
- amino
- halogen
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Ceramic Engineering (AREA)
- Cardiology (AREA)
- Manufacturing & Machinery (AREA)
- Pulmonology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
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- Immunology (AREA)
Abstract
Compuestos útiles para el tratamiento de enfermedades o condiciones médicas mediadas por citoquinas. Procesos para su preparación, composiciones farmacéuticas que lo contienen o sales del mismo aceptables para uso farmacéutico. Reivindicación 1: Un compuesto de la fórmula (1), caracterizado porque m es 0, 1 ó 2; R1 es halógeno, oxhidrilo, ciano, trifluorometilo, trifluorometoxi, alquilo C1-6, alcoxi C1-6, alquenilo C2-6, alquinilo C2-6, alcanoilo C2-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, hidroxialcoxi C2-6, amino-alcoxi C2-6, ciano-alcoxi C2-6, alquilamino C1-6-alcoxi C2-6, di-[alquil C1-6]amino-alcoxi C2-6, alcoxi C1-6-alcoxi C2-6, carbamoil-alcoxi C1-6, N-alquil C1-6carbamoil-alcoxi C1-6, amino-alquilo C1-6, alquilamino C1-6-alquilo C1-6, di[alquil C1-6]amino-alquilo C1-6, carbamoil-alquilo C1-6, N-alquil C1-6carbamoil-alquilo C1-6, hidroxi-alquilamino C2-6, ciano-alquilamino C2-6, halógeno-alquilamino C2-6, amino-alquilamino C2-6, alcoxi C1-6- alquilamino C2-6, alquilamino C1-6-alquilamino C2-6, di-[alquil C1-6]aminoalquilamino C2-6, heteroarilo, heteroaril-alquilo C1-6, heteroariloxi, heteroaril-alcoxi C1-6, heteroarilamino, heterociclilo, heterociclil-alquilo C1-6, heterocicliloxi, heterociclil-alcoxi C1-6 y heterociclilamino, y donde cualquier grupo arilo, heteroarilo o heterociclilo en un sustituyente R1 puede llevar opcionalmente 1 ó 2 sustituyentes que se seleccionan entre oxhidrilo, halógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-6, cicloalquil C3-6-alcoxi C1-6, alcoxi C1-6, carboxi, alcoxi C1-6carbonilo, alcoxi C1-6carbonil-alquilo C1-6, N-alquil C1-6carbamoilo, N,N-di-[alquil C1-6]carbamoilo, alcanoilo C2-6, amino, alquilamino C1-6, di-[alquil C1-6]amino, halógeno-alquilo C1-6, hidroxi-alquilo C1-6, alcoxi C1-6-alquilo C1-6, ciano-alquilo C1-6, carboxi-alquilo C1-6, amino-alquilo C1-6, alquilamino C1-6-alquilo C1-6 y di-[alquil C1-6]amino-alquilo C1-6, y donde cualquiera de los sustituyentes R1 que se definieron aquí anteriormente que comprende un grupo CH2 que está unido a 2 átomos de carbono o un grupo CH3 que está unido a un átomo de carbono o de nitrógeno puede llevar opcionalmente sobre cada uno de dichos grupos CH2 o CH3 uno o más sustituyentes que se seleccionan entre halógeno, oxhidrilo, amino, trifluorometilo, trifluorometoxi, oxo, carboxi, carbamoilo, acetamido, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, cicloalcoxi C3-6, alcoxi C1-6, alquilamino C1-6, di-[alquil C1-6]amino, hidroxi-alquilo C1-6, alcoxi C1-6-alquilo C1-6, halógeno-alquilo C1-6, alcoxi C1-6-alcoxi C2-6, alcoxi C1-6carbonilo, carbamoilo, N-alquil C1-6carbamoilo, N,N-di-[alquil C1- 6]carbamoilo, sulfonilo C1-6, sulfamoilo C1-6, heteroarilo, heteroaril-alquilo C1-6, heterociclilo y heterocicliloxi, y donde cualquier grupo heterociclilo en un sustituyente R1 puede llevar opcionalmente 1 ó 2 sustituyentes oxo o tioxo; R2 es halógeno, trifluorometilo o alquilo C1-6; R3 es hidrógeno, halógeno o alquilo C1-6; y R4 es cicloalquilo C3-6, y R4 opcionalmente puede estar sustituido con uno o más sustituyentes que se seleccionan entre halógeno, oxhidrilo, amino, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, alquilamino C1-6 y di-[alquil C1-6]amino; o una sal del mismo aceptable para uso farmacéutico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0324790.5A GB0324790D0 (en) | 2003-10-24 | 2003-10-24 | Amide derivatives |
Publications (1)
Publication Number | Publication Date |
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AR046308A1 true AR046308A1 (es) | 2005-11-30 |
Family
ID=29595715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP040103862A AR046308A1 (es) | 2003-10-24 | 2004-10-22 | Derivados amida |
Country Status (28)
Country | Link |
---|---|
US (1) | US7750154B2 (es) |
EP (1) | EP1682520B1 (es) |
JP (1) | JP4987478B2 (es) |
KR (1) | KR101127697B1 (es) |
CN (2) | CN1898216A (es) |
AR (1) | AR046308A1 (es) |
AT (1) | ATE499347T1 (es) |
AU (1) | AU2004285749B2 (es) |
BR (1) | BRPI0415746A (es) |
CA (1) | CA2543351C (es) |
DE (1) | DE602004031543D1 (es) |
ES (1) | ES2359409T3 (es) |
GB (1) | GB0324790D0 (es) |
HK (1) | HK1091830A1 (es) |
IL (1) | IL175065A (es) |
IS (1) | IS8450A (es) |
MX (1) | MXPA06004465A (es) |
MY (1) | MY140729A (es) |
NO (1) | NO20062370L (es) |
NZ (1) | NZ547095A (es) |
RU (1) | RU2375352C2 (es) |
SA (1) | SA04250351B1 (es) |
SG (1) | SG147409A1 (es) |
TW (1) | TWI343378B (es) |
UA (1) | UA83867C2 (es) |
UY (1) | UY28578A1 (es) |
WO (1) | WO2005042502A1 (es) |
ZA (1) | ZA200603226B (es) |
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2003
- 2003-10-24 GB GBGB0324790.5A patent/GB0324790D0/en not_active Ceased
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2004
- 2004-10-21 TW TW093132022A patent/TWI343378B/zh not_active IP Right Cessation
- 2004-10-22 AU AU2004285749A patent/AU2004285749B2/en not_active Ceased
- 2004-10-22 DE DE602004031543T patent/DE602004031543D1/de active Active
- 2004-10-22 KR KR1020067010003A patent/KR101127697B1/ko not_active IP Right Cessation
- 2004-10-22 WO PCT/GB2004/004474 patent/WO2005042502A1/en active Application Filing
- 2004-10-22 MX MXPA06004465A patent/MXPA06004465A/es active IP Right Grant
- 2004-10-22 AT AT04768990T patent/ATE499347T1/de not_active IP Right Cessation
- 2004-10-22 MY MYPI20044370A patent/MY140729A/en unknown
- 2004-10-22 NZ NZ547095A patent/NZ547095A/en not_active IP Right Cessation
- 2004-10-22 ES ES04768990T patent/ES2359409T3/es active Active
- 2004-10-22 RU RU2006117326/04A patent/RU2375352C2/ru not_active IP Right Cessation
- 2004-10-22 UA UAA200604496A patent/UA83867C2/ru unknown
- 2004-10-22 JP JP2006536171A patent/JP4987478B2/ja not_active Expired - Fee Related
- 2004-10-22 BR BRPI0415746-0A patent/BRPI0415746A/pt not_active IP Right Cessation
- 2004-10-22 SG SG200807338-9A patent/SG147409A1/en unknown
- 2004-10-22 CA CA2543351A patent/CA2543351C/en not_active Expired - Fee Related
- 2004-10-22 CN CNA2004800390365A patent/CN1898216A/zh active Pending
- 2004-10-22 UY UY28578A patent/UY28578A1/es not_active Application Discontinuation
- 2004-10-22 EP EP04768990A patent/EP1682520B1/en active Active
- 2004-10-22 CN CN2012103938753A patent/CN103012376A/zh active Pending
- 2004-10-22 US US10/576,808 patent/US7750154B2/en not_active Expired - Fee Related
- 2004-10-22 AR ARP040103862A patent/AR046308A1/es not_active Application Discontinuation
- 2004-10-23 SA SA04250351A patent/SA04250351B1/ar unknown
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2006
- 2006-04-20 IL IL175065A patent/IL175065A/en not_active IP Right Cessation
- 2006-04-21 ZA ZA200603226A patent/ZA200603226B/en unknown
- 2006-05-11 IS IS8450A patent/IS8450A/is unknown
- 2006-05-24 NO NO20062370A patent/NO20062370L/no not_active Application Discontinuation
- 2006-11-10 HK HK06112435.2A patent/HK1091830A1/xx not_active IP Right Cessation
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