CU24316B1 - Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen - Google Patents

Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen

Info

Publication number
CU24316B1
CU24316B1 CUP2014000095A CU20140095A CU24316B1 CU 24316 B1 CU24316 B1 CU 24316B1 CU P2014000095 A CUP2014000095 A CU P2014000095A CU 20140095 A CU20140095 A CU 20140095A CU 24316 B1 CU24316 B1 CU 24316B1
Authority
CU
Cuba
Prior art keywords
formula
compounds
preparation
tetraisoquinolina
phyphate
Prior art date
Application number
CUP2014000095A
Other languages
English (en)
Spanish (es)
Other versions
CU20140095A7 (es
Inventor
I Jen Chen
James Edward Paul Davidson
Nanteuil Guillaume De
Olivier Geneste
Anne Françoise Guillouzic
Jean Michel Henlin
Diguarher Thierry Le
Tiran Arnaud Le
James Brooke Murray
Jerome Benoît Starck
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50288170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24316(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of CU20140095A7 publication Critical patent/CU20140095A7/es
Publication of CU24316B1 publication Critical patent/CU24316B1/xx

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092Details
    • A61N2005/1098Enhancing the effect of the particle by an injected agent or implanted device

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CUP2014000095A 2013-07-23 2014-07-23 Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen CU24316B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1357259A FR3008979B1 (fr) 2013-07-23 2013-07-23 Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CU20140095A7 CU20140095A7 (es) 2016-02-29
CU24316B1 true CU24316B1 (es) 2018-02-08

Family

ID=50288170

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2014000095A CU24316B1 (es) 2013-07-23 2014-07-23 Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen

Country Status (48)

Country Link
US (3) US9115159B2 (pl)
EP (1) EP2829545B1 (pl)
JP (1) JP5894638B2 (pl)
KR (2) KR101713103B1 (pl)
CN (1) CN104341451B (pl)
AP (1) AP2014007773A0 (pl)
AR (1) AR097008A1 (pl)
AU (1) AU2014203808B2 (pl)
BR (1) BR102014017997B1 (pl)
CA (1) CA2856886C (pl)
CL (1) CL2014001865A1 (pl)
CR (1) CR20140336A (pl)
CU (1) CU24316B1 (pl)
CY (1) CY1117834T1 (pl)
DK (1) DK2829545T3 (pl)
DO (1) DOP2014000163A (pl)
EA (1) EA027444B1 (pl)
EC (1) ECSP14008757A (pl)
ES (1) ES2593417T3 (pl)
FR (1) FR3008979B1 (pl)
GE (1) GEP201706704B (pl)
HK (1) HK1204623A1 (pl)
HR (1) HRP20161202T8 (pl)
HU (1) HUE029616T2 (pl)
IL (1) IL233580B (pl)
JO (1) JO3160B1 (pl)
MA (1) MA37213B1 (pl)
MD (1) MD4551C1 (pl)
ME (1) ME02641B (pl)
MX (1) MX351467B (pl)
MY (1) MY173258A (pl)
NI (1) NI201400080A (pl)
PE (1) PE20150218A1 (pl)
PH (1) PH12014000194B1 (pl)
PL (1) PL2829545T3 (pl)
PT (1) PT2829545T (pl)
RS (1) RS55098B1 (pl)
RU (1) RU2617682C2 (pl)
SA (1) SA114350669B1 (pl)
SG (1) SG10201403939WA (pl)
SI (1) SI2829545T1 (pl)
SV (1) SV2014004771A (pl)
TN (1) TN2014000301A1 (pl)
TW (1) TWI527824B (pl)
UA (1) UA119738C2 (pl)
UY (1) UY35661A (pl)
WO (1) WO2015011399A1 (pl)
ZA (1) ZA201405418B (pl)

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FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008977A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY37316A (es) * 2016-07-07 2018-01-31 Servier Lab Dispersión sólida farmacéutica de un inhibidor de bcl-2, composiciones farmacéuticas de ésta, y usos para el tratamiento de cáncer
WO2018015526A1 (en) 2016-07-22 2018-01-25 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mcl-1 inhibitor, uses and pharmaceutical compositions thereof
KR102505218B1 (ko) * 2016-07-22 2023-02-28 르 라보레또레 쎄르비에르 BCL-2 억제제와 MCl-1 억제제의 조합물, 이의 용도 및 약학적 조성물
WO2018158225A1 (en) 2017-02-28 2018-09-07 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof
EA039621B1 (ru) * 2017-06-09 2022-02-17 Ле Лаборатуар Сервье Комбинация bcl-2 ингибитора и mcl-1 ингибитора, их применения и фармацевтические композиции
AR112440A1 (es) * 2017-07-06 2019-10-30 Servier Lab Forma cristalina de un inhibidor de bcl-2, un proceso para su preparación y composiciones farmacéuticas que la contienen
FR3072679B1 (fr) * 2017-10-25 2020-10-30 Servier Lab Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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PT4013412T (pt) 2019-08-12 2026-03-18 Deciphera Pharmaceuticals Llc Ripretinib para o tratamento de tumores estromais gastrointestinais
CN110606860B (zh) 2019-09-29 2021-12-10 上海勋和医药科技有限公司 一种吡啶磺酰胺磷酸酯类化合物、其制备方法及其用途
HRP20231699T1 (hr) 2019-12-30 2024-05-10 Deciphera Pharmaceuticals, Llc Formulacije inhibitora amorfne kinaze i postupci njihove primjene
CN115243681B (zh) 2019-12-30 2024-08-16 德西费拉制药有限责任公司 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物
AR125076A1 (es) * 2021-03-12 2023-06-07 Eil Therapeutics Inc Compuestos que tienen tetrahidroindolizina-1-carboxamida como inhibidores de bcl-2
US20250002491A1 (en) 2021-10-04 2025-01-02 Forx Therapeutics Ag N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
CN120787162A (zh) 2022-05-20 2025-10-14 诺华股份有限公司 抗肿瘤化合物的抗体-药物缀合物及其使用方法
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Publication number Publication date
TW201504254A (zh) 2015-02-01
EP2829545A1 (fr) 2015-01-28
IL233580A0 (en) 2014-11-02
DOP2014000163A (es) 2015-01-15
JP2015028017A (ja) 2015-02-12
PT2829545T (pt) 2016-07-13
PL2829545T3 (pl) 2016-12-30
EA201400754A2 (ru) 2014-12-30
FR3008979A1 (fr) 2015-01-30
PE20150218A1 (es) 2015-02-14
CA2856886A1 (fr) 2015-01-23
US20150031648A1 (en) 2015-01-29
DK2829545T3 (en) 2016-09-19
BR102014017997A2 (pt) 2015-11-17
TWI527824B (zh) 2016-04-01
GEP201706704B (en) 2017-07-25
FR3008979B1 (fr) 2015-07-24
US9597341B2 (en) 2017-03-21
ECSP14008757A (es) 2016-01-29
HUE029616T2 (en) 2017-03-28
AR097008A1 (es) 2016-02-10
HRP20161202T8 (hr) 2016-12-30
MD4551B1 (ro) 2018-02-28
SG10201403939WA (en) 2015-02-27
MX351467B (es) 2017-10-17
RS55098B1 (sr) 2016-12-30
US20170143746A1 (en) 2017-05-25
BR102014017997B1 (pt) 2020-05-19
ES2593417T3 (es) 2016-12-09
PH12014000194A1 (en) 2015-06-29
MY173258A (en) 2020-01-09
HK1201536A1 (zh) 2015-09-04
US20150313923A1 (en) 2015-11-05
SV2014004771A (es) 2015-01-28
UA119738C2 (uk) 2019-08-12
IL233580B (en) 2020-03-31
CY1117834T1 (el) 2017-05-17
KR101713103B1 (ko) 2017-03-07
JO3160B1 (ar) 2017-09-20
AU2014203808A1 (en) 2015-02-12
UY35661A (es) 2015-02-27
US9115159B2 (en) 2015-08-25
WO2015011399A1 (fr) 2015-01-29
TN2014000301A1 (fr) 2015-12-21
PH12014000194B1 (en) 2015-06-29
HK1204623A1 (en) 2015-11-27
KR20150011785A (ko) 2015-02-02
MD4551C1 (ro) 2018-09-30
NI201400080A (es) 2014-10-24
MX2014008866A (es) 2015-07-21
CU20140095A7 (es) 2016-02-29
RU2617682C2 (ru) 2017-04-26
ZA201405418B (en) 2020-02-26
JP5894638B2 (ja) 2016-03-30
SA114350669B1 (ar) 2016-04-11
MD20140073A2 (en) 2015-01-31
EA201400754A3 (ru) 2015-03-31
EP2829545B1 (fr) 2016-06-22
CL2014001865A1 (es) 2015-06-26
MA37213B1 (fr) 2017-03-31
CN104341451A (zh) 2015-02-11
SI2829545T1 (sl) 2016-10-28
MA37213A1 (fr) 2016-06-30
KR20170001694A (ko) 2017-01-04
HRP20161202T1 (hr) 2016-11-04
EA027444B1 (ru) 2017-07-31
CR20140336A (es) 2015-10-07
AP2014007773A0 (en) 2014-07-31
ME02641B (me) 2017-06-20
NZ627178A (en) 2016-01-29
CA2856886C (fr) 2016-08-02
CN104341451B (zh) 2018-04-03
AU2014203808B2 (en) 2018-09-20
RU2014130129A (ru) 2016-02-10

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