CS600884A2 - Zpusob pripravy krystalcke formy (4,5,6r,8r) methyl 9 oxo 11 alfa, 15 alfa dihydroxy 16fenoxy 17,1g,19, 20 tetranorprosta 4,5,13(e) trienoatu - Google Patents

Zpusob pripravy krystalcke formy (4,5,6r,8r) methyl 9 oxo 11 alfa, 15 alfa dihydroxy 16fenoxy 17,1g,19, 20 tetranorprosta 4,5,13(e) trienoatu

Info

Publication number
CS600884A2
CS600884A2 CS866008A CS600884A CS600884A2 CS 600884 A2 CS600884 A2 CS 600884A2 CS 866008 A CS866008 A CS 866008A CS 600884 A CS600884 A CS 600884A CS 600884 A2 CS600884 A2 CS 600884A2
Authority
CS
Czechoslovakia
Prior art keywords
alfa
trienoatu
krystalcke
16fenoxy
tetranorprosta
Prior art date
Application number
CS866008A
Other languages
Czech (cs)
English (en)
Inventor
Gary F Cooper
Duoglas L Wren
Horn Albert R Van
Tsung Tee Li
Colin Ch Beard
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of CS600884A2 publication Critical patent/CS600884A2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS866008A 1983-12-22 1984-12-20 Zpusob pripravy krystalcke formy (4,5,6r,8r) methyl 9 oxo 11 alfa, 15 alfa dihydroxy 16fenoxy 17,1g,19, 20 tetranorprosta 4,5,13(e) trienoatu CS600884A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/564,386 US4600785A (en) 1983-12-22 1983-12-22 Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Publications (1)

Publication Number Publication Date
CS600884A2 true CS600884A2 (en) 1987-09-17

Family

ID=24254259

Family Applications (5)

Application Number Title Priority Date Filing Date
CS866008A CS600884A2 (en) 1983-12-22 1984-12-20 Zpusob pripravy krystalcke formy (4,5,6r,8r) methyl 9 oxo 11 alfa, 15 alfa dihydroxy 16fenoxy 17,1g,19, 20 tetranorprosta 4,5,13(e) trienoatu
CS866007A CS600784A2 (en) 1983-12-22 1984-12-20 Zpusob vyroby derivatu kyseliny 16 fenoxyprostatrienove
CS8410132A CS257784B2 (en) 1983-12-22 1984-12-20 Method of 16-phenoxy prostathrienic acid's derivatives production
CS866007A CS257796B2 (en) 1983-12-22 1986-08-14 Method of 16-phenoxyprostatrienic acid's derivatives production
CS866008A CS257797B2 (en) 1983-12-22 1986-08-14 Method of (4,5,6r,8r)-methyl-9-oxo-11 alpha,15 alpha-dihydroxy-16 phenoxy-17,18,19,20-tetranorprosta-4,5,13(e)-trienoat's crystalline form preparation

Family Applications After (4)

Application Number Title Priority Date Filing Date
CS866007A CS600784A2 (en) 1983-12-22 1984-12-20 Zpusob vyroby derivatu kyseliny 16 fenoxyprostatrienove
CS8410132A CS257784B2 (en) 1983-12-22 1984-12-20 Method of 16-phenoxy prostathrienic acid's derivatives production
CS866007A CS257796B2 (en) 1983-12-22 1986-08-14 Method of 16-phenoxyprostatrienic acid's derivatives production
CS866008A CS257797B2 (en) 1983-12-22 1986-08-14 Method of (4,5,6r,8r)-methyl-9-oxo-11 alpha,15 alpha-dihydroxy-16 phenoxy-17,18,19,20-tetranorprosta-4,5,13(e)-trienoat's crystalline form preparation

Country Status (28)

Country Link
US (1) US4600785A (es)
EP (1) EP0146935B1 (es)
JP (3) JPH0635431B2 (es)
KR (1) KR900000684B1 (es)
CN (1) CN85101840A (es)
AR (1) AR241015A1 (es)
AT (1) ATE50986T1 (es)
AU (1) AU585844B2 (es)
CA (4) CA1267892A (es)
CS (5) CS600884A2 (es)
DD (2) DD241254A5 (es)
DE (1) DE3481610D1 (es)
DK (1) DK617084A (es)
ES (4) ES8604389A1 (es)
FI (1) FI845069L (es)
GR (1) GR82514B (es)
HU (2) HU196732B (es)
IL (1) IL73881A (es)
IN (1) IN160437B (es)
MX (2) MX158754A (es)
NO (1) NO845148L (es)
NZ (1) NZ210667A (es)
PH (2) PH22893A (es)
PL (2) PL154330B1 (es)
PT (1) PT79720A (es)
RO (2) RO91666B (es)
SU (3) SU1473709A3 (es)
ZA (1) ZA849967B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO163485C (no) * 1984-10-09 1990-06-06 Syntex Inc Mellomprodukter for fremstilling av 16-fenoksy- og 16-substituerte fenoksy-prostatriensyrederivater og fremgangsmaate ved fremstilling av mellomproduktene.
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4778904A (en) * 1985-09-13 1988-10-18 Syntex (U.S.A.) Inc. Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US4689419A (en) * 1986-11-14 1987-08-25 G. D. Searle & Co. Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives
US5248788A (en) * 1988-12-13 1993-09-28 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US4916238A (en) * 1988-12-13 1990-04-10 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US5571936A (en) * 1994-09-30 1996-11-05 Korea Institute Of Science And Technology Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304907A (en) * 1972-05-10 1981-12-08 The Upjohn Company Bicyclo lactone intermediates for prostaglandin analogs
JPS5434724B2 (es) * 1974-09-19 1979-10-29
GB1590022A (en) * 1976-08-23 1981-05-28 Ono Pharmaceutical Co Prostaglandin analogues
US4178457A (en) * 1978-07-10 1979-12-11 Syntex (U.S.A.) Inc. (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
DE3030477C2 (de) * 1980-08-12 1986-10-16 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe Iridoid-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung
US4389414A (en) * 1981-05-11 1983-06-21 Syntex (U.S.A.) Inc. Prostaglandin compositions
CA1216793A (en) * 1982-07-19 1987-01-20 Cheng-Der Yu Pge-type compositions encapsulated by acid isolated gelatin
US4618696A (en) * 1984-07-31 1986-10-21 Syntex (U.S.A.) Inc. 9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates
NZ212914A (en) * 1984-07-31 1988-08-30 Syntex Inc Tetranorprostaglandin derivatives and pharmaceutical compositions
NO163485C (no) * 1984-10-09 1990-06-06 Syntex Inc Mellomprodukter for fremstilling av 16-fenoksy- og 16-substituerte fenoksy-prostatriensyrederivater og fremgangsmaate ved fremstilling av mellomproduktene.

Also Published As

Publication number Publication date
CS1013284A2 (en) 1987-09-17
ES548460A0 (es) 1986-06-01
ES548453A0 (es) 1986-06-01
EP0146935A2 (en) 1985-07-03
ES548459A0 (es) 1986-08-01
ZA849967B (en) 1986-08-27
US4600785A (en) 1986-07-15
AU585844B2 (en) 1989-06-29
RO91666B (ro) 1987-07-31
AR241015A1 (es) 1991-04-30
EP0146935A3 (en) 1987-05-06
ES538899A0 (es) 1986-02-01
JPH0539263A (ja) 1993-02-19
MX158754A (es) 1989-03-10
PL154330B1 (en) 1991-08-30
PH22893A (en) 1989-01-19
KR850004589A (ko) 1985-07-25
IL73881A (en) 1990-01-18
FI845069A0 (fi) 1984-12-20
GR82514B (en) 1985-04-11
CS257797B2 (en) 1988-06-15
JPH0539262A (ja) 1993-02-19
SU1342411A3 (ru) 1987-09-30
ATE50986T1 (de) 1990-03-15
AR241015A2 (es) 1991-04-30
PL255723A1 (en) 1986-07-29
FI845069L (fi) 1985-06-23
DK617084D0 (da) 1984-12-20
JPH0717597B2 (ja) 1995-03-01
CA1283408C (en) 1991-04-23
DK617084A (da) 1985-06-23
IN160437B (es) 1987-07-11
KR900000684B1 (ko) 1990-02-03
CA1276931C (en) 1990-11-27
NO845148L (no) 1985-06-24
JPH0772170B2 (ja) 1995-08-02
MX12599A (es) 1993-05-01
RO91666A (ro) 1987-07-30
PT79720A (en) 1985-01-01
DE3481610D1 (de) 1990-04-19
SU1473709A3 (ru) 1989-04-15
HU196732B (en) 1989-01-30
CS257784B2 (en) 1988-06-15
CA1267892A (en) 1990-04-17
ES8609234A1 (es) 1986-08-01
ES8607228A1 (es) 1986-06-01
AU3712084A (en) 1985-07-04
NZ210667A (en) 1988-08-30
EP0146935B1 (en) 1990-03-14
JPH0635431B2 (ja) 1994-05-11
DD241254A5 (de) 1986-12-03
IL73881A0 (en) 1985-03-31
CA1283409C (en) 1991-04-23
HU197302B (en) 1989-03-28
CS600784A2 (en) 1987-09-17
PH23728A (en) 1989-11-03
HUT36090A (en) 1985-08-28
CN85101840A (zh) 1987-01-17
ES8604389A1 (es) 1986-02-01
JPS60169459A (ja) 1985-09-02
SU1356959A3 (ru) 1987-11-30
DD249700A5 (de) 1987-09-16
RO94561A7 (ro) 1988-06-30
CS257796B2 (en) 1988-06-15
ES8607229A1 (es) 1986-06-01
PL251088A1 (en) 1985-12-17

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