CS276849B6 - Process for preparing heat stable crystalline mono chloride - Google Patents

Process for preparing heat stable crystalline mono chloride Download PDF

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Publication number
CS276849B6
CS276849B6 CS903570A CS357086A CS276849B6 CS 276849 B6 CS276849 B6 CS 276849B6 CS 903570 A CS903570 A CS 903570A CS 357086 A CS357086 A CS 357086A CS 276849 B6 CS276849 B6 CS 276849B6
Authority
CS
Czechoslovakia
Prior art keywords
methyl
carboxylate
aminothiazol
preparation
monohydrochloride
Prior art date
Application number
CS903570A
Other languages
Czech (cs)
English (en)
Inventor
Murray A Kaplan
Thomas W Hudyma
Robert A Lipper
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CS276849B6 publication Critical patent/CS276849B6/cs

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
CS903570A 1985-08-05 1986-08-04 Process for preparing heat stable crystalline mono chloride CS276849B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05

Publications (1)

Publication Number Publication Date
CS276849B6 true CS276849B6 (en) 1992-08-12

Family

ID=25064475

Family Applications (2)

Application Number Title Priority Date Filing Date
CS903570A CS276849B6 (en) 1985-08-05 1986-08-04 Process for preparing heat stable crystalline mono chloride
CS865827A CS276717B6 (en) 1985-08-05 1986-08-04 Process for preparing heat stable crystalline addition salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS865827A CS276717B6 (en) 1985-08-05 1986-08-04 Process for preparing heat stable crystalline addition salts

Country Status (34)

Country Link
JP (1) JPH0615548B2 (it)
KR (1) KR930003121B1 (it)
AR (1) AR243894A1 (it)
AT (1) AT390957B (it)
AU (1) AU597262B2 (it)
BE (1) BE905219A (it)
CA (1) CA1284994C (it)
CH (1) CH675581A5 (it)
CS (2) CS276849B6 (it)
CY (1) CY1614A (it)
DD (2) DD254941A5 (it)
DE (1) DE3626375A1 (it)
DK (1) DK162053C (it)
EG (1) EG18003A (it)
ES (1) ES2002112A6 (it)
FI (1) FI84484C (it)
FR (1) FR2585705B1 (it)
GB (1) GB2179936B (it)
GR (1) GR862055B (it)
HK (1) HK99691A (it)
HU (1) HU196602B (it)
IE (1) IE59222B1 (it)
IL (1) IL79608A (it)
IT (1) IT1197067B (it)
LU (2) LU88574I2 (it)
MY (1) MY102212A (it)
NL (1) NL8601991A (it)
OA (1) OA08672A (it)
PT (1) PT83134B (it)
SE (1) SE469633B (it)
SG (1) SG79791G (it)
SU (1) SU1516013A3 (it)
YU (1) YU45793B (it)
ZA (1) ZA865842B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
DE3788279T2 (de) * 1987-06-25 1994-06-16 Banyu Pharma Co Ltd Kristalline cephalosporinzusammensetzungen, verfahren und zwischenprodukte für ihre herstellung.
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
US7592447B2 (en) 2003-12-23 2009-09-22 Sandoz Ag Process for production of intermediates for use in cefalosporin synthesis
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
HUT41802A (en) 1987-05-28
GB8618989D0 (en) 1986-09-17
AU597262B2 (en) 1990-05-31
SE469633B (sv) 1993-08-09
DD254941A5 (de) 1988-03-16
FI84484C (fi) 1991-12-10
LU86540A1 (fr) 1987-03-06
FR2585705B1 (fr) 1989-01-13
DK371886D0 (da) 1986-08-04
PT83134B (pt) 1989-07-31
MY102212A (en) 1992-05-15
AT390957B (de) 1990-07-25
IT1197067B (it) 1988-11-25
GB2179936A (en) 1987-03-18
ES2002112A6 (es) 1988-07-16
SE8603308D0 (sv) 1986-08-04
HK99691A (en) 1991-12-13
LU88574I2 (fr) 1995-03-01
KR930003121B1 (ko) 1993-04-19
SE8603308L (sv) 1987-02-06
DK371886A (da) 1987-02-06
DK162053C (da) 1992-02-10
CH675581A5 (it) 1990-10-15
EG18003A (en) 1991-08-30
ATA211086A (de) 1990-01-15
JPS62103090A (ja) 1987-05-13
YU137186A (en) 1987-12-31
AU6069486A (en) 1987-02-12
IE862078L (en) 1987-02-05
IT8621409A0 (it) 1986-08-04
SG79791G (en) 1991-11-15
IE59222B1 (en) 1994-01-26
SU1516013A3 (ru) 1989-10-15
FR2585705A1 (fr) 1987-02-06
BE905219A (fr) 1987-02-04
ZA865842B (en) 1987-04-29
AR243894A1 (es) 1993-09-30
FI84484B (fi) 1991-08-30
IL79608A (en) 1991-07-18
HU196602B (en) 1988-12-28
DE3626375A1 (de) 1987-02-12
NL8601991A (nl) 1987-03-02
IT8621409A1 (it) 1988-02-04
PT83134A (en) 1986-09-01
DK162053B (da) 1991-09-09
CA1284994C (en) 1991-06-18
CS276717B6 (en) 1992-08-12
OA08672A (en) 1989-03-31
IL79608A0 (en) 1986-11-30
CY1614A (en) 1992-07-10
FI863155A0 (fi) 1986-08-01
GR862055B (en) 1986-12-24
GB2179936B (en) 1989-04-26
JPH0615548B2 (ja) 1994-03-02
KR880002530A (ko) 1988-05-09
DD268395A5 (de) 1989-05-31
YU45793B (sh) 1992-07-20
FI863155A (fi) 1987-02-06

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