CS273172B2 - Method of dihydropyridine derivatives production - Google Patents

Method of dihydropyridine derivatives production Download PDF

Info

Publication number
CS273172B2
CS273172B2 CS91186A CS91186A CS273172B2 CS 273172 B2 CS273172 B2 CS 273172B2 CS 91186 A CS91186 A CS 91186A CS 91186 A CS91186 A CS 91186A CS 273172 B2 CS273172 B2 CS 273172B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
group
phenylene
phenyl
carbon atoms
Prior art date
Application number
CS91186A
Other languages
Czech (cs)
English (en)
Other versions
CS91186A2 (en
Inventor
Rodney B Hargreaves
Bernard J Mcloughlin
Stuart D Mills
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Priority to CS334987A priority Critical patent/CS273180B2/cs
Publication of CS91186A2 publication Critical patent/CS91186A2/cs
Publication of CS273172B2 publication Critical patent/CS273172B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS91186A 1985-02-11 1986-02-10 Method of dihydropyridine derivatives production CS273172B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS334987A CS273180B2 (en) 1985-02-11 1987-05-11 Method of dihydropyridine derivatives production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858503425A GB8503425D0 (en) 1985-02-11 1985-02-11 Alkanolamine derivatives

Publications (2)

Publication Number Publication Date
CS91186A2 CS91186A2 (en) 1990-07-12
CS273172B2 true CS273172B2 (en) 1991-03-12

Family

ID=10574270

Family Applications (1)

Application Number Title Priority Date Filing Date
CS91186A CS273172B2 (en) 1985-02-11 1986-02-10 Method of dihydropyridine derivatives production

Country Status (21)

Country Link
US (1) US4873254A (el)
EP (1) EP0194751B1 (el)
JP (1) JPH0819100B2 (el)
KR (1) KR860006443A (el)
AU (1) AU5339486A (el)
CS (1) CS273172B2 (el)
DD (1) DD250533A5 (el)
DE (1) DE3684803D1 (el)
DK (1) DK66186A (el)
ES (2) ES8802139A1 (el)
FI (1) FI860621A (el)
GB (2) GB8503425D0 (el)
GR (1) GR860369B (el)
HU (1) HU196179B (el)
NO (1) NO860465L (el)
NZ (1) NZ215083A (el)
PH (1) PH22683A (el)
PL (2) PL149828B1 (el)
PT (1) PT82008B (el)
SU (1) SU1590041A3 (el)
ZA (1) ZA86967B (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6112662A (ja) * 1984-06-28 1986-01-21 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体及びその製法
US4782160A (en) * 1986-12-08 1988-11-01 Yamanouchi Pharmaceutical Co., Ltd. 1,4-dihydropyridine derivatives
GB9102031D0 (en) * 1991-01-30 1991-03-13 Fujisawa Pharmaceutical Co Dihydropyridine compounds,and process for their preparation
AU8430098A (en) * 1998-07-23 2000-02-14 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity
CA2704199C (en) 2007-11-01 2016-01-19 Acucela Inc. Amine derivative compounds for treating ophthalmic diseases and disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4500527A (en) * 1983-06-22 1985-02-19 Usv Pharmaceutical Corporation Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl phenyl]-1,4-dihydropyridines
JPS6112662A (ja) * 1984-06-28 1986-01-21 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体及びその製法

Also Published As

Publication number Publication date
KR860006443A (ko) 1986-09-11
US4873254A (en) 1989-10-10
GB8602704D0 (en) 1986-03-12
JPH0819100B2 (ja) 1996-02-28
PT82008B (pt) 1988-07-01
ES8802496A1 (es) 1988-07-01
NZ215083A (en) 1989-10-27
ES557630A0 (es) 1988-07-01
ES551844A0 (es) 1988-04-01
AU5339486A (en) 1986-08-14
ZA86967B (en) 1986-11-26
HUT40415A (en) 1986-12-28
PL153857B1 (en) 1991-06-28
GR860369B (en) 1986-06-02
EP0194751B1 (en) 1992-04-15
PL265252A1 (en) 1988-06-09
DK66186D0 (da) 1986-02-11
CS91186A2 (en) 1990-07-12
PT82008A (en) 1986-03-01
ES8802139A1 (es) 1988-04-01
HU196179B (en) 1988-10-28
DE3684803D1 (de) 1992-05-21
NO860465L (no) 1986-08-12
FI860621A (fi) 1986-08-12
DK66186A (da) 1986-08-12
JPS61233669A (ja) 1986-10-17
PL257902A1 (en) 1988-03-03
GB8503425D0 (en) 1985-03-13
DD250533A5 (de) 1987-10-14
FI860621A0 (fi) 1986-02-11
PL149828B1 (en) 1990-03-31
PH22683A (en) 1988-11-14
SU1590041A3 (ru) 1990-08-30
EP0194751A1 (en) 1986-09-17

Similar Documents

Publication Publication Date Title
EP0094159B1 (en) Dihydropyridine derivatives, their production and use
US4656181A (en) Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
EP0126449B1 (en) Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry
KR880000180B1 (ko) 디하이드로 피리딘의 제조방법
RU2091379C1 (ru) Дифенилметилпиперазиновые производные или их фармацевтически приемлемая соль
FR2562892A1 (fr) Nouveaux dihydropyridinyldicarboxylates amides et esters, utilisation de ces composes comme medicament, compositions pharmaceutiques comprenant de tels composes et procede pour la preparation de tels composes
WO1986004581A1 (en) Dihydropyridine alkanolamines
US8063093B2 (en) Potassium channel blockers and uses thereof
KR960009427B1 (ko) 1,4-디히드로피리딘 유도체, 그의 약학적 조성물 및 그 제조방법
CS273172B2 (en) Method of dihydropyridine derivatives production
JPS6256474A (ja) ジヒドロピリジン−２−ヒドロキシアミン類
CS273180B2 (en) Method of dihydropyridine derivatives production
JPS62226960A (ja) 単環式エステル、その製法及びこのエステルを含有する、高血圧、冠状心臓病、末梢及び脳循環障害及び／又は高められた水−又はナトリウム貯留に帰因する疾患を治療及び予防するための医薬
EP0194752A1 (en) Dihydropyridine alkanol amines, process for their preparation and pharmaceutical compositions containing them
JPS5916876A (ja) カルシウムに拮抗する塩基性エステル、その製造法およびそれを有効成分とする医薬
NO860464L (no) Fremgangsmaate for fremstilling av farmasoeytisk aktive dihydropyridinderivater.
FR2502619A1 (fr) Derives de la 1(2h)-isoquinolone et leurs utilisations therapeutiques notamment dans le traitement des ulceres
JP3514784B2 (ja) アリールアミド誘導体
JPH07215965A (ja) インドールスルホンアミド−置換ジヒドロピリジン類
EP0194047A1 (en) Dihydropyridine alkanol amines, process for their preparation and pharmaceutical compositions containing them
JPS61137861A (ja) １，４−ジヒドロピリジン−ヒドロキシアミン類
JPH02138257A (ja) １，４―ジヒドロピリジン化合物
KR820001544B1 (ko) 치환된 n-이미노 메틸피페리딘의 제조방법
KR820001447B1 (ko) 3-인돌릴-3급 부틸아미노프로판올의 제조방법
JPH05504778A (ja) 新規３（２ｈ）―ピリダジノン、それを含む医薬組成物及びその調製方法