CS271474B2 - Method of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine preparation - Google Patents

Method of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine preparation Download PDF

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Publication number
CS271474B2
CS271474B2 CS875275A CS527587A CS271474B2 CS 271474 B2 CS271474 B2 CS 271474B2 CS 875275 A CS875275 A CS 875275A CS 527587 A CS527587 A CS 527587A CS 271474 B2 CS271474 B2 CS 271474B2
Authority
CS
Czechoslovakia
Prior art keywords
piperidine
dihydro
imino
amino
piperidinopyrimidine
Prior art date
Application number
CS875275A
Other languages
Czech (cs)
English (en)
Other versions
CS527587A2 (en
Inventor
Andras Dr Vedres
Csaba Dr Szantay
Bela Dr Stefko
Janos Dr Kreidl
Andras Dr Nemes
Gabor Dr Blasko
Erik Bossch
Denes Mathe
Istvan Hegedus
Adrienn Dr Szuchovszky
Tamas Mester
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of CS527587A2 publication Critical patent/CS527587A2/cs
Publication of CS271474B2 publication Critical patent/CS271474B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CS875275A 1986-07-10 1987-07-10 Method of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine preparation CS271474B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862855A HU196067B (en) 1986-07-10 1986-07-10 Process for production of 6-amin-1,2-dihydro-1-hydroxi-2-imino-4-piperidin-piramidin

Publications (2)

Publication Number Publication Date
CS527587A2 CS527587A2 (en) 1990-02-12
CS271474B2 true CS271474B2 (en) 1990-10-12

Family

ID=10961386

Family Applications (1)

Application Number Title Priority Date Filing Date
CS875275A CS271474B2 (en) 1986-07-10 1987-07-10 Method of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine preparation

Country Status (15)

Country Link
US (1) US4960888A (fi)
EP (1) EP0252515A1 (fi)
JP (1) JPS6323872A (fi)
KR (1) KR920002127B1 (fi)
CN (1) CN1020724C (fi)
CA (1) CA1297479C (fi)
CS (1) CS271474B2 (fi)
DD (1) DD263989A5 (fi)
DK (1) DK361387A (fi)
FI (1) FI873050A (fi)
HU (1) HU196067B (fi)
IL (1) IL83155A (fi)
PL (1) PL151850B1 (fi)
SU (1) SU1498390A3 (fi)
ZA (1) ZA875050B (fi)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196061B (en) * 1986-07-10 1988-09-28 Richter Gedeon Vegyeszet Process for production of pirimidine-derivatives
US4959475A (en) 1989-01-04 1990-09-25 Lonza Ltd. Process for the production of 2,4-diamino-6-piperidinyl-pyrimidine-3-N-oxide
CN107235919B (zh) * 2017-06-22 2020-05-12 安徽拜善晟制药有限公司 一种米诺地尔的合成工艺
CN107987027A (zh) * 2018-01-18 2018-05-04 天津药物研究院药业有限责任公司 一种米诺地尔晶体、制备方法及含有此晶体的药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382248A (en) * 1965-11-01 1968-05-07 Upjohn Co 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines
US3644364A (en) * 1970-03-31 1972-02-22 Upjohn Co Compounds and process
US3998827A (en) * 1971-04-07 1976-12-21 The Upjohn Company 6-amino-4-(substituted piperidino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines
HU177601B (en) * 1978-10-27 1981-11-28 Egyt Gyogyszervegyeszeti Gyar New process for preparing 6-piperidino-2,4-diamino-pyrimidine-3-oxide
CA1179344A (en) * 1981-07-15 1984-12-11 Jean-Claude Muller Process for the preparation of 6-¬3,6-dihydro-1(2h)- pyridyl| pyrimidine-3-oxides

Also Published As

Publication number Publication date
HUT44531A (en) 1988-03-28
HU196067B (en) 1988-09-28
KR920002127B1 (ko) 1992-03-12
DK361387D0 (da) 1987-07-10
ZA875050B (en) 1988-03-30
US4960888A (en) 1990-10-02
CN87104694A (zh) 1988-02-03
SU1498390A3 (ru) 1989-07-30
JPS6323872A (ja) 1988-02-01
FI873050A (fi) 1988-01-11
DK361387A (da) 1988-01-11
IL83155A (en) 1991-09-16
CN1020724C (zh) 1993-05-19
KR880001632A (ko) 1988-04-25
IL83155A0 (en) 1987-12-31
PL266755A1 (en) 1988-06-23
DD263989A5 (de) 1989-01-18
CS527587A2 (en) 1990-02-12
EP0252515A1 (de) 1988-01-13
FI873050A0 (fi) 1987-07-10
CA1297479C (en) 1992-03-17
PL151850B1 (en) 1990-10-31

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