CS270577B2 - Method of quinoline carboxylic acids production - Google Patents

Method of quinoline carboxylic acids production Download PDF

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Publication number
CS270577B2
CS270577B2 CS878688A CS868887A CS270577B2 CS 270577 B2 CS270577 B2 CS 270577B2 CS 878688 A CS878688 A CS 878688A CS 868887 A CS868887 A CS 868887A CS 270577 B2 CS270577 B2 CS 270577B2
Authority
CS
Czechoslovakia
Prior art keywords
group
oxo
cyclopropyl
dihydro
fluoro
Prior art date
Application number
CS878688A
Other languages
Czech (cs)
English (en)
Other versions
CS868887A2 (en
Inventor
Michael Dr Preiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CS868887A2 publication Critical patent/CS868887A2/cs
Publication of CS270577B2 publication Critical patent/CS270577B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
CS878688A 1986-12-03 1987-11-30 Method of quinoline carboxylic acids production CS270577B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863641312 DE3641312A1 (de) 1986-12-03 1986-12-03 Verfahren zur herstellung von chinolincarbonsaeuren

Publications (2)

Publication Number Publication Date
CS868887A2 CS868887A2 (en) 1989-11-14
CS270577B2 true CS270577B2 (en) 1990-07-12

Family

ID=6315377

Family Applications (1)

Application Number Title Priority Date Filing Date
CS878688A CS270577B2 (en) 1986-12-03 1987-11-30 Method of quinoline carboxylic acids production

Country Status (25)

Country Link
EP (1) EP0274033B1 (fi)
JP (1) JPS63145268A (fi)
KR (1) KR970005191B1 (fi)
CN (1) CN87107230A (fi)
AT (1) ATE73446T1 (fi)
AU (1) AU593961B2 (fi)
CS (1) CS270577B2 (fi)
DD (1) DD270904A5 (fi)
DE (2) DE3641312A1 (fi)
DK (1) DK174929B1 (fi)
ES (1) ES2038156T3 (fi)
FI (1) FI875289A (fi)
GR (1) GR3004301T3 (fi)
HU (1) HU199823B (fi)
IE (1) IE64261B1 (fi)
IL (1) IL84627A (fi)
NO (1) NO174199C (fi)
NZ (1) NZ222736A (fi)
PH (1) PH24489A (fi)
PL (1) PL158614B1 (fi)
PT (1) PT86252B (fi)
SU (1) SU1482526A3 (fi)
UA (1) UA8017A1 (fi)
YU (1) YU45049B (fi)
ZA (1) ZA879040B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (fi) * 1985-09-18 1990-05-05 Pfizer
WO1990013542A1 (fr) * 1989-04-28 1990-11-15 Daiichi Pharmaceutical Co., Ltd. Medicament anti-hiv
WO1991004972A1 (en) * 1989-10-06 1991-04-18 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
ES2050613B1 (es) * 1992-10-16 1996-03-16 Iteve S A Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
WO1998042341A1 (fr) * 1997-03-25 1998-10-01 Sankyo Company, Limited Agent anti-vif
KR100454750B1 (ko) * 2002-06-20 2004-11-03 삼성에스디아이 주식회사 유기 전계 발광 소자용 청색 발광 화합물 및 이를 사용한유기 전계 발광 소자
CA2536429C (en) 2003-09-10 2012-02-14 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivative
EP2149571A4 (en) 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
CN101671302B (zh) * 2008-12-30 2011-03-30 广东海康兽药有限公司 禽畜用抗菌药恩诺沙星的生产工艺
CN101899044B (zh) * 2010-08-16 2012-07-18 常州市勇毅生物药业有限公司 吉米沙星主环化合物的合成方法
CN113912540A (zh) * 2021-12-15 2022-01-11 山东国邦药业有限公司 一种1-环丙基-6,7-二氟-1,4-二氢-4-氧代-3-喹啉甲酸的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
DE2656574A1 (de) * 1976-12-10 1978-06-15 Schering Ag Neue 1,6-naphthyridincarbonsaeurederivate und verfahren zu ihrer herstellung
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
CA1285279C (en) * 1984-02-17 1991-06-25 Joseph P. Sanchez 7-amine derivatives of 1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acids and 1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine- 3-carboxylic acidsas antibacterial agents
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法

Also Published As

Publication number Publication date
NO874788L (no) 1988-06-06
KR970005191B1 (ko) 1997-04-14
HU199823B (en) 1990-03-28
CN87107230A (zh) 1988-07-06
NZ222736A (en) 1990-08-28
IE64261B1 (en) 1995-07-26
HUT45521A (en) 1988-07-28
AU8217787A (en) 1988-06-09
NO174199B (no) 1993-12-20
PT86252B (pt) 1990-11-07
NO174199C (no) 1994-04-06
CS868887A2 (en) 1989-11-14
PL269185A1 (en) 1989-01-05
YU45049B (en) 1991-06-30
YU215687A (en) 1988-10-31
ATE73446T1 (de) 1992-03-15
DK633187A (da) 1988-06-04
PT86252A (en) 1988-01-01
PL158614B1 (pl) 1992-09-30
IL84627A0 (en) 1988-04-29
JPS63145268A (ja) 1988-06-17
ES2038156T3 (es) 1993-07-16
EP0274033B1 (de) 1992-03-11
FI875289A0 (fi) 1987-12-01
DE3777370D1 (de) 1992-04-16
EP0274033A1 (de) 1988-07-13
SU1482526A3 (ru) 1989-05-23
NO874788D0 (no) 1987-11-17
IL84627A (en) 1992-01-15
DD270904A5 (de) 1989-08-16
DE3641312A1 (de) 1988-06-09
ZA879040B (en) 1988-05-26
PH24489A (en) 1990-07-18
FI875289A (fi) 1988-06-04
GR3004301T3 (fi) 1993-03-31
UA8017A1 (uk) 1995-12-26
IE873279L (en) 1988-06-03
AU593961B2 (en) 1990-02-22
DK633187D0 (da) 1987-12-02
DK174929B1 (da) 2004-03-01
KR880007472A (ko) 1988-08-27

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20071130