CS270552B2 - Method of 3-oxa-6a-carbaprostaglandin-i2-derivative production - Google Patents

Method of 3-oxa-6a-carbaprostaglandin-i2-derivative production Download PDF

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Publication number
CS270552B2
CS270552B2 CS841036A CS103684A CS270552B2 CS 270552 B2 CS270552 B2 CS 270552B2 CS 841036 A CS841036 A CS 841036A CS 103684 A CS103684 A CS 103684A CS 270552 B2 CS270552 B2 CS 270552B2
Authority
CS
Czechoslovakia
Prior art keywords
tetrahydropyran
ether
yloxy
vacuo
solution
Prior art date
Application number
CS841036A
Other languages
Czech (cs)
English (en)
Other versions
CS103684A2 (en
Inventor
Werner Dr Skuballa
Berndt Dr Raduchel
Helmut Prof Vorbruggen
Claus-Steffen Dr Sturzebecher
Martin Dr Haberey
Ekkerhard Dr Schillinger
Michael-Harold Dr Town
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS103684A2 publication Critical patent/CS103684A2/cs
Publication of CS270552B2 publication Critical patent/CS270552B2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Basic Packing Technique (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Lubricants (AREA)
  • Medicinal Preparation (AREA)
CS841036A 1983-02-18 1984-02-14 Method of 3-oxa-6a-carbaprostaglandin-i2-derivative production CS270552B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833306123 DE3306123A1 (de) 1983-02-18 1983-02-18 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
CS103684A2 CS103684A2 (en) 1989-11-14
CS270552B2 true CS270552B2 (en) 1990-07-12

Family

ID=6191513

Family Applications (1)

Application Number Title Priority Date Filing Date
CS841036A CS270552B2 (en) 1983-02-18 1984-02-14 Method of 3-oxa-6a-carbaprostaglandin-i2-derivative production

Country Status (22)

Country Link
US (1) US5013758A (ja)
EP (1) EP0119949B1 (ja)
JP (1) JPH0611726B2 (ja)
AT (1) ATE38831T1 (ja)
AU (1) AU580728B2 (ja)
CA (1) CA1251200A (ja)
CS (1) CS270552B2 (ja)
DD (1) DD216448A5 (ja)
DE (2) DE3306123A1 (ja)
DK (1) DK155828C (ja)
ES (1) ES529636A0 (ja)
FI (1) FI78065C (ja)
GR (1) GR81961B (ja)
HU (1) HU191994B (ja)
IE (1) IE56703B1 (ja)
IL (1) IL70905A (ja)
NO (1) NO157060C (ja)
NZ (1) NZ207061A (ja)
PH (1) PH21468A (ja)
SU (1) SU1384196A3 (ja)
YU (1) YU45173B (ja)
ZA (1) ZA841198B (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3610556A1 (de) * 1986-03-26 1987-10-01 Schering Ag 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung
US5169960A (en) * 1987-08-11 1992-12-08 Schering Aktiengesellschaft Process for the production of E/Z mixtures of 2-(bicyclo[3.3.0]octan-3-ylidene)-acetic acid derivatives with predominant E or Z portion
DE3727065A1 (de) * 1987-08-11 1989-02-23 Schering Ag Verfahren zur herstellung von e/z-gemischen von 2-(bicyclo-(3.3.0)-octan-3-yliden) -essigsaeurederivaten mit ueberwiegendem e- oder z-anteil
US5371284A (en) * 1987-09-03 1994-12-06 Schering Corporation Phenyl acetylenic acetals
DE3835162A1 (de) * 1988-10-13 1990-04-19 Schering Ag (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
DE3909329A1 (de) * 1989-03-17 1990-09-20 Schering Ag 20-alkyl-13,14,18,18,19,19-hexadehydro-3- oxa-isocarbacyclin-derivate und ihre pharmazeutische verwendung
DE3933523A1 (de) * 1989-10-05 1991-04-11 Schering Ag Antimetastatisch wirkende mittel
GB9011588D0 (en) * 1990-05-24 1990-07-11 Wellcome Found Prostaglandin analogues for use in medicine
DE4028864A1 (de) * 1990-09-07 1992-03-12 Schering Ag Verfahren zur herstellung von e/z-mischungen von 2-(6-alkyl-bicyclo-(3.3.0)-octan-3-yliden) -essigsaeure-derivaten mit ueberwiegendem anteil des e-isomeren
CA2237620A1 (en) * 1996-09-17 1998-03-26 Toray Industries, Inc. Platelet function increment agent and therapeutic method for thrombocytopathy
CA2574958A1 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
WO2008058766A1 (en) 2006-11-16 2008-05-22 Bayer Schering Pharma Aktiengesellschaft Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection
JP2013508282A (ja) 2009-10-14 2013-03-07 ジェンムス ファーマ インコーポレイティド ウイルス感染のための併用療法処置
TWI513462B (zh) 2009-11-13 2015-12-21 Toray Industries 糖尿病之治療或預防藥
CA2920856A1 (en) 2013-08-09 2015-02-12 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス, インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
IE56703B1 (en) 1991-11-06
CA1251200A (en) 1989-03-14
DD216448A5 (de) 1984-12-12
FI840635A0 (fi) 1984-02-16
DE3475302D1 (en) 1988-12-29
YU45173B (en) 1992-05-28
US5013758A (en) 1991-05-07
CS103684A2 (en) 1989-11-14
ZA841198B (en) 1984-09-26
DK55584A (da) 1984-08-19
DE3306123A1 (de) 1984-09-06
ES8500209A1 (es) 1984-11-01
JPH0611726B2 (ja) 1994-02-16
DK155828B (da) 1989-05-22
FI78065C (fi) 1989-06-12
FI78065B (fi) 1989-02-28
SU1384196A3 (ru) 1988-03-23
EP0119949A1 (de) 1984-09-26
EP0119949B1 (de) 1988-11-23
ES529636A0 (es) 1984-11-01
IE840236L (en) 1984-08-18
IL70905A (en) 1987-02-27
GR81961B (ja) 1984-12-12
AU2401584A (en) 1984-08-23
DK155828C (da) 1989-10-09
FI840635A (fi) 1984-08-19
NO840595L (no) 1984-08-20
NO157060C (no) 1988-01-13
YU24484A (en) 1986-06-30
JPS59157050A (ja) 1984-09-06
IL70905A0 (en) 1984-05-31
NO157060B (no) 1987-10-05
AU580728B2 (en) 1989-02-02
NZ207061A (en) 1987-06-30
HU191994B (en) 1987-04-28
PH21468A (en) 1987-10-28
DK55584D0 (da) 1984-02-08
ATE38831T1 (de) 1988-12-15

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