CS259862B2 - Method of macrolide derivatives production - Google Patents

Method of macrolide derivatives production Download PDF

Info

Publication number
CS259862B2
CS259862B2 CS836653A CS665383A CS259862B2 CS 259862 B2 CS259862 B2 CS 259862B2 CS 836653 A CS836653 A CS 836653A CS 665383 A CS665383 A CS 665383A CS 259862 B2 CS259862 B2 CS 259862B2
Authority
CS
Czechoslovakia
Prior art keywords
desmycosine
mmol
formula
derivatives
mixture
Prior art date
Application number
CS836653A
Other languages
Czech (cs)
English (en)
Other versions
CS665383A2 (en
Inventor
Manuel Debono
Herbert A Kirst
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS665383A2 publication Critical patent/CS665383A2/cs
Publication of CS259862B2 publication Critical patent/CS259862B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Fodder In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CS836653A 1982-09-13 1983-09-13 Method of macrolide derivatives production CS259862B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41724782A 1982-09-13 1982-09-13

Publications (2)

Publication Number Publication Date
CS665383A2 CS665383A2 (en) 1988-04-15
CS259862B2 true CS259862B2 (en) 1988-11-15

Family

ID=23653182

Family Applications (1)

Application Number Title Priority Date Filing Date
CS836653A CS259862B2 (en) 1982-09-13 1983-09-13 Method of macrolide derivatives production

Country Status (34)

Country Link
EP (1) EP0103465B1 (xx)
JP (1) JPS5973598A (xx)
KR (1) KR850000961B1 (xx)
AR (1) AR241595A1 (xx)
AT (1) AT381707B (xx)
AU (1) AU561147B2 (xx)
BG (1) BG42675A3 (xx)
CA (1) CA1243310A (xx)
CS (1) CS259862B2 (xx)
CY (1) CY1417A (xx)
DD (1) DD210284A5 (xx)
DE (1) DE3366097D1 (xx)
DK (1) DK153555C (xx)
EG (1) EG16287A (xx)
ES (2) ES8604596A1 (xx)
FI (1) FI73222C (xx)
GB (1) GB2127017B (xx)
GR (1) GR79067B (xx)
HK (1) HK21888A (xx)
HU (1) HU194271B (xx)
IE (1) IE55916B1 (xx)
IL (1) IL69666A (xx)
LU (1) LU90240I2 (xx)
MY (1) MY8700756A (xx)
NL (1) NL950001I2 (xx)
NZ (1) NZ205501A (xx)
PH (1) PH23242A (xx)
PL (2) PL142304B1 (xx)
PT (1) PT77335B (xx)
RO (1) RO89235A (xx)
SG (1) SG99287G (xx)
SU (1) SU1375135A3 (xx)
UA (1) UA6045A1 (xx)
ZA (1) ZA836741B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59181294A (ja) * 1983-03-30 1984-10-15 Satoshi Omura 抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法
US4921947A (en) * 1986-03-31 1990-05-01 Eli Lilly And Company Process for preparing macrolide derivatives
EP0262903A3 (en) * 1986-09-29 1988-11-02 Eli Lilly And Company New acyl derivatives of 20-modified tylosin and desmycosin compounds
US4820694A (en) * 1986-09-29 1989-04-11 Eli Lilly And Company Modifications of 3-O-demethylmycinose in macrocin and lactenocin
US5354708A (en) * 1992-06-04 1994-10-11 Taskar Nikhil R Method of nitrogen doping of II-VI semiconductor compounds during epitaxial growth using an amine
TW226373B (xx) * 1992-07-15 1994-07-11 Pfizer
ES2076107B1 (es) * 1993-09-20 1996-04-01 Pfizer Derivados de antibioticos macrolidos de anillos de 16 miembros.
WO1996009312A1 (en) * 1994-09-22 1996-03-28 Pfizer Inc. Antibiotic macrolides
EP0778283A3 (en) * 1995-12-05 1998-01-28 Pfizer Inc. Antibiotic macrolides
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
CO5080775A1 (es) * 1998-03-02 2001-09-25 Lilly Co Eli Tratamiento de enfermedad viral en cerdos
EP2019112A1 (en) 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms
AU2007278195B2 (en) 2006-07-28 2012-09-13 Intervet International B.V. Macrolide synthesis process
JP5496908B2 (ja) * 2007-12-07 2014-05-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼラレノンマクロライドアナログを作製するための中間体および方法
UA117751C2 (uk) * 2013-05-23 2018-09-25 Байєр Енімал Хелс Гмбх Похідні тилозину і спосіб їх одержання
CN103880903B (zh) * 2014-03-21 2016-06-15 烟台万润药业有限公司 一种泰乐菌素类大环内酯及其衍生物的制备方法
CN117510561B (zh) * 2023-11-30 2024-04-02 中国农业科学院饲料研究所 一种泰乐菌素衍生物及其制备方法与应用
CN117304241B (zh) * 2023-11-30 2024-03-01 中国农业科学院饲料研究所 一种大环内酯类化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32839B1 (en) * 1967-12-04 1973-12-28 Lilly Co Eli Urea-antibiotic adducts and process for preparing the same
US4279896A (en) * 1980-06-23 1981-07-21 Schering Corporation Novel 20-imino macrolide antibacterial agents
JPS58146595A (ja) * 1982-02-25 1983-09-01 Satoshi Omura マクロライド系抗生物質

Also Published As

Publication number Publication date
EG16287A (en) 1987-04-30
DK153555B (da) 1988-07-25
LU90240I2 (fr) 1998-07-06
GB8324044D0 (en) 1983-10-12
GR79067B (xx) 1984-10-02
ES8604596A1 (es) 1986-02-01
MY8700756A (en) 1987-12-31
HK21888A (en) 1988-03-31
ES548472A0 (es) 1986-06-01
FI833229A (fi) 1984-03-14
DD210284A5 (de) 1984-06-06
CS665383A2 (en) 1988-04-15
DK153555C (da) 1988-12-05
IL69666A (en) 1987-10-20
PT77335B (en) 1986-05-19
UA6045A1 (uk) 1994-12-29
IE55916B1 (en) 1991-02-27
NL950001I1 (nl) 1995-02-16
JPS5973598A (ja) 1984-04-25
JPH021840B2 (xx) 1990-01-12
ES525544A0 (es) 1986-02-01
DE3366097D1 (en) 1986-10-16
KR840005734A (ko) 1984-11-15
EP0103465B1 (en) 1986-09-10
BG42675A3 (en) 1988-01-15
DK413783A (da) 1984-03-14
PL250619A1 (en) 1985-07-30
EP0103465A1 (en) 1984-03-21
AT381707B (de) 1986-11-25
PH23242A (en) 1989-06-06
AU561147B2 (en) 1987-04-30
PL142304B1 (en) 1987-10-31
IE832131L (en) 1984-03-13
AR241595A1 (es) 1992-09-30
HUT35272A (en) 1985-06-28
NZ205501A (en) 1985-09-13
ZA836741B (en) 1984-04-25
CY1417A (en) 1988-04-22
ES8607336A1 (es) 1986-06-01
GB2127017A (en) 1984-04-04
KR850000961B1 (ko) 1985-07-02
FI73222C (fi) 1987-09-10
FI73222B (fi) 1987-05-29
NL950001I2 (nl) 1997-05-01
DK413783D0 (da) 1983-09-12
GB2127017B (en) 1986-01-15
PL243718A1 (en) 1985-04-09
IL69666A0 (en) 1983-12-30
PT77335A (en) 1983-10-01
HU194271B (en) 1988-01-28
AU1871083A (en) 1984-03-22
PL142251B1 (en) 1987-10-31
SG99287G (en) 1988-09-23
ATA320683A (de) 1986-04-15
CA1243310A (en) 1988-10-18
FI833229A0 (fi) 1983-09-09
SU1375135A3 (ru) 1988-02-15
RO89235A (ro) 1986-03-15

Similar Documents

Publication Publication Date Title
US4820695A (en) C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
CS259862B2 (en) Method of macrolide derivatives production
EP0001841B1 (en) Tylosin derivatives
US4440759A (en) 20-Amino tylosin derivatives and pharmaceutical compositions containing same
EP0203621B1 (en) C-20-modified macrolide derivatives
GB2148304A (en) N-acyl glycopeptide derivatives
EP0201166B1 (en) Erythromycin derivatives
US4468511A (en) C-20- And C-23-Modified macrolide derivatives
US4629786A (en) C-20- and C-23 modified macrolide derivatives
EP0262904A2 (en) Modifications of mycinose and 3-0-demethylmycinose in tylosintype macrolides
US4820694A (en) Modifications of 3-O-demethylmycinose in macrocin and lactenocin
US4401660A (en) Ester derivatives of 5-O-mycaminosyl tylonolide and method of using same
US4452784A (en) C-23-Modified derivatives of DMT
US4396613A (en) 23-Ester derivatives of DMT and method of using same
US4686207A (en) Erythromycin A 11,12-carbonates and method of use
EP0262903A2 (en) New acyl derivatives of 20-modified tylosin and desmycosin compounds
US4604380A (en) C-23-substituted mycaminosyltylonolide compounds, pharmaceutical compositions and methods of use
US4436733A (en) 4"- And 3-ester derivatives of DMT and DMOT
US4482545A (en) Isoefrotomycin, process of preparation, pharmaceutical composition and method of using same
BG60758B2 (bg) С-20-дихидро-дезокси-(циклени амино)-производни на макролидни антибиотици
AT390733B (de) Verfahren zur behandlung oder unterdrueckung mikrobieller infektionen in einem warmbluetigen tier