CS258498B2 - Method of androsta-1,4-dien-3,17-diones production - Google Patents

Method of androsta-1,4-dien-3,17-diones production Download PDF

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Publication number
CS258498B2
CS258498B2 CS873216A CS321686A CS258498B2 CS 258498 B2 CS258498 B2 CS 258498B2 CS 873216 A CS873216 A CS 873216A CS 321686 A CS321686 A CS 321686A CS 258498 B2 CS258498 B2 CS 258498B2
Authority
CS
Czechoslovakia
Prior art keywords
dione
diene
formula
methylenandrosta
compounds
Prior art date
Application number
CS873216A
Other languages
Czech (cs)
English (en)
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Sale Enrico Di
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS258498(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of CS258498B2 publication Critical patent/CS258498B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS873216A 1985-07-09 1986-07-09 Method of androsta-1,4-dien-3,17-diones production CS258498B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (1)

Publication Number Publication Date
CS258498B2 true CS258498B2 (en) 1988-08-16

Family

ID=10582036

Family Applications (2)

Application Number Title Priority Date Filing Date
CS873216A CS258498B2 (en) 1985-07-09 1986-07-09 Method of androsta-1,4-dien-3,17-diones production
CS865214A CS257794B2 (en) 1985-07-09 1986-07-09 Method of substituted androsta-1,4-diene-3,17-dienes production

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS865214A CS257794B2 (en) 1985-07-09 1986-07-09 Method of substituted androsta-1,4-diene-3,17-dienes production

Country Status (38)

Country Link
US (2) US4808616A (fi)
JP (1) JPS6212797A (fi)
KR (1) KR950003614B1 (fi)
CN (1) CN86104664B (fi)
AT (1) AT395157B (fi)
AU (1) AU578840B2 (fi)
BE (1) BE905067A (fi)
BG (1) BG61370B2 (fi)
BR (1) BR1100240A (fi)
CA (1) CA1277656C (fi)
CH (1) CH668599A5 (fi)
CS (2) CS258498B2 (fi)
CZ (1) CZ413591A3 (fi)
DE (1) DE10199030I1 (fi)
DK (1) DK163520C (fi)
ES (2) ES8801304A1 (fi)
FI (1) FI83424C (fi)
FR (1) FR2584725B1 (fi)
GB (2) GB8517360D0 (fi)
GR (1) GR861780B (fi)
HK (1) HK94190A (fi)
HU (1) HU194274B (fi)
IE (1) IE58949B1 (fi)
IL (1) IL79336A (fi)
IT (1) IT1196436B (fi)
MY (1) MY102294A (fi)
NL (2) NL193616C (fi)
NO (2) NO165547C (fi)
NZ (1) NZ216763A (fi)
PH (1) PH21785A (fi)
PT (1) PT82944B (fi)
SE (1) SE468988B (fi)
SG (1) SG80490G (fi)
SK (1) SK413591A3 (fi)
SU (2) SU1442077A3 (fi)
UA (1) UA6046A1 (fi)
YU (2) YU44585B (fi)
ZA (1) ZA865079B (fi)

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GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
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GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
US5519051A (en) * 1991-03-28 1996-05-21 Teikoku Hormone Mfg. Co., Ltd. Oxa- or azasteroid derivatives
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
US5539127A (en) * 1992-09-30 1996-07-23 Teikoku Hormone Mfg. Co., Ltd. 7-substituted oxa- or azasteroid compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
WO2002011705A2 (en) * 2000-08-09 2002-02-14 Pharmacia Italia Spa Composition for combined use of aromatase inhibitors
BR0113625A (pt) * 2000-09-08 2003-07-22 Pharmacia Italia Spa Exemestano como agente de quimioprevenção
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
ES2269682T3 (es) * 2001-01-26 2007-04-01 Pfizer Italia S.R.L. Exemestano para tratar transtornos que dependen de hormonas.
CA2994779C (en) 2001-02-19 2020-08-25 Novartis Ag Use of 40-o-(2-hydroxyethyl)-rapamycin for inhibiting growth of a solid tumour of the brain other than lymphatic cancer
RU2318517C2 (ru) 2001-05-16 2008-03-10 Новартис Аг Комбинация, включающая n-{5-[4-(4-метилпиперазинометил)бензоиламидо]-2-метилфенил}-4-(3-пиридил)-2-пиримидинамин и химиотерапевтический агент
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
MXPA04011384A (es) 2002-05-16 2005-02-14 Novartis Ag Uso de agentes de union del receptor edg en cancer.
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
WO2005070951A1 (en) 2004-01-16 2005-08-04 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
WO2007041564A2 (en) 2005-09-30 2007-04-12 Endece, Llc (s)-6-methyloxaalkyl exemestane compounds and related methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
WO2007128820A1 (en) 2006-05-09 2007-11-15 Novartis Ag Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
MX2010004195A (es) 2007-10-16 2010-06-02 Repros Therapeutics Inc Trans-clomifeno para el sindrome metabolico.
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
US8288571B2 (en) * 2008-01-21 2012-10-16 Cadila Healthcare Limited Process for preparing aromatiase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
WO2010127297A1 (en) 2009-05-01 2010-11-04 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
EP2556082B1 (en) 2010-04-08 2017-02-22 Emory University Substituted androst-4-ene diones
WO2011128434A2 (en) 2010-04-16 2011-10-20 Novartis Ag Treatment of endocrine resistant breast cancer
WO2012037261A2 (en) 2010-09-14 2012-03-22 Endece, Llc 6-substituted demethyl-estradiol derivatives as er-beta agonists
WO2013130832A1 (en) 2012-02-29 2013-09-06 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
RU2016135413A (ru) 2014-02-11 2018-03-14 Новартис Аг Фармацевтические комбинации, включающие ингибитор pi3k, для лечения рака
EP3373967B9 (en) 2015-11-10 2023-10-04 Paracrine Therapeutics AB Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

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GB929985A (fi) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
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DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
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Also Published As

Publication number Publication date
SE8603046L (sv) 1987-01-10
BR1100240A (pt) 1999-12-28
ES8802429A1 (es) 1988-06-01
YU103687A (en) 1988-08-31
KR870001140A (ko) 1987-03-11
ES8801304A1 (es) 1987-12-16
SG80490G (en) 1990-11-23
NO862753L (no) 1987-01-12
DK163520B (da) 1992-03-09
GB8517360D0 (en) 1985-08-14
PT82944B (pt) 1989-01-30
CA1277656C (en) 1990-12-11
UA6046A1 (uk) 1994-12-29
JPH0443919B2 (fi) 1992-07-20
CH668599A5 (de) 1989-01-13
ATA181986A (de) 1992-02-15
SK413591A3 (en) 1995-07-11
MY102294A (en) 1992-05-15
PH21785A (en) 1988-02-24
FR2584725A1 (fr) 1987-01-16
HK94190A (en) 1990-11-23
CN86104664A (zh) 1987-02-18
CS257794B2 (en) 1988-06-15
PT82944A (en) 1986-08-01
DE10199030I1 (de) 2001-10-04
US4808616A (en) 1989-02-28
SE468988B (sv) 1993-04-26
YU120186A (en) 1988-02-29
BG61370B2 (bg) 1997-06-30
FR2584725B1 (fr) 1988-05-13
NL193616B (nl) 1999-12-01
IE58949B1 (en) 1993-12-01
NL300017I1 (nl) 2000-11-01
NL300017I2 (nl) 2001-01-02
AU578840B2 (en) 1988-11-03
IT1196436B (it) 1988-11-16
IL79336A0 (en) 1986-10-31
KR950003614B1 (ko) 1995-04-17
GB2177700B (en) 1988-12-07
DK324386A (da) 1987-01-10
CZ413591A3 (en) 1994-03-16
NO862753D0 (no) 1986-07-08
JPS6212797A (ja) 1987-01-21
ES557466A0 (es) 1988-06-01
ES556550A0 (es) 1987-12-16
GB2177700A (en) 1987-01-28
NO165547B (no) 1990-11-19
DK163520C (da) 1992-07-27
CS521486A2 (en) 1987-09-17
HUT42780A (en) 1987-08-28
GB8616585D0 (en) 1986-08-13
GR861780B (en) 1986-11-11
FI83424C (fi) 1991-07-10
DK324386D0 (da) 1986-07-08
BE905067A (fr) 1987-01-08
FI862871A0 (fi) 1986-07-07
IL79336A (en) 1991-06-10
NO165547C (no) 1991-02-27
US4904650A (en) 1990-02-27
YU44585B (en) 1990-10-31
IT8621004A0 (it) 1986-07-02
YU44628B (en) 1990-10-31
ZA865079B (en) 1987-03-25
AU5979986A (en) 1987-01-15
NZ216763A (en) 1988-05-30
SE8603046D0 (sv) 1986-07-08
NO2000009I1 (no) 2000-10-05
SU1501923A3 (ru) 1989-08-15
FI862871A (fi) 1987-01-10
IE861821L (en) 1987-01-09
HU194274B (en) 1988-01-28
FI83424B (fi) 1991-03-28
NL8601785A (nl) 1987-02-02
NL193616C (nl) 2000-04-04
CN86104664B (zh) 1988-06-29
AT395157B (de) 1992-10-12
SU1442077A3 (ru) 1988-11-30

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20010709