CS254319B2 - Method of imidazole derivatives production - Google Patents

Method of imidazole derivatives production Download PDF

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Publication number
CS254319B2
CS254319B2 CS834724A CS472483A CS254319B2 CS 254319 B2 CS254319 B2 CS 254319B2 CS 834724 A CS834724 A CS 834724A CS 472483 A CS472483 A CS 472483A CS 254319 B2 CS254319 B2 CS 254319B2
Authority
CS
Czechoslovakia
Prior art keywords
methoxy
group
formula
eine
calculated
Prior art date
Application number
CS834724A
Other languages
Czech (cs)
English (en)
Inventor
Norbert Hauel
Volkhard Austel
Joachim Heider
Manfred Reiffen
Willi Diederen
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of CS254319B2 publication Critical patent/CS254319B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS834724A 1982-07-01 1983-06-27 Method of imidazole derivatives production CS254319B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823224512 DE3224512A1 (de) 1982-07-01 1982-07-01 Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
CS254319B2 true CS254319B2 (en) 1988-01-15

Family

ID=6167285

Family Applications (1)

Application Number Title Priority Date Filing Date
CS834724A CS254319B2 (en) 1982-07-01 1983-06-27 Method of imidazole derivatives production

Country Status (23)

Country Link
US (2) US4582837A (fr)
EP (1) EP0098448A3 (fr)
JP (1) JPS5927875A (fr)
KR (1) KR840005432A (fr)
AU (1) AU1642883A (fr)
CS (1) CS254319B2 (fr)
DD (1) DD210271A5 (fr)
DE (1) DE3224512A1 (fr)
DK (1) DK301383A (fr)
ES (3) ES523709A0 (fr)
FI (1) FI832022L (fr)
GB (1) GB2122995B (fr)
GR (1) GR78598B (fr)
HU (1) HU192152B (fr)
IL (1) IL69111A0 (fr)
NO (1) NO832356L (fr)
NZ (1) NZ204766A (fr)
PH (1) PH20810A (fr)
PL (2) PL142880B1 (fr)
PT (1) PT76968B (fr)
SU (2) SU1316559A3 (fr)
YU (1) YU143283A (fr)
ZA (1) ZA834777B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines
GR851085B (fr) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
EP0178413A1 (fr) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
NZ217755A (en) * 1985-10-09 1989-08-29 Chemie Linz Ag 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and pharmaceutical compositions
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5466704A (en) * 1991-02-26 1995-11-14 E. R. Squibb & Sons, Inc. N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
FR2677020B1 (fr) * 1991-05-31 1993-08-27 Cird Galderma Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
BR9916363A (pt) 1998-12-18 2001-12-11 Axys Pharm Inc Composto, composição farmacêutica e método paratratar ou prevenir um distúrbio tromboembólico
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
DE10015866A1 (de) * 2000-03-30 2001-10-11 Bayer Ag Aryl- und Heteroarylsulfonate
US6943174B2 (en) 2000-06-14 2005-09-13 Warner-Lambert Company 6,5-Fused bicyclic heterocycles
RU2003127367A (ru) * 2001-03-12 2005-03-20 Аванир Фармасьютиклз (Us) Бензимидазоловые соединения для модулирования ige и ингибирования клеточной пролиферации
JP4416111B2 (ja) * 2002-02-14 2010-02-17 塩野義製薬株式会社 ２，３−ジアミノピリジン誘導体の製造方法
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
AU2004263190A1 (en) * 2003-08-08 2005-02-17 Avanir Pharmaceuticals Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
JPWO2007004688A1 (ja) * 2005-07-01 2009-01-29 日本ケミファ株式会社 キサンチンオキシダーゼ阻害剤
AU2006279537A1 (en) * 2005-08-15 2007-02-22 Irm Llc Compounds and compositions as TPO mimetics
CL2007003443A1 (es) * 2006-11-30 2008-07-11 Wyeth6 3 Compuestos derivados de benzoxazoles sustituidos; procedimiento de preparacion, utiles como agentes estrogenicos.
US7816540B2 (en) * 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
US9233961B2 (en) 2013-03-15 2016-01-12 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
BR112016014004B1 (pt) 2013-12-19 2022-11-01 Novartis Ag Compostos para tratamento de doenças parasíticas, seus usos, e composições farmacêuticas
AR099677A1 (es) * 2014-03-07 2016-08-10 Sumitomo Chemical Co Compuesto heterocíclico fusionado y su uso para el control de plagas
JP2019503342A (ja) * 2015-11-16 2019-02-07 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305339C3 (de) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
EP0072926B1 (fr) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Arylimidazopyridines
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Also Published As

Publication number Publication date
PT76968A (de) 1983-07-01
DE3224512A1 (de) 1984-01-05
ES8500242A1 (es) 1984-10-01
PL242770A1 (en) 1986-10-21
PL144589B1 (en) 1988-06-30
GB2122995B (en) 1986-02-12
YU143283A (en) 1986-06-30
DD210271A5 (de) 1984-06-06
KR840005432A (ko) 1984-11-12
EP0098448A3 (fr) 1985-04-03
PH20810A (en) 1987-04-24
EP0098448A2 (fr) 1984-01-18
PT76968B (de) 1986-04-09
ES8500056A1 (es) 1984-10-01
ES523709A0 (es) 1984-10-01
NO832356L (no) 1984-01-02
US4696931A (en) 1987-09-29
DK301383A (da) 1984-01-02
FI832022A0 (fi) 1983-06-06
JPS5927875A (ja) 1984-02-14
ES529175A0 (es) 1984-10-01
US4582837A (en) 1986-04-15
SU1316559A3 (ru) 1987-06-07
GR78598B (fr) 1984-09-27
SU1179924A3 (ru) 1985-09-15
NZ204766A (en) 1986-09-10
HU192152B (en) 1987-05-28
IL69111A0 (en) 1983-10-31
ES8500241A1 (es) 1984-10-01
GB8317732D0 (en) 1983-08-03
PL142880B1 (en) 1987-12-31
ZA834777B (en) 1985-03-27
ES529174A0 (es) 1984-10-01
GB2122995A (en) 1984-01-25
DK301383D0 (da) 1983-06-30
AU1642883A (en) 1984-01-05
FI832022L (fi) 1984-01-02

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