CS235072B2 - Method of l-tyrosyl-d-alanyl-glycyl-l-phenylalanylamide's new derivatives production - Google Patents
Method of l-tyrosyl-d-alanyl-glycyl-l-phenylalanylamide's new derivatives production Download PDFInfo
- Publication number
- CS235072B2 CS235072B2 CS786285A CS628578A CS235072B2 CS 235072 B2 CS235072 B2 CS 235072B2 CS 786285 A CS786285 A CS 786285A CS 628578 A CS628578 A CS 628578A CS 235072 B2 CS235072 B2 CS 235072B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- acid
- acetic acid
- tyrosyl
- glycyl
- alanyl
- Prior art date
Links
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- 150000003839 salts Chemical class 0.000 claims abstract description 17
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
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- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract description 2
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 53
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- 239000000243 solution Substances 0.000 description 31
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- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
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- 239000000376 reactant Substances 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/838,516 US4264491A (en) | 1977-10-03 | 1977-10-03 | Analgesic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS235072B2 true CS235072B2 (en) | 1985-04-16 |
Family
ID=25277291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS786285A CS235072B2 (en) | 1977-10-03 | 1978-09-28 | Method of l-tyrosyl-d-alanyl-glycyl-l-phenylalanylamide's new derivatives production |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US4264491A (ro) |
| EP (1) | EP0001684B1 (ro) |
| JP (1) | JPS5459247A (ro) |
| AR (1) | AR224238A1 (ro) |
| AT (1) | AT367028B (ro) |
| AU (1) | AU520315B2 (ro) |
| BE (1) | BE870819A (ro) |
| BG (1) | BG31224A3 (ro) |
| CA (1) | CA1156219A (ro) |
| CH (1) | CH635571A5 (ro) |
| CS (1) | CS235072B2 (ro) |
| DD (1) | DD139710A5 (ro) |
| DE (1) | DE2861019D1 (ro) |
| DK (1) | DK149231C (ro) |
| EG (1) | EG13636A (ro) |
| ES (1) | ES473925A1 (ro) |
| FI (1) | FI66842C (ro) |
| FR (1) | FR2404629B1 (ro) |
| GB (1) | GB2005688B (ro) |
| GR (1) | GR71651B (ro) |
| HU (1) | HU182866B (ro) |
| IE (1) | IE47378B1 (ro) |
| IL (1) | IL55650A (ro) |
| IT (1) | IT1100839B (ro) |
| LU (1) | LU80316A1 (ro) |
| NZ (1) | NZ188521A (ro) |
| PH (1) | PH14660A (ro) |
| PL (1) | PL114271B1 (ro) |
| PT (1) | PT68598A (ro) |
| RO (1) | RO76176A (ro) |
| SU (1) | SU908246A3 (ro) |
| YU (1) | YU231578A (ro) |
| ZA (1) | ZA785564B (ro) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK28377A (da) | 1976-02-02 | 1977-08-03 | Sandoz Ag | Fremgangsmade til fremstilling af polypeptidderivater |
| US4331593A (en) * | 1977-10-03 | 1982-05-25 | Smithwick Jr Edward L | Analgesic compounds |
| US4333873A (en) | 1979-12-17 | 1982-06-08 | Eli Lilly And Company | Pharmacologically active peptides |
| US4283330A (en) * | 1979-12-17 | 1981-08-11 | Eli Lilly And Company | Pharmacologically active peptides |
| US4265808A (en) * | 1979-12-17 | 1981-05-05 | Eli Lilly And Company | Pharmacologically active peptides |
| JPS5692846A (en) * | 1979-12-27 | 1981-07-27 | Takeda Chem Ind Ltd | Tetrapeptide derivative and its preparation |
| FR2488253A1 (fr) * | 1980-08-08 | 1982-02-12 | Roques Bernard | Nouveaux peptides et leur application en therapeutique |
| JPS5738756A (en) * | 1980-08-18 | 1982-03-03 | Earth Chem Corp Ltd | Tripeptide alkylamide derivative |
| JPS5785349A (en) * | 1980-11-14 | 1982-05-28 | Earth Chem Corp Ltd | Tripeptide alkylamide derivative |
| US4322340A (en) * | 1980-10-20 | 1982-03-30 | Eli Lilly And Company | Pharmacologically active peptides |
| JPS5772950A (en) * | 1980-10-24 | 1982-05-07 | Takeda Chem Ind Ltd | Tetrapeptide derivative, its preparation and analgesic agent |
| EP0076557B1 (en) * | 1981-06-22 | 1985-11-13 | Imperial Chemical Industries Plc | Peptides and pseudopeptides in which the n terminus bears two substituents |
| US4448717A (en) * | 1982-11-12 | 1984-05-15 | Eli Lilly And Company | Pharmacologically active peptides |
| US4495178A (en) * | 1983-10-06 | 1985-01-22 | G. D. Searle & Co. | Enkephalin analogs |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1042487A (en) * | 1964-06-25 | 1966-09-14 | Ici Ltd | Polypeptide derivatives |
| DE2703109A1 (de) * | 1976-01-26 | 1977-08-04 | Wellcome Found | Biologisch wirksame amide |
| GB1532181A (en) * | 1976-02-02 | 1978-11-15 | Beckman Instruments Inc | Pentapetides and a method of preparing them |
| DK28377A (da) * | 1976-02-02 | 1977-08-03 | Sandoz Ag | Fremgangsmade til fremstilling af polypeptidderivater |
| US4028319A (en) * | 1976-05-07 | 1977-06-07 | G. D. Searle & Co. | 2 and 3-substituted enkephalins |
| FR2359817A1 (fr) * | 1976-07-27 | 1978-02-24 | Reckitt & Colmann Prod Ltd | Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant |
| DK326477A (da) * | 1976-07-27 | 1978-01-28 | Reckitt & Colmann Prod Ltd | Kemiske forbindelser og fremgangsmade til fremstilling af samme |
| US4259234A (en) * | 1976-09-27 | 1981-03-31 | Eli Lilly And Company | Analgesic compounds |
-
1977
- 1977-10-03 US US05/838,516 patent/US4264491A/en not_active Expired - Lifetime
-
1978
- 1978-09-26 CA CA000312073A patent/CA1156219A/en not_active Expired
- 1978-09-26 IE IE1926/78A patent/IE47378B1/en unknown
- 1978-09-27 IL IL55650A patent/IL55650A/xx unknown
- 1978-09-27 GB GB7838386A patent/GB2005688B/en not_active Expired
- 1978-09-27 AU AU40247/78A patent/AU520315B2/en not_active Expired
- 1978-09-27 PT PT68598A patent/PT68598A/pt unknown
- 1978-09-27 DE DE7878300420T patent/DE2861019D1/de not_active Expired
- 1978-09-27 NZ NZ188521A patent/NZ188521A/xx unknown
- 1978-09-27 EP EP78300420A patent/EP0001684B1/en not_active Expired
- 1978-09-28 JP JP11984778A patent/JPS5459247A/ja active Pending
- 1978-09-28 CS CS786285A patent/CS235072B2/cs unknown
- 1978-09-28 BE BE1009078A patent/BE870819A/xx not_active IP Right Cessation
- 1978-09-29 PH PH21652A patent/PH14660A/en unknown
- 1978-09-29 HU HU78EI814A patent/HU182866B/hu unknown
- 1978-09-29 FI FI782971A patent/FI66842C/fi not_active IP Right Cessation
- 1978-09-29 FR FR7827954A patent/FR2404629B1/fr not_active Expired
- 1978-10-02 DK DK434778A patent/DK149231C/da not_active IP Right Cessation
- 1978-10-02 AT AT0708778A patent/AT367028B/de not_active IP Right Cessation
- 1978-10-02 ZA ZA785564A patent/ZA785564B/xx unknown
- 1978-10-02 SU SU782669396A patent/SU908246A3/ru active
- 1978-10-02 YU YU02315/78A patent/YU231578A/xx unknown
- 1978-10-02 IT IT28359/78A patent/IT1100839B/it active
- 1978-10-02 BG BG040985A patent/BG31224A3/xx unknown
- 1978-10-02 CH CH1020578A patent/CH635571A5/fr not_active IP Right Cessation
- 1978-10-02 RO RO7895316A patent/RO76176A/ro unknown
- 1978-10-02 GR GR57355A patent/GR71651B/el unknown
- 1978-10-03 PL PL1978210045A patent/PL114271B1/pl unknown
- 1978-10-03 DD DD78208248A patent/DD139710A5/de unknown
- 1978-10-03 AR AR273938A patent/AR224238A1/es active
- 1978-10-03 EG EG585/78A patent/EG13636A/xx active
- 1978-10-03 ES ES473925A patent/ES473925A1/es not_active Expired
- 1978-10-03 LU LU80316A patent/LU80316A1/xx unknown
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