FR2359817A1 - Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant - Google Patents

Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant

Info

Publication number
FR2359817A1
FR2359817A1 FR7722766A FR7722766A FR2359817A1 FR 2359817 A1 FR2359817 A1 FR 2359817A1 FR 7722766 A FR7722766 A FR 7722766A FR 7722766 A FR7722766 A FR 7722766A FR 2359817 A1 FR2359817 A1 FR 2359817A1
Authority
FR
France
Prior art keywords
alkyl
phenyl
phe
beta
stimulants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7722766A
Other languages
English (en)
Other versions
FR2359817B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB31194/76A external-priority patent/GB1577115A/en
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of FR2359817A1 publication Critical patent/FR2359817A1/fr
Application granted granted Critical
Publication of FR2359817B1 publication Critical patent/FR2359817B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Abstract

Nouveaux peptides et leurs sels d'addition d'acides. On obtient ces peptides par un procédé dans lequel une matière première protégée, renfermant un résidu d'amino-acide ou de peptide, est condensée avec un composé protégé renfermant egalement un résidu d'amino-acide ou de peptide, les groupes protecteurs étant ensuite éliminés du produit résultant. Ces nouveaux peptides déploient une activité pharmacologique dans le test portant sur la préparation de canal déférent de la souris avec stimulation transmurale.
FR7722766A 1976-07-27 1977-07-25 Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant Granted FR2359817A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB31194/76A GB1577115A (en) 1976-07-27 1976-07-27 Container closure units
GB524777 1977-02-09

Publications (2)

Publication Number Publication Date
FR2359817A1 true FR2359817A1 (fr) 1978-02-24
FR2359817B1 FR2359817B1 (fr) 1981-01-02

Family

ID=26239753

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7722766A Granted FR2359817A1 (fr) 1976-07-27 1977-07-25 Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant

Country Status (1)

Country Link
FR (1) FR2359817A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000559A1 (fr) * 1977-07-22 1979-02-07 The Wellcome Foundation Limited Pentapeptide-N-alkoylamides et leurs sels, procédé de préparation de ces produits et leurs compositions pharmacologiques
FR2404629A1 (fr) * 1977-10-03 1979-04-27 Lilly Co Eli Nouveaux tetrapeptides et leur utilisation therapeutique
FR2404628A1 (fr) * 1977-09-29 1979-04-27 Reckitt & Colmann Prod Ltd Amide soufre de tetrapeptides, leur procede d'obtention et compositions therapeutiques les contenant
EP0002236A1 (fr) * 1977-11-24 1979-06-13 The Wellcome Foundation Limited Peptides, leurs sels, leurs sels d'addition acides, leurs formulations pharmacologiques et leur emploi comme antagonistes de morphine et comme anesthésiques
EP0005248A2 (fr) * 1978-05-02 1979-11-14 Takeda Chemical Industries, Ltd. Dérivés d'hydrazides de tétrapeptides et procédé pour leur préparation
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
EP0030847A2 (fr) * 1979-12-17 1981-06-24 Eli Lilly And Company Peptides à activité pharmacologique, leur préparation et compositions pharmaceutiques les contenant
EP0031567A2 (fr) * 1979-12-27 1981-07-08 Takeda Chemical Industries, Ltd. Dérivés de tétrapeptidesemicarbazide, leur production et leur utilisation
EP0081838A1 (fr) * 1981-12-14 1983-06-22 G.D. Searle & Co. Enképhalines substituées par des cyclohexyles et phényles
WO1995004072A1 (fr) * 1993-07-30 1995-02-09 Chiron Corporation Ligands du recepteur alpha-1 adrenergique peptoïdique
WO1997007129A1 (fr) * 1995-08-18 1997-02-27 Biochem Pharma Inc. Synthese en solution de tetrapeptides opioides analgesiques a action peripherique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2338925A1 (fr) * 1976-01-26 1977-08-19 Wellcome Found Nouveaux peptides et medicament contenant ces substances
FR2339590A1 (fr) * 1976-02-02 1977-08-26 Sandoz Sa Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments
FR2347336A1 (fr) * 1976-04-08 1977-11-04 Ici Ltd Derives peptidiques
FR2364890A1 (fr) * 1976-09-16 1978-04-14 Richter Gedeon Vegyeszet Nouveaux pentapeptides et procede pour leur preparation
FR2364889A1 (fr) * 1976-09-01 1978-04-14 Coy David Nouveaux derives encephaliniques a la methionine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2338925A1 (fr) * 1976-01-26 1977-08-19 Wellcome Found Nouveaux peptides et medicament contenant ces substances
FR2339590A1 (fr) * 1976-02-02 1977-08-26 Sandoz Sa Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments
FR2347336A1 (fr) * 1976-04-08 1977-11-04 Ici Ltd Derives peptidiques
FR2364889A1 (fr) * 1976-09-01 1978-04-14 Coy David Nouveaux derives encephaliniques a la methionine
FR2364890A1 (fr) * 1976-09-16 1978-04-14 Richter Gedeon Vegyeszet Nouveaux pentapeptides et procede pour leur preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1976 *
NV2030/77 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000559A1 (fr) * 1977-07-22 1979-02-07 The Wellcome Foundation Limited Pentapeptide-N-alkoylamides et leurs sels, procédé de préparation de ces produits et leurs compositions pharmacologiques
FR2404628A1 (fr) * 1977-09-29 1979-04-27 Reckitt & Colmann Prod Ltd Amide soufre de tetrapeptides, leur procede d'obtention et compositions therapeutiques les contenant
FR2404629A1 (fr) * 1977-10-03 1979-04-27 Lilly Co Eli Nouveaux tetrapeptides et leur utilisation therapeutique
EP0002236A1 (fr) * 1977-11-24 1979-06-13 The Wellcome Foundation Limited Peptides, leurs sels, leurs sels d'addition acides, leurs formulations pharmacologiques et leur emploi comme antagonistes de morphine et comme anesthésiques
EP0005658A1 (fr) * 1978-04-27 1979-11-28 Laboratoire le Brun S.A. Société dite: Nouveaux dérivés de peptides analogues des enképhalines, leur procédé de préparation et leur application thérapeutique
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
EP0005248A2 (fr) * 1978-05-02 1979-11-14 Takeda Chemical Industries, Ltd. Dérivés d'hydrazides de tétrapeptides et procédé pour leur préparation
EP0005248A3 (en) * 1978-05-02 1979-11-28 Takeda Yakuhin Kogyo Kabushiki Kaisha Tetrapeptidehydrazide derivatives and process for their preparation
EP0030847A2 (fr) * 1979-12-17 1981-06-24 Eli Lilly And Company Peptides à activité pharmacologique, leur préparation et compositions pharmaceutiques les contenant
EP0030847A3 (en) * 1979-12-17 1981-10-14 Eli Lilly And Company Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them
EP0031567A2 (fr) * 1979-12-27 1981-07-08 Takeda Chemical Industries, Ltd. Dérivés de tétrapeptidesemicarbazide, leur production et leur utilisation
EP0031567A3 (fr) * 1979-12-27 1981-11-04 Takeda Chemical Industries, Ltd. Dérivés de tétrapeptidesemicarbazide, leur production et leur utilisation
EP0081838A1 (fr) * 1981-12-14 1983-06-22 G.D. Searle & Co. Enképhalines substituées par des cyclohexyles et phényles
WO1995004072A1 (fr) * 1993-07-30 1995-02-09 Chiron Corporation Ligands du recepteur alpha-1 adrenergique peptoïdique
WO1997007129A1 (fr) * 1995-08-18 1997-02-27 Biochem Pharma Inc. Synthese en solution de tetrapeptides opioides analgesiques a action peripherique

Also Published As

Publication number Publication date
FR2359817B1 (fr) 1981-01-02

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Legal Events

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