GB1502573A - Somatostatin analogues - Google Patents

Somatostatin analogues

Info

Publication number
GB1502573A
GB1502573A GB32268/76A GB3226876A GB1502573A GB 1502573 A GB1502573 A GB 1502573A GB 32268/76 A GB32268/76 A GB 32268/76A GB 3226876 A GB3226876 A GB 3226876A GB 1502573 A GB1502573 A GB 1502573A
Authority
GB
United Kingdom
Prior art keywords
peptides
somatostatin
analogues
somatostatin analogues
isonicotinoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32268/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1502573A publication Critical patent/GB1502573A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The peptides of the formula I or I' are obtained from corresponding peptides whose lysine groups are protected with isonicotinoyl radicals by elimination of the protective groups with zinc dust in an aqueous solution of a lower alkanoic acid. The starting materials can be obtained by block synthesis from separately prepared peptide segments. The said peptides are analogues of somatostatin and have its biological activity but a longer duration of action. <IMAGE>
GB32268/76A 1975-08-08 1976-08-03 Somatostatin analogues Expired GB1502573A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60306775A 1975-08-08 1975-08-08
US68000576A 1976-04-23 1976-04-23

Publications (1)

Publication Number Publication Date
GB1502573A true GB1502573A (en) 1978-03-01

Family

ID=27084324

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32268/76A Expired GB1502573A (en) 1975-08-08 1976-08-03 Somatostatin analogues

Country Status (8)

Country Link
JP (1) JPS5219659A (en)
CH (1) CH626328A5 (en)
DE (1) DE2635558A1 (en)
DK (1) DK328876A (en)
FR (1) FR2320109A1 (en)
GB (1) GB1502573A (en)
NL (1) NL7607987A (en)
SE (1) SE419440B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7126001B2 (en) 1999-09-08 2006-10-24 Sloan-Kettering Institute For Cancer Research Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115554A (en) * 1977-08-29 1978-09-19 Merck & Co., Inc. Somatostatin analogs
LU78191A1 (en) * 1977-09-28 1979-05-25 Ciba Geigy Ag METHOD FOR PRODUCING NEW CYCLOPEPTIDES
US4139526A (en) * 1977-12-01 1979-02-13 Merck & Co., Inc. Somatostatin analogs
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
JPS5819669B2 (en) * 1978-10-28 1983-04-19 白井松新薬株式会社 Novel bioactive peptide compounds and their production methods
US4316890A (en) * 1979-03-16 1982-02-23 Ciba-Geigy Corporation Peptides and processes for the manufacture thereof
US4244947A (en) * 1979-08-13 1981-01-13 Ayerst Mckenna And Harrison Inc. Carba decapeptide derivatives of [TYR6 ]-somatostatin
NL8701143A (en) * 1986-05-27 1987-12-16 Sandoz Ag PHARMACEUTICAL PREPARATIONS.
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
ATE166359T1 (en) * 1991-08-09 1998-06-15 Winfried Kolbeck PEPTIDES WITH A LANTHIONINE BRIDGE
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6509712A (en) * 1964-07-27 1966-01-28
DE2460469A1 (en) * 1974-12-20 1976-07-01 Hoechst Ag Cyclic peptides inhibiting hormone release - prepd by cyclisation of linear undecapeptides contg a terminal omega- amino acid gp

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7126001B2 (en) 1999-09-08 2006-10-24 Sloan-Kettering Institute For Cancer Research Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
US7345174B2 (en) 1999-09-08 2008-03-18 Sloan-Kettering Institute For Cancer Research Cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

Also Published As

Publication number Publication date
SE419440B (en) 1981-08-03
CH626328A5 (en) 1981-11-13
DE2635558A1 (en) 1977-02-17
SE7608300L (en) 1977-02-09
JPS5219659A (en) 1977-02-15
DK328876A (en) 1977-02-09
FR2320109A1 (en) 1977-03-04
FR2320109B1 (en) 1979-05-25
NL7607987A (en) 1977-02-10

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee