ES9100003A1 - Un procedimiento para la preparacion de oxetanonas. - Google Patents

Un procedimiento para la preparacion de oxetanonas.

Info

Publication number
ES9100003A1
ES9100003A1 ES556896A ES556896A ES9100003A1 ES 9100003 A1 ES9100003 A1 ES 9100003A1 ES 556896 A ES556896 A ES 556896A ES 556896 A ES556896 A ES 556896A ES 9100003 A1 ES9100003 A1 ES 9100003A1
Authority
ES
Spain
Prior art keywords
alkyl
opt
ring
substd
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES556896A
Other languages
English (en)
Other versions
ES556896A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES556896A0 publication Critical patent/ES556896A0/es
Publication of ES9100003A1 publication Critical patent/ES9100003A1/es
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

CONSISTE EN PREPARAR UNA OXETANONA DE FORMULA (I), EN DONDE R ELEVADO A 1 Y R ELEVADO A 2 SON C1-17-ALQUILO OPCIONALMENTE INTERRUMPIDO POR HASTA 8 ENLACES DOBLES O TRIPLES, O POR UN ATOMO DE O O S QUE ESTA PRESENTE EN POSICION DISTINTA DE ALFA RESPECTO DE UN ATOMO DE C INSATURADO; O FENILO, BENCILO-C6H4-X-C6H5 SUSTITUIDO EN EL ANILLO POR 0 A 3 C1-6-ALEUILO-(O O S) 1 O 0, Y X ES OXIGENO, AZUFRE O (CH2)0-3. COMPRENDE DISOCIAR EL GRUPO PROTECTOR ESTERIO L EN UN ETER DE FORMULA (II), EN DONDE R ELEVADO A 1 Y R ELEVADO A 2 TIENEN EL MISMO SIGNIFICADO ANTERIOR, EN PRESENCIA DE UN PIRIDINO-4-TOLNENSULFONATO, LLEVANDOSE A CABO LA REACCION DE UN DISOLVENTE INERTE, TAL COMO METANOL O ETANOL, A UNA TEMPERATURA COMPRENDIDA ENTRE 40-65 *FORMULA*. POSEE PROPIEDADES FARMACOLOGICAS, EN PARTICULAR INHIBE LA LIPOSA DEL PANCREAS Y PUEDE EMPLEARSE EN EL CONTROL O PREVENCION DE LA OBESIDAD, HIPERLIPEMIA, ARTERIOSCLEROSIS, ETC. *FORMULA*
ES556896A 1984-12-21 1986-07-15 Un procedimiento para la preparacion de oxetanonas. Expired - Fee Related ES9100003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH610284 1984-12-21

Publications (2)

Publication Number Publication Date
ES556896A0 ES556896A0 (es) 1991-01-01
ES9100003A1 true ES9100003A1 (es) 1991-01-01

Family

ID=4304303

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556896A Expired - Fee Related ES9100003A1 (es) 1984-12-21 1986-07-15 Un procedimiento para la preparacion de oxetanonas.

Country Status (5)

Country Link
JP (1) JPS61152663A (es)
KR (1) KR950008310B1 (es)
ES (1) ES9100003A1 (es)
GR (1) GR853048B (es)
ZA (1) ZA859575B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013249293A (ja) * 2012-06-04 2013-12-12 Kao Corp リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤
CA3130061A1 (en) * 2013-04-04 2014-10-09 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CA2963815A1 (en) 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
CA3069526A1 (en) 2017-07-12 2019-01-17 Mayo Foundation For Medical Education And Research Compounds for the reducing lipotoxic damage

Also Published As

Publication number Publication date
ES556896A0 (es) 1991-01-01
JPS61152663A (ja) 1986-07-11
JPH0529226B2 (es) 1993-04-28
ZA859575B (en) 1986-08-27
KR860004865A (ko) 1986-07-14
KR950008310B1 (ko) 1995-07-27
GR853048B (es) 1986-04-22

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20151230