CS215142B2 - Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers - Google Patents

Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers Download PDF

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Publication number
CS215142B2
CS215142B2 CS806756A CS675680A CS215142B2 CS 215142 B2 CS215142 B2 CS 215142B2 CS 806756 A CS806756 A CS 806756A CS 675680 A CS675680 A CS 675680A CS 215142 B2 CS215142 B2 CS 215142B2
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CS
Czechoslovakia
Prior art keywords
compound
acid
mol
mixture
solvate
Prior art date
Application number
CS806756A
Other languages
Czech (cs)
English (en)
Inventor
Billy G Jackson
Donna Gardner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS215142B2 publication Critical patent/CS215142B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS806756A 1979-10-09 1980-10-07 Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers CS215142B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid

Publications (1)

Publication Number Publication Date
CS215142B2 true CS215142B2 (en) 1982-07-30

Family

ID=22173679

Family Applications (1)

Application Number Title Priority Date Filing Date
CS806756A CS215142B2 (en) 1979-10-09 1980-10-07 Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers

Country Status (27)

Country Link
US (1) US4252951A (ro)
EP (1) EP0027050B1 (ro)
JP (1) JPS5661388A (ro)
KR (1) KR840000866B1 (ro)
AT (1) AT369008B (ro)
AU (1) AU6306180A (ro)
BE (1) BE885569A (ro)
CA (1) CA1146539A (ro)
CH (1) CH647523A5 (ro)
CS (1) CS215142B2 (ro)
DD (1) DD153375A5 (ro)
DE (1) DE3065181D1 (ro)
DK (1) DK424680A (ro)
ES (1) ES8201166A1 (ro)
FI (1) FI803200L (ro)
FR (1) FR2467211A1 (ro)
GB (1) GB2059966B (ro)
GR (1) GR70219B (ro)
HU (1) HU183230B (ro)
IE (1) IE50390B1 (ro)
IL (1) IL61227A (ro)
IT (1) IT1132926B (ro)
PH (1) PH15023A (ro)
PT (1) PT71886B (ro)
RO (1) RO80664B (ro)
YU (1) YU256480A (ro)
ZA (1) ZA806192B (ro)

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TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
EP2433628A1 (en) * 2005-02-25 2012-03-28 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer
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DK1917253T3 (da) * 2005-08-15 2015-03-30 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af betamimetika
JP5102771B2 (ja) * 2005-10-28 2012-12-19 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼとしての化合物および組成物
WO2007063286A2 (en) * 2005-11-29 2007-06-07 Hammersmith Imanet Limited Amidine derivatives for in vivo imaging
ES2288107B1 (es) * 2006-01-27 2008-11-01 Fundacion Imabis Instituto Mediterraneo Para El Avance De La Biotecnologia Y La Investigacion Sanita Derivados aciclicos saturados e insaturados de cadena larga de sulfamidas como activadores especificos de receptores ppar-alfa.
FR2902996B1 (fr) * 2006-07-03 2008-09-26 Oreal Compositions cosmetiques associant un derive c-glycoside et un derive n-acylaminoamide
FR2903004B1 (fr) * 2006-07-03 2009-07-10 Oreal Utilisation en cosmetique d'un derive c-glycoside en association avec de l'acide ascorbique
US20090075935A1 (en) * 2006-07-03 2009-03-19 L'oreal Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
FR2902999B1 (fr) * 2006-07-03 2012-09-28 Oreal Utilisation de derives c-glycoside a titre d'actif prodesquamant
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Also Published As

Publication number Publication date
GB2059966A (en) 1981-04-29
DE3065181D1 (en) 1983-11-10
KR840000866B1 (ko) 1984-06-20
FI803200A7 (fi) 1981-04-10
GB2059966B (en) 1983-09-01
AT369008B (de) 1982-11-25
IE50390B1 (en) 1986-04-16
AU6306180A (en) 1981-04-16
DD153375A5 (de) 1982-01-06
IL61227A0 (en) 1980-12-31
HU183230B (en) 1984-04-28
FI803200L (fi) 1981-04-10
ZA806192B (en) 1982-05-26
EP0027050A1 (en) 1981-04-15
KR830004314A (ko) 1983-07-09
PT71886B (en) 1981-08-13
US4252951A (en) 1981-02-24
JPS5661388A (en) 1981-05-26
YU256480A (en) 1983-02-28
RO80664A (ro) 1983-02-15
IE802086L (en) 1981-04-09
EP0027050B1 (en) 1983-10-05
CA1146539A (en) 1983-05-17
DK424680A (da) 1981-04-10
PT71886A (en) 1980-11-01
CH647523A5 (fr) 1985-01-31
GR70219B (ro) 1982-08-31
IT8025200A0 (it) 1980-10-08
ES495753A0 (es) 1981-12-01
PH15023A (en) 1982-05-13
ES8201166A1 (es) 1981-12-01
BE885569A (fr) 1981-04-08
FR2467211B1 (ro) 1983-06-10
FR2467211A1 (fr) 1981-04-17
RO80664B (ro) 1983-02-28
IT1132926B (it) 1986-07-09
IL61227A (en) 1983-07-31
ATA498080A (de) 1982-04-15

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