CS208724B2 - Method of making the 5-(2-furoyl)-,5-(2-thonoyl)-,5-(3-furoyl) a 5-(3-thenoyl)-1,2-dihydro-3h-pyrrol/1,2-a/pyrrol-1-karboxyl acid derivatives - Google Patents

Method of making the 5-(2-furoyl)-,5-(2-thonoyl)-,5-(3-furoyl) a 5-(3-thenoyl)-1,2-dihydro-3h-pyrrol/1,2-a/pyrrol-1-karboxyl acid derivatives Download PDF

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Publication number
CS208724B2
CS208724B2 CS774647A CS464777A CS208724B2 CS 208724 B2 CS208724 B2 CS 208724B2 CS 774647 A CS774647 A CS 774647A CS 464777 A CS464777 A CS 464777A CS 208724 B2 CS208724 B2 CS 208724B2
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CS
Czechoslovakia
Prior art keywords
pyrrole
formula
dihydro
carboxylic acid
compounds
Prior art date
Application number
CS774647A
Other languages
Czech (cs)
English (en)
Inventor
Joseph M Muchowski
Arthur F Klugo
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/771,283 external-priority patent/US4087539A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of CS208724B2 publication Critical patent/CS208724B2/cs

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS774647A 1976-07-14 1977-07-12 Method of making the 5-(2-furoyl)-,5-(2-thonoyl)-,5-(3-furoyl) a 5-(3-thenoyl)-1,2-dihydro-3h-pyrrol/1,2-a/pyrrol-1-karboxyl acid derivatives CS208724B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70485776A 1976-07-14 1976-07-14
US05/771,283 US4087539A (en) 1976-07-14 1977-02-23 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (1)

Publication Number Publication Date
CS208724B2 true CS208724B2 (en) 1981-09-15

Family

ID=27107392

Family Applications (1)

Application Number Title Priority Date Filing Date
CS774647A CS208724B2 (en) 1976-07-14 1977-07-12 Method of making the 5-(2-furoyl)-,5-(2-thonoyl)-,5-(3-furoyl) a 5-(3-thenoyl)-1,2-dihydro-3h-pyrrol/1,2-a/pyrrol-1-karboxyl acid derivatives

Country Status (26)

Country Link
JP (1) JPS539789A (es)
AR (1) AR218631A1 (es)
AU (1) AU513385B2 (es)
CA (1) CA1100140A (es)
CH (2) CH644861A5 (es)
CS (1) CS208724B2 (es)
DE (1) DE2731662A1 (es)
DK (1) DK152652C (es)
ES (2) ES460705A1 (es)
FI (1) FI63407C (es)
FR (1) FR2361396A1 (es)
GB (1) GB1554076A (es)
GR (1) GR61607B (es)
HK (1) HK17581A (es)
IE (1) IE45302B1 (es)
IL (1) IL52492A (es)
IT (1) IT1117314B (es)
MY (1) MY8100371A (es)
NL (1) NL7707652A (es)
NO (1) NO147563C (es)
NZ (1) NZ184611A (es)
PL (1) PL111408B1 (es)
PT (1) PT66779B (es)
SE (1) SE434644B (es)
SU (2) SU664566A3 (es)
YU (2) YU43157B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク エンド カムパニー インコーポレーテツド 抗炎症剤および鎮痛剤として新規な5−(ピロ−ル−2−オイル)−1,2−ジヒドロ−3H−ピロロ〔1,2−a〕ピロ−ル誘導体
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds

Also Published As

Publication number Publication date
FR2361396A1 (fr) 1978-03-10
FI63407C (fi) 1983-06-10
YU47583A (en) 1984-06-30
SU793400A3 (ru) 1980-12-30
ES470213A1 (es) 1979-09-16
JPS6254110B2 (es) 1987-11-13
GB1554076A (en) 1979-10-17
SE7708142L (sv) 1978-01-15
FI772154A (es) 1978-01-15
CH644861A5 (en) 1984-08-31
AU2697677A (en) 1979-01-18
YU47683A (en) 1984-04-30
AU513385B2 (en) 1980-11-27
NO147563C (no) 1983-05-18
DK152652B (da) 1988-04-05
DK152652C (da) 1988-09-12
ES460705A1 (es) 1979-10-01
NL7707652A (nl) 1978-01-17
PT66779A (fr) 1977-08-01
DK307677A (da) 1978-01-15
SE434644B (sv) 1984-08-06
NZ184611A (en) 1979-03-28
SU664566A3 (ru) 1979-05-25
NO147563B (no) 1983-01-24
IE45302B1 (en) 1982-07-28
NO772493L (no) 1978-01-17
DE2731662A1 (de) 1978-01-19
PT66779B (fr) 1978-12-18
PL199602A1 (pl) 1979-01-29
GR61607B (en) 1978-12-02
DE2731662C2 (es) 1989-11-09
IL52492A0 (en) 1977-10-31
IT1117314B (it) 1986-02-17
FR2361396B1 (es) 1981-11-27
JPS539789A (en) 1978-01-28
IE45302L (en) 1978-01-14
MY8100371A (en) 1981-12-31
YU43156B (en) 1989-04-30
PL111408B1 (en) 1980-08-30
CH651045A5 (en) 1985-08-30
FI63407B (fi) 1983-02-28
CA1100140A (en) 1981-04-28
YU43157B (en) 1989-04-30
AR218631A1 (es) 1980-06-30
IL52492A (en) 1981-06-29
HK17581A (en) 1981-05-08

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