CS204011B2 - Process for preparing substituted pentapeptides - Google Patents

Process for preparing substituted pentapeptides Download PDF

Info

Publication number
CS204011B2
CS204011B2 CS776044A CS604477A CS204011B2 CS 204011 B2 CS204011 B2 CS 204011B2 CS 776044 A CS776044 A CS 776044A CS 604477 A CS604477 A CS 604477A CS 204011 B2 CS204011 B2 CS 204011B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
alanyl
tyrosyl
phenylalanyl
glycyl
Prior art date
Application number
CS776044A
Other languages
Czech (cs)
English (en)
Inventor
Edward L Smithwick
Robert C A Frederickson
Robert T Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS204011B2 publication Critical patent/CS204011B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS776044A 1976-09-27 1977-09-16 Process for preparing substituted pentapeptides CS204011B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72672476A 1976-09-27 1976-09-27
US05/807,849 US4259234A (en) 1976-09-27 1977-06-20 Analgesic compounds

Publications (1)

Publication Number Publication Date
CS204011B2 true CS204011B2 (en) 1981-03-31

Family

ID=27111374

Family Applications (1)

Application Number Title Priority Date Filing Date
CS776044A CS204011B2 (en) 1976-09-27 1977-09-16 Process for preparing substituted pentapeptides

Country Status (27)

Country Link
US (1) US4259234A (ro)
JP (1) JPS5340736A (ro)
AR (1) AR228937A1 (ro)
AT (1) AT359219B (ro)
AU (1) AU513702B2 (ro)
CA (1) CA1201710A (ro)
CH (2) CH636847A5 (ro)
CS (1) CS204011B2 (ro)
DD (1) DD132862A5 (ro)
DE (1) DE2741393A1 (ro)
DK (1) DK148904C (ro)
ES (1) ES462658A1 (ro)
FR (1) FR2365553A1 (ro)
GB (1) GB1586521A (ro)
GR (1) GR69224B (ro)
HK (1) HK52681A (ro)
HU (1) HU180723B (ro)
IE (1) IE45576B1 (ro)
IL (1) IL52872A (ro)
MY (1) MY8200150A (ro)
NL (1) NL7710502A (ro)
NZ (1) NZ185084A (ro)
PL (1) PL111136B1 (ro)
PT (1) PT67026B (ro)
RO (1) RO80379B (ro)
SE (1) SE438339B (ro)
SU (1) SU753358A3 (ro)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261888A (en) * 1976-04-12 1981-04-14 Sandoz Ltd. Organic compounds
ZA775285B (en) * 1976-09-01 1978-07-26 A Kastin Novel methionine enkephalin derivatives
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4322342A (en) * 1977-06-20 1982-03-30 Eli Lilly And Company Analgesic compounds
EP0000559B1 (en) * 1977-07-22 1983-10-05 The Wellcome Foundation Limited Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them
US4264491A (en) * 1977-10-03 1981-04-28 Eli Lilly And Company Analgesic compounds
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
DE2933947A1 (de) * 1979-08-22 1981-03-12 Hoechst Ag, 6000 Frankfurt Neue peptidamide und verfahren zu ihrer herstellung.
US4254024A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Tetrapeptides and derivatives having opiate activity
US4351763A (en) * 1979-12-17 1982-09-28 Eli Lilly And Company Pharmacologically active peptides
US4283329A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
US4265808A (en) * 1979-12-17 1981-05-05 Eli Lilly And Company Pharmacologically active peptides
US4251439A (en) * 1979-12-17 1981-02-17 Eli Lilly And Company Pharmacologically active peptides
US4283330A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
US4322339A (en) * 1980-10-20 1982-03-30 Eli Lilly And Company Pharmacologically active peptides
ATE16495T1 (de) * 1981-06-22 1985-11-15 Ici Plc Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.
US4430327A (en) 1982-05-18 1984-02-07 Eli Lilly And Company Method for treating pregnant females for pain and anxiety
DE3915755A1 (de) * 1989-05-13 1990-11-29 Bayer Ag Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
DE4102042A1 (de) * 1991-01-24 1992-07-30 Bayer Ag Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
JPH09173654A (ja) * 1995-12-21 1997-07-08 Ritsuwa Yo 積 木
EP1297830A1 (en) * 2001-09-28 2003-04-02 Flamma Fabbrica Lombarda Ammino Acidi S.p.a. Use of alpha- or beta-amino acids, of the corresponding esters or of dipeptides of these amino acids with histidine derivatives in the prevention or treatment of tissue damage caused by a atmospheric ozone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532181A (en) * 1976-02-02 1978-11-15 Beckman Instruments Inc Pentapetides and a method of preparing them
FI770219A (ro) * 1976-02-02 1977-08-03 Sandoz Ag
NZ183712A (en) * 1976-04-08 1979-10-25 Ici Ltd Polypeptide analogues of enkephalins, and pharmaceutical compositions
ZA775285B (en) * 1976-09-01 1978-07-26 A Kastin Novel methionine enkephalin derivatives
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4178371A (en) * 1977-12-15 1979-12-11 Reckitt & Colman Products Limited Tetrapeptide derivatives

Also Published As

Publication number Publication date
SU753358A3 (ru) 1980-07-30
AU513702B2 (en) 1980-12-18
NZ185084A (en) 1980-11-14
MY8200150A (en) 1982-12-31
GB1586521A (en) 1981-03-18
DK424577A (da) 1978-03-28
CH643533A5 (de) 1984-06-15
ES462658A1 (es) 1978-11-01
RO80379B (ro) 1983-04-30
CA1201710A (en) 1986-03-11
ATA685977A (de) 1980-03-15
AU2856577A (en) 1979-03-15
AR228937A1 (es) 1983-05-13
DD132862A5 (de) 1978-11-15
PL201049A1 (pl) 1979-01-29
CH636847A5 (de) 1983-06-30
IL52872A (en) 1983-07-31
DK148904C (da) 1986-04-14
PT67026B (en) 1979-02-14
FR2365553B1 (ro) 1980-11-14
AT359219B (de) 1980-10-27
RO80379A (ro) 1983-04-29
HU180723B (en) 1983-04-29
PT67026A (en) 1977-10-01
SE438339B (sv) 1985-04-15
IE45576B1 (en) 1982-10-06
DK148904B (da) 1985-11-11
DE2741393C2 (ro) 1988-03-10
DE2741393A1 (de) 1978-03-30
JPS6254800B2 (ro) 1987-11-17
JPS5340736A (en) 1978-04-13
US4259234A (en) 1981-03-31
SE7710755L (sv) 1978-03-28
PL111136B1 (en) 1980-08-30
HK52681A (en) 1981-11-06
NL7710502A (nl) 1978-03-29
IE45576L (en) 1978-03-27
GR69224B (ro) 1982-05-10
FR2365553A1 (fr) 1978-04-21

Similar Documents

Publication Publication Date Title
CS204011B2 (en) Process for preparing substituted pentapeptides
US5317014A (en) Peptides and pseudopeptides derived from tachykinin
US3832337A (en) Peptide enzyme inhibitors
US4472305A (en) Hexapeptide amides
CA2301687A1 (en) Phenethylamine derivatives
JPH11292840A (ja) ノルスタチン誘導体又はその塩
US3740385A (en) N-terminal derivatives of secretin
KR0121793B1 (ko) L-프롤린 유도체, 이의 제조 방법 및 이를 함유하는 향정신성 생물학적 제제
EP0001684B1 (en) Tetrapeptides, methods for their preparation and their use in analgesic compositions
US6184345B1 (en) Branched building units for synthesizing cyclic peptides
US20240124517A1 (en) Method for producing peptide compound containing n-substituted-amino acid residue
US4407746A (en) Cyclohexyl and phenyl substituted enkephalins
NZ198626A (en) Peptides and pharmaceutical compositions
US4322342A (en) Analgesic compounds
US4092304A (en) 4-Substituted enkephalin derivatives
Siemion et al. To the problem of biologically active conformation of enkephalin
HU185022B (en) Process for the preparation of biologically active tetrapeptide derivatives
US5503989A (en) Production of peptide amides
US4491541A (en) Peptides
WO1993000359A1 (en) Modified peptides transportable into the central nervous system
HU190915B (en) Process for preparing new tripeptide derivatives
CA1178950A (en) Preparation of (d-trp.sup.6)-lh-rh via the heptapeptide h-ser-tyr-d-trp-leu-arg-pro-gly- nh.sub.2
GB2130590A (en) Peptides
JP2001505216A (ja) ブラジキニンｂ▲下２▼レセプターのペプチドアゴニスト
Ohno et al. Partial enzymic deprotection in the synthesis of a protected octapeptide bearing a free terminal carboxyl group