DK148904C - Analogifremgangsmaade til fremstilling af analgetisk virksomme enkephalin-analoge pentapeptidamider eller farmaceutisk acceptable, ikke-toxiske syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af analgetisk virksomme enkephalin-analoge pentapeptidamider eller farmaceutisk acceptable, ikke-toxiske syreadditionssalte deraf

Info

Publication number
DK148904C
DK148904C DK424577A DK424577A DK148904C DK 148904 C DK148904 C DK 148904C DK 424577 A DK424577 A DK 424577A DK 424577 A DK424577 A DK 424577A DK 148904 C DK148904 C DK 148904C
Authority
DK
Denmark
Prior art keywords
analogue
pentapeptidamides
preparation
acid addition
addition salts
Prior art date
Application number
DK424577A
Other languages
English (en)
Other versions
DK148904B (da
DK424577A (da
Inventor
Jr Edward Lee Smithwick
Robert Curtis Art Frederickson
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK424577A publication Critical patent/DK424577A/da
Publication of DK148904B publication Critical patent/DK148904B/da
Application granted granted Critical
Publication of DK148904C publication Critical patent/DK148904C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK424577A 1976-09-27 1977-09-26 Analogifremgangsmaade til fremstilling af analgetisk virksomme enkephalin-analoge pentapeptidamider eller farmaceutisk acceptable, ikke-toxiske syreadditionssalte deraf DK148904C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72672476A 1976-09-27 1976-09-27
US72672476 1976-09-27
US80784977 1977-06-20
US05/807,849 US4259234A (en) 1976-09-27 1977-06-20 Analgesic compounds

Publications (3)

Publication Number Publication Date
DK424577A DK424577A (da) 1978-03-28
DK148904B DK148904B (da) 1985-11-11
DK148904C true DK148904C (da) 1986-04-14

Family

ID=27111374

Family Applications (1)

Application Number Title Priority Date Filing Date
DK424577A DK148904C (da) 1976-09-27 1977-09-26 Analogifremgangsmaade til fremstilling af analgetisk virksomme enkephalin-analoge pentapeptidamider eller farmaceutisk acceptable, ikke-toxiske syreadditionssalte deraf

Country Status (27)

Country Link
US (1) US4259234A (da)
JP (1) JPS5340736A (da)
AR (1) AR228937A1 (da)
AT (1) AT359219B (da)
AU (1) AU513702B2 (da)
CA (1) CA1201710A (da)
CH (2) CH636847A5 (da)
CS (1) CS204011B2 (da)
DD (1) DD132862A5 (da)
DE (1) DE2741393A1 (da)
DK (1) DK148904C (da)
ES (1) ES462658A1 (da)
FR (1) FR2365553A1 (da)
GB (1) GB1586521A (da)
GR (1) GR69224B (da)
HK (1) HK52681A (da)
HU (1) HU180723B (da)
IE (1) IE45576B1 (da)
IL (1) IL52872A (da)
MY (1) MY8200150A (da)
NL (1) NL7710502A (da)
NZ (1) NZ185084A (da)
PL (1) PL111136B1 (da)
PT (1) PT67026B (da)
RO (1) RO80379B (da)
SE (1) SE438339B (da)
SU (1) SU753358A3 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261888A (en) * 1976-04-12 1981-04-14 Sandoz Ltd. Organic compounds
SE7709806L (sv) * 1976-09-01 1978-03-02 Coy David Howard Forfarande for framstellning av peptider
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4322342A (en) * 1977-06-20 1982-03-30 Eli Lilly And Company Analgesic compounds
JPS5424850A (en) * 1977-07-22 1979-02-24 Wellcome Found Peptide compound
US4264491A (en) * 1977-10-03 1981-04-28 Eli Lilly And Company Analgesic compounds
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
DE2933947A1 (de) * 1979-08-22 1981-03-12 Hoechst Ag, 6000 Frankfurt Neue peptidamide und verfahren zu ihrer herstellung.
US4254024A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Tetrapeptides and derivatives having opiate activity
US4265808A (en) * 1979-12-17 1981-05-05 Eli Lilly And Company Pharmacologically active peptides
US4351763A (en) * 1979-12-17 1982-09-28 Eli Lilly And Company Pharmacologically active peptides
US4283330A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
US4251439A (en) * 1979-12-17 1981-02-17 Eli Lilly And Company Pharmacologically active peptides
US4283329A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
US4322339A (en) * 1980-10-20 1982-03-30 Eli Lilly And Company Pharmacologically active peptides
EP0076557B1 (en) * 1981-06-22 1985-11-13 Imperial Chemical Industries Plc Peptides and pseudopeptides in which the n terminus bears two substituents
US4430327A (en) 1982-05-18 1984-02-07 Eli Lilly And Company Method for treating pregnant females for pain and anxiety
DE3915755A1 (de) * 1989-05-13 1990-11-29 Bayer Ag Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
DE4102042A1 (de) * 1991-01-24 1992-07-30 Bayer Ag Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
JPH09173654A (ja) * 1995-12-21 1997-07-08 Ritsuwa Yo 積 木
EP1297830A1 (en) * 2001-09-28 2003-04-02 Flamma Fabbrica Lombarda Ammino Acidi S.p.a. Use of alpha- or beta-amino acids, of the corresponding esters or of dipeptides of these amino acids with histidine derivatives in the prevention or treatment of tissue damage caused by a atmospheric ozone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532181A (en) * 1976-02-02 1978-11-15 Beckman Instruments Inc Pentapetides and a method of preparing them
DK28377A (da) * 1976-02-02 1977-08-03 Sandoz Ag Fremgangsmade til fremstilling af polypeptidderivater
NZ183712A (en) * 1976-04-08 1979-10-25 Ici Ltd Polypeptide analogues of enkephalins, and pharmaceutical compositions
SE7709806L (sv) * 1976-09-01 1978-03-02 Coy David Howard Forfarande for framstellning av peptider
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4178371A (en) * 1977-12-15 1979-12-11 Reckitt & Colman Products Limited Tetrapeptide derivatives

Also Published As

Publication number Publication date
PT67026A (en) 1977-10-01
GR69224B (da) 1982-05-10
DD132862A5 (de) 1978-11-15
ES462658A1 (es) 1978-11-01
IE45576B1 (en) 1982-10-06
PT67026B (en) 1979-02-14
FR2365553A1 (fr) 1978-04-21
ATA685977A (de) 1980-03-15
CH636847A5 (de) 1983-06-30
GB1586521A (en) 1981-03-18
FR2365553B1 (da) 1980-11-14
MY8200150A (en) 1982-12-31
DK148904B (da) 1985-11-11
PL111136B1 (en) 1980-08-30
IE45576L (en) 1978-03-27
IL52872A (en) 1983-07-31
AR228937A1 (es) 1983-05-13
JPS6254800B2 (da) 1987-11-17
HK52681A (en) 1981-11-06
AU513702B2 (en) 1980-12-18
NL7710502A (nl) 1978-03-29
PL201049A1 (pl) 1979-01-29
CH643533A5 (de) 1984-06-15
SE438339B (sv) 1985-04-15
CA1201710A (en) 1986-03-11
DE2741393C2 (da) 1988-03-10
DK424577A (da) 1978-03-28
CS204011B2 (en) 1981-03-31
AU2856577A (en) 1979-03-15
RO80379A (ro) 1983-04-29
JPS5340736A (en) 1978-04-13
SE7710755L (sv) 1978-03-28
RO80379B (ro) 1983-04-30
US4259234A (en) 1981-03-31
SU753358A3 (ru) 1980-07-30
DE2741393A1 (de) 1978-03-30
AT359219B (de) 1980-10-27
HU180723B (en) 1983-04-29
NZ185084A (en) 1980-11-14

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