RO80379B - Procedeu pentru prepararea unor pentapeptide - Google Patents

Procedeu pentru prepararea unor pentapeptide

Info

Publication number
RO80379B
RO80379B RO91664A RO9166477A RO80379B RO 80379 B RO80379 B RO 80379B RO 91664 A RO91664 A RO 91664A RO 9166477 A RO9166477 A RO 9166477A RO 80379 B RO80379 B RO 80379B
Authority
RO
Romania
Prior art keywords
alkyl group
primary
group
hydrogen
sulfur atom
Prior art date
Application number
RO91664A
Other languages
English (en)
Other versions
RO80379A (ro
Inventor
Edward Lee Smithwick Jr.
Robert Curtis Arthur Frederickson
Robert Theodore Shumann
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO80379A publication Critical patent/RO80379A/ro
Publication of RO80379B publication Critical patent/RO80379B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Procedeu pentru prepararea unui compus cu formula generala I: (vezi form. in desc.) în care L si D, atunci cînd este cazul, definesc chiar realitatea; R1 reprezinta hidrogen, o grupa C1-C3 alchil primara sau alil; R2 reprezinta hidrogen sau o grupa C1-C3 alalchil primara; R4 reprezinta o grupa C1-C4 alchil primara sau secundara; R5 reprezinta hidrogen sau o grupa C1-C4 alchil primara sau secundara; R6 reprezinta hidrogen sau o grupa C1-C3 alchil primara; R7 reprezinta o grupa C1-C3 alchil primara; Y reprezinta un atom de hidrogen sau o grupa acetil; Z reprezinta o grupa-C(0)-NHR8 în care R8 reprezinta hidrogen sau o grupa C1-C3 alchil; W este o grupa izopropil, VR9 sau -CH2-X-CH3 în care V reprezinta un atom de oxigen sau de sulf , R9 reprezinta o grupa C1-C4 alchil sau o grupa aralchil si X reprezinta un atom de oxigen sau de sulf sau grupa -CH2- cu conditia ca atunci cind W reprezinta -VR9, în care V reprezinta un atom de sulf .......
RO91664A 1976-09-27 1977-09-26 Procedeu pentru prepararea unor pentapeptide RO80379B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72672476A 1976-09-27 1976-09-27
US05/807,849 US4259234A (en) 1976-09-27 1977-06-20 Analgesic compounds

Publications (2)

Publication Number Publication Date
RO80379A RO80379A (ro) 1983-04-29
RO80379B true RO80379B (ro) 1983-04-30

Family

ID=27111374

Family Applications (1)

Application Number Title Priority Date Filing Date
RO91664A RO80379B (ro) 1976-09-27 1977-09-26 Procedeu pentru prepararea unor pentapeptide

Country Status (27)

Country Link
US (1) US4259234A (ro)
JP (1) JPS5340736A (ro)
AR (1) AR228937A1 (ro)
AT (1) AT359219B (ro)
AU (1) AU513702B2 (ro)
CA (1) CA1201710A (ro)
CH (2) CH636847A5 (ro)
CS (1) CS204011B2 (ro)
DD (1) DD132862A5 (ro)
DE (1) DE2741393A1 (ro)
DK (1) DK148904C (ro)
ES (1) ES462658A1 (ro)
FR (1) FR2365553A1 (ro)
GB (1) GB1586521A (ro)
GR (1) GR69224B (ro)
HK (1) HK52681A (ro)
HU (1) HU180723B (ro)
IE (1) IE45576B1 (ro)
IL (1) IL52872A (ro)
MY (1) MY8200150A (ro)
NL (1) NL7710502A (ro)
NZ (1) NZ185084A (ro)
PL (1) PL111136B1 (ro)
PT (1) PT67026B (ro)
RO (1) RO80379B (ro)
SE (1) SE438339B (ro)
SU (1) SU753358A3 (ro)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261888A (en) * 1976-04-12 1981-04-14 Sandoz Ltd. Organic compounds
PT66982B (en) * 1976-09-01 1979-02-13 Coy David Howard Process for preparing novel methionine enkephalin derivatives
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4322342A (en) * 1977-06-20 1982-03-30 Eli Lilly And Company Analgesic compounds
EP0000559B1 (en) * 1977-07-22 1983-10-05 The Wellcome Foundation Limited Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them
US4264491A (en) * 1977-10-03 1981-04-28 Eli Lilly And Company Analgesic compounds
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
DE2933947A1 (de) * 1979-08-22 1981-03-12 Hoechst Ag, 6000 Frankfurt Neue peptidamide und verfahren zu ihrer herstellung.
US4254024A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Tetrapeptides and derivatives having opiate activity
US4351763A (en) * 1979-12-17 1982-09-28 Eli Lilly And Company Pharmacologically active peptides
US4265808A (en) * 1979-12-17 1981-05-05 Eli Lilly And Company Pharmacologically active peptides
US4283330A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
US4251439A (en) * 1979-12-17 1981-02-17 Eli Lilly And Company Pharmacologically active peptides
US4283329A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
US4322339A (en) * 1980-10-20 1982-03-30 Eli Lilly And Company Pharmacologically active peptides
ATE16495T1 (de) * 1981-06-22 1985-11-15 Ici Plc Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.
US4430327A (en) 1982-05-18 1984-02-07 Eli Lilly And Company Method for treating pregnant females for pain and anxiety
DE3915755A1 (de) * 1989-05-13 1990-11-29 Bayer Ag Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
DE4102042A1 (de) * 1991-01-24 1992-07-30 Bayer Ag Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
JPH09173654A (ja) * 1995-12-21 1997-07-08 Ritsuwa Yo 積 木
EP1297830A1 (en) * 2001-09-28 2003-04-02 Flamma Fabbrica Lombarda Ammino Acidi S.p.a. Use of alpha- or beta-amino acids, of the corresponding esters or of dipeptides of these amino acids with histidine derivatives in the prevention or treatment of tissue damage caused by a atmospheric ozone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532181A (en) * 1976-02-02 1978-11-15 Beckman Instruments Inc Pentapetides and a method of preparing them
FI770219A (ro) * 1976-02-02 1977-08-03 Sandoz Ag
NZ183712A (en) * 1976-04-08 1979-10-25 Ici Ltd Polypeptide analogues of enkephalins, and pharmaceutical compositions
PT66982B (en) * 1976-09-01 1979-02-13 Coy David Howard Process for preparing novel methionine enkephalin derivatives
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4178371A (en) * 1977-12-15 1979-12-11 Reckitt & Colman Products Limited Tetrapeptide derivatives

Also Published As

Publication number Publication date
SE7710755L (sv) 1978-03-28
IE45576L (en) 1978-03-27
PT67026B (en) 1979-02-14
FR2365553B1 (ro) 1980-11-14
US4259234A (en) 1981-03-31
NL7710502A (nl) 1978-03-29
ES462658A1 (es) 1978-11-01
CS204011B2 (en) 1981-03-31
CH643533A5 (de) 1984-06-15
DE2741393A1 (de) 1978-03-30
HK52681A (en) 1981-11-06
SE438339B (sv) 1985-04-15
DK148904B (da) 1985-11-11
IE45576B1 (en) 1982-10-06
HU180723B (en) 1983-04-29
PL111136B1 (en) 1980-08-30
JPS6254800B2 (ro) 1987-11-17
JPS5340736A (en) 1978-04-13
AT359219B (de) 1980-10-27
NZ185084A (en) 1980-11-14
AU2856577A (en) 1979-03-15
GB1586521A (en) 1981-03-18
AU513702B2 (en) 1980-12-18
GR69224B (ro) 1982-05-10
DK424577A (da) 1978-03-28
CH636847A5 (de) 1983-06-30
FR2365553A1 (fr) 1978-04-21
RO80379A (ro) 1983-04-29
AR228937A1 (es) 1983-05-13
DD132862A5 (de) 1978-11-15
ATA685977A (de) 1980-03-15
PT67026A (en) 1977-10-01
PL201049A1 (pl) 1979-01-29
MY8200150A (en) 1982-12-31
CA1201710A (en) 1986-03-11
SU753358A3 (ru) 1980-07-30
IL52872A (en) 1983-07-31
DE2741393C2 (ro) 1988-03-10
DK148904C (da) 1986-04-14

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