CS203135B2 - Method of producing racemic or optically active pyrimido/1,2a/heterocyclic compounds - Google Patents

Method of producing racemic or optically active pyrimido/1,2a/heterocyclic compounds Download PDF

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Publication number
CS203135B2
CS203135B2 CS767665A CS766576A CS203135B2 CS 203135 B2 CS203135 B2 CS 203135B2 CS 767665 A CS767665 A CS 767665A CS 766576 A CS766576 A CS 766576A CS 203135 B2 CS203135 B2 CS 203135B2
Authority
CS
Czechoslovakia
Prior art keywords
alkyl
alkali metal
formula
optically active
metal carbonate
Prior art date
Application number
CS767665A
Other languages
Czech (cs)
English (en)
Inventor
Zoltan Meszaros
Jozsef Knoll
Peter Szentmiklosi
Istvan Hermecz
Agnes Horvath
Sandor Virag
Lelle Vasvari
Agoston David
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to CS78543A priority Critical patent/CS203136B2/cs
Publication of CS203135B2 publication Critical patent/CS203135B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS767665A 1975-11-27 1976-11-26 Method of producing racemic or optically active pyrimido/1,2a/heterocyclic compounds CS203135B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS78543A CS203136B2 (cs) 1975-11-27 1978-01-26 Způsob výroby racemických nebo opticky aktivních pyrimido[1,2a]- heterocyklických sloučenin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU75CI1623A HU173438B (hu) 1975-11-27 1975-11-27 Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Publications (1)

Publication Number Publication Date
CS203135B2 true CS203135B2 (en) 1981-02-27

Family

ID=10994587

Family Applications (1)

Application Number Title Priority Date Filing Date
CS767665A CS203135B2 (en) 1975-11-27 1976-11-26 Method of producing racemic or optically active pyrimido/1,2a/heterocyclic compounds

Country Status (28)

Country Link
US (2) US4460771A (ko)
JP (1) JPS5914033B2 (ko)
AT (1) AT359506B (ko)
AU (1) AU512256B2 (ko)
BE (1) BE848868A (ko)
BG (1) BG31226A4 (ko)
CA (1) CA1088531A (ko)
CH (2) CH630378A5 (ko)
CS (1) CS203135B2 (ko)
DD (1) DD130431A5 (ko)
DE (1) DE2653257A1 (ko)
DK (1) DK153150C (ko)
EG (1) EG12495A (ko)
ES (1) ES453690A1 (ko)
FI (1) FI62085C (ko)
FR (1) FR2332755A1 (ko)
GB (1) GB1531963A (ko)
GR (1) GR61820B (ko)
HU (1) HU173438B (ko)
IL (1) IL50930A (ko)
IN (1) IN148945B (ko)
MX (1) MX5178E (ko)
NL (1) NL188948C (ko)
PL (1) PL109657B1 (ko)
RO (2) RO79705A (ko)
SE (1) SE433353B (ko)
SU (2) SU664565A3 (ko)
YU (2) YU289076A (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180701B (en) * 1977-12-29 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing pyrido-/1,2-a/pyrimidines containing a carboxylic or ester group on the pirimidimering
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
HU183408B (en) * 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
HU186607B (en) * 1982-03-31 1985-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing pharmaceutical composition with synergetic antiinflammatory activity
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4772475A (en) * 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
HU201551B (en) * 1988-02-03 1990-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same
US5252572A (en) * 1988-02-03 1993-10-12 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
JP4498922B2 (ja) * 2002-07-09 2010-07-07 アクテリオン ファーマシューティカルズ リミテッド ７，８，９，１０−テトラヒドロ−６Ｈ−アゼピノ、６，７，８，９−テトラヒドロ−ピリドおよび２，３−ジヒドロ−２Ｈ−ピロロ［２，１−ｂ］−キナゾリノン誘導体
US7772232B2 (en) * 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
US20060111308A1 (en) * 2004-11-16 2006-05-25 Wendye Robbins Methods and compositions for therapeutic treatment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH538494A (de) * 1966-11-02 1973-06-30 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung neuer Homopyrimidazol-Derivate
US3642797A (en) * 1968-06-10 1972-02-15 Sterling Drug Inc 4h-pyrido(1 2-a)pyrimidin-4-ones
HU168014B (ko) * 1973-03-30 1976-02-28
US4209622A (en) * 1973-03-30 1980-06-24 Chinoin Gygyszer es Vegyeszeti Termekek Gyara Rt. 3-(Ethoxycarbonyl-methyl)-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine
HU168541B (ko) * 1973-11-24 1976-05-28
US4022897A (en) * 1974-03-04 1977-05-10 E. R. Squibb & Sons, Inc. CNS active compounds
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4066766A (en) * 1975-03-03 1978-01-03 Pfizer Inc. 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents

Also Published As

Publication number Publication date
GB1531963A (en) 1978-11-15
HU173438B (hu) 1979-05-28
NL188948C (nl) 1992-11-16
CH630378A5 (de) 1982-06-15
NL188948B (nl) 1992-06-16
DD130431A5 (de) 1978-03-29
FI62085C (fi) 1982-11-10
JPS5268198A (en) 1977-06-06
YU147583A (en) 1986-06-30
AU1975976A (en) 1978-05-25
IL50930A (en) 1981-06-29
IN148945B (ko) 1981-07-25
JPS5914033B2 (ja) 1984-04-02
BG31226A4 (en) 1981-11-16
CH630379A5 (de) 1982-06-15
SU664565A3 (ru) 1979-05-25
EG12495A (en) 1980-12-31
AT359506B (de) 1980-11-10
MX5178E (es) 1983-04-20
SU698532A3 (ru) 1979-11-15
US4460771A (en) 1984-07-17
DK153150B (da) 1988-06-20
ES453690A1 (es) 1977-12-01
FI62085B (fi) 1982-07-30
CA1088531A (en) 1980-10-28
FI763401A (ko) 1977-05-28
DK534076A (da) 1977-05-28
BE848868A (fr) 1977-03-16
FR2332755A1 (fr) 1977-06-24
DE2653257A1 (de) 1977-06-02
AU512256B2 (en) 1980-10-02
YU289076A (en) 1983-12-31
DK153150C (da) 1988-10-24
ATA873576A (de) 1980-04-15
SE7613140L (sv) 1977-05-28
DE2653257C2 (ko) 1989-04-20
NL7613140A (nl) 1977-06-01
RO79705A (ro) 1982-08-17
FR2332755B1 (ko) 1978-12-22
US4472398A (en) 1984-09-18
PL109657B1 (en) 1980-06-30
IL50930A0 (en) 1977-01-31
SE433353B (sv) 1984-05-21
GR61820B (en) 1979-01-22
RO73522A (ro) 1981-11-04

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