CS203014B2 - Process for preparing new imidazoquinazolines - Google Patents

Process for preparing new imidazoquinazolines Download PDF

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Publication number
CS203014B2
CS203014B2 CS784914A CS491478A CS203014B2 CS 203014 B2 CS203014 B2 CS 203014B2 CS 784914 A CS784914 A CS 784914A CS 491478 A CS491478 A CS 491478A CS 203014 B2 CS203014 B2 CS 203014B2
Authority
CS
Czechoslovakia
Prior art keywords
ethyl ester
formula
chloro
compound
alanine
Prior art date
Application number
CS784914A
Other languages
Czech (cs)
English (en)
Inventor
Madhukar S Chodnekar
Ado Kaiser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CS203014B2 publication Critical patent/CS203014B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS784914A 1977-07-25 1978-07-24 Process for preparing new imidazoquinazolines CS203014B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
CH577678 1978-05-26

Publications (1)

Publication Number Publication Date
CS203014B2 true CS203014B2 (en) 1981-02-27

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
CS784914A CS203014B2 (en) 1977-07-25 1978-07-24 Process for preparing new imidazoquinazolines

Country Status (29)

Country Link
US (1) US4256748A (de)
EP (1) EP0000718B1 (de)
JP (1) JPS5441894A (de)
AR (1) AR218500A1 (de)
AT (1) AT363479B (de)
AU (1) AU519688B2 (de)
BR (1) BR7804763A (de)
CA (1) CA1094555A (de)
CS (1) CS203014B2 (de)
DE (2) DE2832138A1 (de)
DK (1) DK144128C (de)
ES (2) ES471981A1 (de)
FI (1) FI63409C (de)
FR (1) FR2398748A1 (de)
GB (1) GB2001638B (de)
GR (1) GR72968B (de)
HU (1) HU177643B (de)
IE (1) IE47280B1 (de)
IL (1) IL55183A (de)
IT (1) IT1097337B (de)
MC (1) MC1199A1 (de)
MY (1) MY8500249A (de)
NL (1) NL7807507A (de)
NO (1) NO150800C (de)
NZ (1) NZ187921A (de)
PH (1) PH14642A (de)
PT (1) PT68342A (de)
SE (1) SE7808111L (de)
YU (1) YU177578A (de)

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US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
CZ281628B6 (cs) * 1991-07-29 1996-11-13 Warner-Lambert Company Deriváty chinazolinu a farmaceutické přípravky na jejich bázi
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
EP1225901A2 (de) * 1999-09-21 2002-07-31 Emory University Verwendungen und zusammensetzungen zur behandlung von blutplättchenverwandten krankheiten, mit anagrelide
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
PT1589973E (pt) * 2003-01-23 2010-07-09 Shire Holdings Ag FORMULAÆO E MéTODOS PARA O TRATAMENTO DE TROMBOCITEMIA
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) * 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
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GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
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GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
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GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
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US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
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US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
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US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
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JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
NO150800C (no) 1984-12-27
GR72968B (de) 1984-01-20
IE781478L (en) 1979-01-25
DE2832138A1 (de) 1979-02-08
GB2001638B (en) 1982-02-10
CA1094555A (en) 1981-01-27
NL7807507A (nl) 1979-01-29
US4256748A (en) 1981-03-17
AU3812778A (en) 1980-01-24
IE47280B1 (en) 1984-02-08
FR2398748A1 (fr) 1979-02-23
NO150800B (no) 1984-09-10
HU177643B (en) 1981-11-28
EP0000718A3 (en) 1979-06-13
FR2398748B1 (de) 1981-09-04
EP0000718B1 (de) 1982-03-24
YU177578A (en) 1983-01-21
JPS5441894A (en) 1979-04-03
PH14642A (en) 1981-10-12
MC1199A1 (fr) 1979-03-19
IL55183A0 (en) 1978-09-29
SE7808111L (sv) 1979-01-26
IT1097337B (it) 1985-08-31
PT68342A (en) 1978-08-01
DK144128C (da) 1982-05-17
EP0000718A2 (de) 1979-02-21
FI782248A7 (fi) 1979-01-26
DK328978A (da) 1979-01-26
AR218500A1 (es) 1980-06-13
NZ187921A (en) 1981-03-16
ES476955A1 (es) 1979-10-16
IL55183A (en) 1981-11-30
DK144128B (da) 1981-12-14
FI63409B (fi) 1983-02-28
FI63409C (fi) 1983-06-10
IT7826019A0 (it) 1978-07-24
NO782541L (no) 1979-01-26
ATA535178A (de) 1981-01-15
MY8500249A (en) 1985-12-31
GB2001638A (en) 1979-02-07
AT363479B (de) 1981-08-10
DE2861688D1 (en) 1982-04-29
AU519688B2 (en) 1981-12-17
ES471981A1 (es) 1979-10-16
BR7804763A (pt) 1979-04-10

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