IE47280B1 - Imidazo (2,1-b) quinazolines - Google Patents

Imidazo (2,1-b) quinazolines

Info

Publication number
IE47280B1
IE47280B1 IE1478/78A IE147878A IE47280B1 IE 47280 B1 IE47280 B1 IE 47280B1 IE 1478/78 A IE1478/78 A IE 1478/78A IE 147878 A IE147878 A IE 147878A IE 47280 B1 IE47280 B1 IE 47280B1
Authority
IE
Ireland
Prior art keywords
lower alkyl
ethyl ester
compound
dihydro
imidazo
Prior art date
Application number
IE1478/78A
Other languages
English (en)
Other versions
IE781478L (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE781478L publication Critical patent/IE781478L/xx
Publication of IE47280B1 publication Critical patent/IE47280B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IE1478/78A 1977-07-25 1978-07-24 Imidazo (2,1-b) quinazolines IE47280B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
CH577678 1978-05-26

Publications (2)

Publication Number Publication Date
IE781478L IE781478L (en) 1979-01-25
IE47280B1 true IE47280B1 (en) 1984-02-08

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1478/78A IE47280B1 (en) 1977-07-25 1978-07-24 Imidazo (2,1-b) quinazolines

Country Status (29)

Country Link
US (1) US4256748A (de)
EP (1) EP0000718B1 (de)
JP (1) JPS5441894A (de)
AR (1) AR218500A1 (de)
AT (1) AT363479B (de)
AU (1) AU519688B2 (de)
BR (1) BR7804763A (de)
CA (1) CA1094555A (de)
CS (1) CS203014B2 (de)
DE (2) DE2861688D1 (de)
DK (1) DK144128C (de)
ES (2) ES471981A1 (de)
FI (1) FI63409C (de)
FR (1) FR2398748A1 (de)
GB (1) GB2001638B (de)
GR (1) GR72968B (de)
HU (1) HU177643B (de)
IE (1) IE47280B1 (de)
IL (1) IL55183A (de)
IT (1) IT1097337B (de)
MC (1) MC1199A1 (de)
MY (1) MY8500249A (de)
NL (1) NL7807507A (de)
NO (1) NO150800C (de)
NZ (1) NZ187921A (de)
PH (1) PH14642A (de)
PT (1) PT68342A (de)
SE (1) SE7808111L (de)
YU (1) YU177578A (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
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US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
CA2113115A1 (en) * 1991-07-29 1993-02-18 Vlad E. Gregor Quinazoline derivatives as acetylcholinesterase inhibitors
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
EP1216037A2 (de) * 1999-09-21 2002-06-26 Emory University Verfahren und zusammensetzungen zur behandlung von bluttplätchen-zusammenhängenden krankheiten, mit mpl hemmenden agenten
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
CA2513708C (en) * 2003-01-23 2011-01-04 Shire Holdings Ag Formulation and methods for the treatment of thrombocythemia
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
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GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
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GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0810005D0 (en) * 2008-06-02 2008-07-09 Shire Llc Substituted quinazolines
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GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9580471B2 (en) 2011-03-01 2017-02-28 Synergy Pharmaceuticals, Inc. Process of preparing guanylate cyclase C agonists
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonisten der guanylatcyclase und deren verwendungen
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
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DE1445430A1 (de) 1962-10-26 1969-01-23 American Home Prod Verfahren zur Herstellung von 3-Acyloxy-1,3-dihydro-2 H-1-benzodiazepin-2-onen
GB1037375A (en) 1964-08-07 1966-07-27 Hoffmann La Roche A process for the manufacture of benzodiazepine derivatives
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
NO782541L (no) 1979-01-26
GB2001638B (en) 1982-02-10
ES476955A1 (es) 1979-10-16
IE781478L (en) 1979-01-25
IT1097337B (it) 1985-08-31
GR72968B (de) 1984-01-20
DK144128B (da) 1981-12-14
IL55183A (en) 1981-11-30
FR2398748A1 (fr) 1979-02-23
YU177578A (en) 1983-01-21
NO150800C (no) 1984-12-27
ATA535178A (de) 1981-01-15
FR2398748B1 (de) 1981-09-04
HU177643B (en) 1981-11-28
BR7804763A (pt) 1979-04-10
JPS5441894A (en) 1979-04-03
MY8500249A (en) 1985-12-31
EP0000718A2 (de) 1979-02-21
GB2001638A (en) 1979-02-07
IL55183A0 (en) 1978-09-29
EP0000718A3 (en) 1979-06-13
US4256748A (en) 1981-03-17
DE2832138A1 (de) 1979-02-08
ES471981A1 (es) 1979-10-16
DE2861688D1 (en) 1982-04-29
EP0000718B1 (de) 1982-03-24
NO150800B (no) 1984-09-10
AT363479B (de) 1981-08-10
AU3812778A (en) 1980-01-24
FI782248A (fi) 1979-01-26
IT7826019A0 (it) 1978-07-24
DK144128C (da) 1982-05-17
PH14642A (en) 1981-10-12
NL7807507A (nl) 1979-01-29
MC1199A1 (fr) 1979-03-19
CS203014B2 (en) 1981-02-27
NZ187921A (en) 1981-03-16
SE7808111L (sv) 1979-01-26
DK328978A (da) 1979-01-26
FI63409B (fi) 1983-02-28
AU519688B2 (en) 1981-12-17
FI63409C (fi) 1983-06-10
PT68342A (en) 1978-08-01
CA1094555A (en) 1981-01-27
AR218500A1 (es) 1980-06-13

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