CS200232B2 - Process for preparing 4-substituted imidazo 1,2-a-quinoxalines - Google Patents

Process for preparing 4-substituted imidazo 1,2-a-quinoxalines Download PDF

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Publication number
CS200232B2
CS200232B2 CS78169A CS16978A CS200232B2 CS 200232 B2 CS200232 B2 CS 200232B2 CS 78169 A CS78169 A CS 78169A CS 16978 A CS16978 A CS 16978A CS 200232 B2 CS200232 B2 CS 200232B2
Authority
CS
Czechoslovakia
Prior art keywords
group
alkyl
formula
compound
starting material
Prior art date
Application number
CS78169A
Other languages
Czech (cs)
English (en)
Inventor
Paul L Warner
Edward J Luber
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CS200232B2 publication Critical patent/CS200232B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CS78169A 1977-01-07 1978-01-09 Process for preparing 4-substituted imidazo 1,2-a-quinoxalines CS200232B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75764077A 1977-01-07 1977-01-07

Publications (1)

Publication Number Publication Date
CS200232B2 true CS200232B2 (en) 1980-08-29

Family

ID=25048641

Family Applications (1)

Application Number Title Priority Date Filing Date
CS78169A CS200232B2 (en) 1977-01-07 1978-01-09 Process for preparing 4-substituted imidazo 1,2-a-quinoxalines

Country Status (19)

Country Link
US (1) US4160097A (el)
JP (2) JPS5387398A (el)
AU (1) AU521807B2 (el)
BE (1) BE862608A (el)
CA (1) CA1149385A (el)
CH (2) CH636102A5 (el)
CS (1) CS200232B2 (el)
DE (2) DE2858766C2 (el)
DK (1) DK157024C (el)
FI (1) FI64374C (el)
FR (1) FR2376858A1 (el)
GB (2) GB1579499A (el)
GR (1) GR73168B (el)
IE (1) IE46191B1 (el)
LU (1) LU78813A1 (el)
NL (1) NL7800114A (el)
SE (2) SE436359B (el)
YU (1) YU44663B (el)
ZA (1) ZA7827B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439308B (sv) * 1978-08-02 1985-06-10 Roussel Uclaf Imidazo(1,2-a)kinoxaliner och farmaceutiska kompositioner derav
JPS5569567A (en) * 1978-11-21 1980-05-26 Eisai Co Ltd Novel imidazole compound, and antidepressant containing the same
IT1209431B (it) * 1980-11-28 1989-07-16 Angeli Inst Spa Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
JPH0349309U (el) * 1989-09-21 1991-05-14
US6235740B1 (en) 1997-08-25 2001-05-22 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
US6635626B1 (en) 1997-08-25 2003-10-21 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
CN1285834A (zh) 1997-11-11 2001-02-28 小野药品工业株式会社 稠合吡嗪化合物
DE69940808D1 (de) * 1998-03-04 2009-06-10 Bristol Myers Squibb Co Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
US6869956B2 (en) * 2000-10-03 2005-03-22 Bristol-Myers Squibb Company Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
DE60117835T2 (de) 2000-10-03 2006-10-19 Bristol-Myers Squibb Co. Amino- substituierte tetracyclische Verbindungen,die als entzündungshemmende Mittel nützlich sind, und diese enthaltende Arzneimittel
CA2436770A1 (en) * 2001-02-01 2002-08-08 James R. Burke Methods of treating inflammatory and immune diseases using inhibitors of ikb kinase (ikk)
EP2066642A1 (en) * 2006-09-25 2009-06-10 Arete Therapeutics, INC. Soluble epoxide hydrolase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541109A (en) * 1968-06-25 1970-11-17 Du Pont 1-substituted imidazoles useful in acth reserve assay
US4011236A (en) * 1968-09-09 1977-03-08 Merck & Co., Inc. N-(benzimidazol-2-yl)arylcarboxamides as ultraviolet (uv) light absorbers
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
US3994893A (en) * 1975-11-03 1976-11-30 E. R. Squibb & Sons, Inc. 4-Amino derivatives of pyrozolo[1,5-a]quinoxaline-3-carboxylic acid and esters

Also Published As

Publication number Publication date
FI64374B (fi) 1983-07-29
FR2376858B1 (el) 1980-10-24
FI64374C (fi) 1983-11-10
CA1149385A (en) 1983-07-05
JPS5387398A (en) 1978-08-01
DK157024B (da) 1989-10-30
DK4278A (da) 1978-07-08
SE7800138L (sv) 1978-07-08
JPH0130825B2 (el) 1989-06-22
JPS61171470A (ja) 1986-08-02
FR2376858A1 (fr) 1978-08-04
JPS6259110B2 (el) 1987-12-09
DK157024C (da) 1990-04-02
ZA7827B (en) 1979-01-31
SE436359B (sv) 1984-12-03
LU78813A1 (fr) 1978-09-18
DE2858766C2 (el) 1990-04-05
SE8300945D0 (sv) 1983-02-21
GB1579498A (en) 1980-11-19
AU3233178A (en) 1979-07-19
IE46191B1 (en) 1983-03-23
NL7800114A (nl) 1978-07-11
BE862608A (fr) 1978-07-03
SE8300945L (sv) 1983-02-21
CH636102A5 (fr) 1983-05-13
AU521807B2 (en) 1982-04-29
US4160097A (en) 1979-07-03
YU2178A (en) 1990-04-30
CH640229A5 (fr) 1983-12-30
GB1579499A (en) 1980-11-19
SE460477B (sv) 1989-10-16
DE2800480A1 (de) 1978-07-13
FI780023A (fi) 1978-07-08
IE780037L (en) 1978-07-07
GR73168B (el) 1984-02-14
YU44663B (en) 1990-12-31
DE2800480C2 (el) 1990-04-12

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