FI64374C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-ubstituerade imidazo(1,2-a)kinoxaliner - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-ubstituerade imidazo(1,2-a)kinoxaliner Download PDF

Info

Publication number
FI64374C
FI64374C FI780023A FI780023A FI64374C FI 64374 C FI64374 C FI 64374C FI 780023 A FI780023 A FI 780023A FI 780023 A FI780023 A FI 780023A FI 64374 C FI64374 C FI 64374C
Authority
FI
Finland
Prior art keywords
phenyl
carbon atoms
compounds
alkyl
compound
Prior art date
Application number
FI780023A
Other languages
English (en)
Finnish (fi)
Other versions
FI64374B (fi
FI780023A (fi
Inventor
Jr Paul L Warner
Jr Edward J Luber
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI780023A publication Critical patent/FI780023A/fi
Priority to FI821308A priority Critical patent/FI64375C/fi
Publication of FI64374B publication Critical patent/FI64374B/fi
Application granted granted Critical
Publication of FI64374C publication Critical patent/FI64374C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI780023A 1977-01-07 1978-01-04 Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-ubstituerade imidazo(1,2-a)kinoxaliner FI64374C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI821308A FI64375C (fi) 1977-01-07 1982-04-14 Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-ubstituerade imidazo(1,2-a)kinoxaliner

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75764077A 1977-01-07 1977-01-07
US75764077 1977-01-07

Publications (3)

Publication Number Publication Date
FI780023A FI780023A (fi) 1978-07-08
FI64374B FI64374B (fi) 1983-07-29
FI64374C true FI64374C (fi) 1983-11-10

Family

ID=25048641

Family Applications (1)

Application Number Title Priority Date Filing Date
FI780023A FI64374C (fi) 1977-01-07 1978-01-04 Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-ubstituerade imidazo(1,2-a)kinoxaliner

Country Status (19)

Country Link
US (1) US4160097A (el)
JP (2) JPS5387398A (el)
AU (1) AU521807B2 (el)
BE (1) BE862608A (el)
CA (1) CA1149385A (el)
CH (2) CH636102A5 (el)
CS (1) CS200232B2 (el)
DE (2) DE2858766C2 (el)
DK (1) DK157024C (el)
FI (1) FI64374C (el)
FR (1) FR2376858A1 (el)
GB (2) GB1579499A (el)
GR (1) GR73168B (el)
IE (1) IE46191B1 (el)
LU (1) LU78813A1 (el)
NL (1) NL7800114A (el)
SE (2) SE436359B (el)
YU (1) YU44663B (el)
ZA (1) ZA7827B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439308B (sv) * 1978-08-02 1985-06-10 Roussel Uclaf Imidazo(1,2-a)kinoxaliner och farmaceutiska kompositioner derav
JPS5569567A (en) * 1978-11-21 1980-05-26 Eisai Co Ltd Novel imidazole compound, and antidepressant containing the same
IT1209431B (it) * 1980-11-28 1989-07-16 Angeli Inst Spa Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
JPH0349309U (el) * 1989-09-21 1991-05-14
US6235740B1 (en) 1997-08-25 2001-05-22 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
US6635626B1 (en) 1997-08-25 2003-10-21 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
CN1285834A (zh) 1997-11-11 2001-02-28 小野药品工业株式会社 稠合吡嗪化合物
DE69940808D1 (de) * 1998-03-04 2009-06-10 Bristol Myers Squibb Co Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
US6869956B2 (en) * 2000-10-03 2005-03-22 Bristol-Myers Squibb Company Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
DE60117835T2 (de) 2000-10-03 2006-10-19 Bristol-Myers Squibb Co. Amino- substituierte tetracyclische Verbindungen,die als entzündungshemmende Mittel nützlich sind, und diese enthaltende Arzneimittel
CA2436770A1 (en) * 2001-02-01 2002-08-08 James R. Burke Methods of treating inflammatory and immune diseases using inhibitors of ikb kinase (ikk)
EP2066642A1 (en) * 2006-09-25 2009-06-10 Arete Therapeutics, INC. Soluble epoxide hydrolase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541109A (en) * 1968-06-25 1970-11-17 Du Pont 1-substituted imidazoles useful in acth reserve assay
US4011236A (en) * 1968-09-09 1977-03-08 Merck & Co., Inc. N-(benzimidazol-2-yl)arylcarboxamides as ultraviolet (uv) light absorbers
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
US3994893A (en) * 1975-11-03 1976-11-30 E. R. Squibb & Sons, Inc. 4-Amino derivatives of pyrozolo[1,5-a]quinoxaline-3-carboxylic acid and esters

Also Published As

Publication number Publication date
FI64374B (fi) 1983-07-29
FR2376858B1 (el) 1980-10-24
CA1149385A (en) 1983-07-05
JPS5387398A (en) 1978-08-01
DK157024B (da) 1989-10-30
DK4278A (da) 1978-07-08
SE7800138L (sv) 1978-07-08
JPH0130825B2 (el) 1989-06-22
JPS61171470A (ja) 1986-08-02
FR2376858A1 (fr) 1978-08-04
JPS6259110B2 (el) 1987-12-09
DK157024C (da) 1990-04-02
ZA7827B (en) 1979-01-31
SE436359B (sv) 1984-12-03
LU78813A1 (fr) 1978-09-18
DE2858766C2 (el) 1990-04-05
SE8300945D0 (sv) 1983-02-21
GB1579498A (en) 1980-11-19
AU3233178A (en) 1979-07-19
CS200232B2 (en) 1980-08-29
IE46191B1 (en) 1983-03-23
NL7800114A (nl) 1978-07-11
BE862608A (fr) 1978-07-03
SE8300945L (sv) 1983-02-21
CH636102A5 (fr) 1983-05-13
AU521807B2 (en) 1982-04-29
US4160097A (en) 1979-07-03
YU2178A (en) 1990-04-30
CH640229A5 (fr) 1983-12-30
GB1579499A (en) 1980-11-19
SE460477B (sv) 1989-10-16
DE2800480A1 (de) 1978-07-13
FI780023A (fi) 1978-07-08
IE780037L (en) 1978-07-07
GR73168B (el) 1984-02-14
YU44663B (en) 1990-12-31
DE2800480C2 (el) 1990-04-12

Similar Documents

Publication Publication Date Title
FI64374C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-ubstituerade imidazo(1,2-a)kinoxaliner
US6281220B1 (en) Deazapurine derivatives; a new class of CRF1 specific ligands
EP3621960B1 (en) Thienopyridines and benzothiophenes useful as irak4 inhibitors
JP5649614B2 (ja) 有機化合物
GB2182930A (en) Condensed imidazopyridine derivatives
DE69232323T2 (de) Verwendung von Adenosinantagonisten zur Vorbeugung und Behandlung von Pankreatitis und Ulcera
CA3070621A1 (en) Tyk2 inhibitors and uses thereof
CN110944994B (zh) 作为腺苷受体拮抗剂的喹喔啉衍生物
EP0590428A1 (de) Azachinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung
BR112016027679B1 (pt) Inibidores de proteína quinase, seu usos e seus métodos de fabricação, kit e composição farmacêutica
CN108463222B (zh) 用于治疗疾病的杂环化合物
EP3560921B1 (en) Quinazoline compound, preparation method, application as pi3k inhibitor for the treatment of cancer, and pharmaceutical compostion thereof
US4782055A (en) Imidazopyridine compounds useful in the treatment of ulcers
FI79321B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(hydroximetyl)-1,6,7,11b-tetrahydro-2h,4h- /1,3/oxazino- eller tiazino/4,3-a/isokinolinderivat.
US5644057A (en) Deazapurine derivatives; a new class of CRF1 specific ligands
WO2023279938A1 (zh) 2,6,8-多取代咪唑并[1,2-a]吡嗪及其合成方法和应用
EP3224248B1 (en) Certain protein kinase inhibitors
CN112912142B (zh) 作为腺苷受体拮抗剂的5-氮杂吲唑衍生物
MX2015001905A (es) Azaheterociclos como inhibidores de bir2 y/o bir3.
CN110997662B (zh) 作为腺苷受体拮抗剂的苯并咪唑衍生物
CS238624B2 (en) Production method of chinoline derivatives
CN108218874B (zh) 一种磷酸二酯酶抑制剂及其用途
AU2005236046A1 (en) Clopidogrel salt and polymorphic forms thereof
AU2017280412B2 (en) Substituted pyrrolo (2, 3-D) pyridazin-4-ones and pyrazolo (3, 4-D) pyridazin-4-ones as protein kinase inhibitors
Edelman et al. Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: BRISTOL-MYERS CO