CO6541613A2 - Combinaciones de un antagonista de los receptores muscarínicos y un agonista del adreno-receptor beta 2 - Google Patents

Combinaciones de un antagonista de los receptores muscarínicos y un agonista del adreno-receptor beta 2

Info

Publication number
CO6541613A2
CO6541613A2 CO12088319A CO12088319A CO6541613A2 CO 6541613 A2 CO6541613 A2 CO 6541613A2 CO 12088319 A CO12088319 A CO 12088319A CO 12088319 A CO12088319 A CO 12088319A CO 6541613 A2 CO6541613 A2 CO 6541613A2
Authority
CO
Colombia
Prior art keywords
beta
combinations
antagonist
adreno
muscarinic
Prior art date
Application number
CO12088319A
Other languages
English (en)
Inventor
Darrell Baker
Mark Bruce
Patrick Wire
Marian Thomas
Brian Noga
Glenn Crater
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41573013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6541613(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO6541613A2 publication Critical patent/CO6541613A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Se proporcionan combinaciones novedosas de un antagonista de los receptores muscarínicos de acetil-colina y un agonista beta-2 para su administración inhalada por medio de la nariz o la boca, y métodos para su uso.
CO12088319A 2009-12-01 2012-05-28 Combinaciones de un antagonista de los receptores muscarínicos y un agonista del adreno-receptor beta 2 CO6541613A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0921075.8A GB0921075D0 (en) 2009-12-01 2009-12-01 Novel combination of the therapeutic agents

Publications (1)

Publication Number Publication Date
CO6541613A2 true CO6541613A2 (es) 2012-10-16

Family

ID=41573013

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12088319A CO6541613A2 (es) 2009-12-01 2012-05-28 Combinaciones de un antagonista de los receptores muscarínicos y un agonista del adreno-receptor beta 2

Country Status (40)

Country Link
US (7) US20120309725A1 (es)
EP (2) EP2506844B1 (es)
JP (1) JP5816631B2 (es)
KR (2) KR101742140B1 (es)
CN (2) CN102724974A (es)
AU (6) AU2010326798B2 (es)
BR (1) BR112012012925A2 (es)
CA (1) CA2781487C (es)
CL (1) CL2012001432A1 (es)
CO (1) CO6541613A2 (es)
CR (1) CR20120265A (es)
CY (2) CY1120058T1 (es)
DK (1) DK2506844T3 (es)
DO (1) DOP2012000148A (es)
EA (1) EA023839B1 (es)
ES (1) ES2659330T3 (es)
FR (1) FR18C1022I2 (es)
GB (1) GB0921075D0 (es)
HK (1) HK1249407A1 (es)
HR (1) HRP20180312T1 (es)
HU (2) HUE036216T2 (es)
IL (1) IL219893A (es)
LT (2) LT2506844T (es)
LU (1) LUC00077I2 (es)
MA (1) MA33853B1 (es)
ME (1) ME02965B (es)
MX (1) MX351290B (es)
MY (1) MY184864A (es)
NO (1) NO2506844T3 (es)
NZ (1) NZ600026A (es)
PE (2) PE20130042A1 (es)
PL (1) PL2506844T3 (es)
PT (1) PT2506844T (es)
RS (1) RS56848B1 (es)
SG (2) SG181087A1 (es)
SI (1) SI2506844T1 (es)
TR (1) TR201802921T4 (es)
UA (1) UA106775C2 (es)
WO (1) WO2011067212A1 (es)
ZA (1) ZA201203890B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY28871A1 (es) 2004-04-27 2005-11-30 Glaxo Group Ltd Antagonistas del receptor de acetilcolina muscarinico
SI2400950T1 (sl) 2009-02-26 2019-09-30 Glaxo Group Limited Farmacevtske forlmulacije, ki obsegajo 4-((1 R)-2-((6-(2-((2,6- diklorobenzil)oksi)etoksi)heksil)amino)-1-hidroksietil)-2- (hidroksimetil)fenol
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
WO2012028663A1 (en) * 2010-08-31 2012-03-08 Glaxo Group Limited Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same
MX2013014399A (es) * 2011-06-08 2014-03-21 Glaxo Group Ltd Combinacion que comprende umeclidinio y un corticosteroide.
CN103561731A (zh) * 2011-06-08 2014-02-05 葛兰素集团有限公司 包含芜地溴铵的干粉吸入器组合物
ES2814336T3 (es) * 2012-04-13 2021-03-26 Glaxosmithkline Ip Dev Ltd Partículas de agregado
GB201222679D0 (en) * 2012-12-17 2013-01-30 Glaxo Group Ltd Pharmaceutical combination products
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
ES2959699T3 (es) * 2014-05-28 2024-02-27 Glaxosmithkline Ip Dev Ltd Furoato de fluticasona en el tratamiento de la EPOC
TR201407010A2 (tr) 2014-06-16 2015-12-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Vilanterol formülasyonları.
EP2957552B1 (en) 2014-06-16 2020-01-22 Arven Ilac Sanayi Ve Ticaret A.S. Vilanterol formulations
CA2952760A1 (en) 2014-06-18 2015-12-23 Cipla Limited Pharmaceutical composition comprising a beta-2-agonist and anticholinergic agent
WO2020100040A1 (en) * 2018-11-12 2020-05-22 3M Innovative Properties Company Umeclidinium and vilanterol formulation and inhaler
CN111840256A (zh) * 2019-04-29 2020-10-30 上海谷森医药有限公司 一种雾化吸入剂及其制备方法
WO2020237151A1 (en) 2019-05-23 2020-11-26 Huang Cai Gu Inhalable formulation of a solution containing vilanterol trifenatate and umeclidinium bromide
WO2021252577A1 (en) * 2020-06-09 2021-12-16 Anovent Pharmaceutical (U.S.), Llc Pharmaceutical formulation containing umeclidinium bromide and vilanterol trifenatate

Family Cites Families (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB124009A (en) 1918-01-12 1919-03-12 Walter Edward Kimber Improvements in and connected with the Manufacture of Tools for Turning, Planing, Boring and similar purposes.
GB124010A (en) 1919-01-10 1919-03-20 Rene Emile Dior Improved Process for the Manufacture of Synthetic Resins.
GB1242211A (en) 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
GB1381872A (en) 1971-06-22 1975-01-29 Fisons Ltd Pharmaceutical compositions for inhalation
GB1424432A (en) 1972-03-25 1976-02-11 Degussa Pharmaceutical compositions
GB2064336B (en) 1979-12-06 1984-03-14 Glaxo Group Ltd Device for dispensing medicaments
ATE23272T1 (de) 1981-07-08 1986-11-15 Draco Ab Pulverinhalator.
GB2169265B (en) 1982-10-08 1987-08-12 Glaxo Group Ltd Pack for medicament
AU570013B2 (en) 1982-10-08 1988-03-03 Glaxo Group Limited Medicament inhaler
US4778054A (en) 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
AU591152B2 (en) 1985-07-30 1989-11-30 Glaxo Group Limited Devices for administering medicaments to patients
GB8530365D0 (en) 1985-12-10 1986-01-22 Univ Bath Manufacture of moulded products
IT1204826B (it) 1986-03-04 1989-03-10 Chiesi Farma Spa Composizioni farmaceutiche per inalazione
CA1329526C (en) 1987-08-20 1994-05-17 Hiroshi Ikura Powdery medicine applicator device
US4994276A (en) 1988-09-19 1991-02-19 Edward Mendell Co., Inc. Directly compressible sustained release excipient
GB8820353D0 (en) 1988-08-26 1988-09-28 Staniforth J N Controlled release tablet
US5135757A (en) 1988-09-19 1992-08-04 Edward Mendell Co., Inc. Compressible sustained release solid dosage forms
US5376386A (en) 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
HU213221B (en) 1990-03-02 1997-03-28 Glaxo Group Ltd Inhalation device and medicine packet for device
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
UA26230A (uk) 1990-03-02 1999-07-19 Глексо Груп Лімітед Іhгалятор для спільhого використаhhя з лікувальhим блоком і лікувальhий блок
FR2660634B1 (fr) 1990-04-06 1992-10-16 Airsec Ind Sa Conditionnement pour produits necessitant l'usage d'un agent deshydratant.
JPH0471560A (ja) 1990-07-10 1992-03-06 Mect Corp 包装体
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE4140689B4 (de) 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
EP0611567B1 (en) 1992-06-12 2002-08-28 Teijin Limited Ultrafine powder for inhalation and production thereof
EP0606486B1 (en) 1992-06-12 2001-08-29 Teijin Limited Pharmaceutical preparation for intra-airway administration
GB2269992A (en) 1992-08-14 1994-03-02 Rh Ne Poulenc Rorer Limited Powder inhalation formulations
CA2144163A1 (en) 1992-09-09 1994-03-17 Fisons Limited Pharmaceutical packaging
SE9203743D0 (sv) 1992-12-11 1992-12-11 Astra Ab Efficient use
UA27961C2 (uk) 1992-12-18 2000-10-16 Шерінг Корпорейшн Інгалятор для порошкових ліків
US5441060A (en) 1993-02-08 1995-08-15 Duke University Dry powder delivery system
DE69413955T2 (de) 1993-03-17 1999-04-01 Minnesota Mining & Mfg Aerosolzusammensetzung enthaltend einen aus ester-, amid- oder merkaptoester- derivat dispergiermittel
US5730785A (en) 1993-04-01 1998-03-24 Multisorb Technologies, Inc. Desiccant canister for desiccants and other particulate material
US5506203C1 (en) 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
DE4323636A1 (de) 1993-07-15 1995-01-19 Hoechst Ag Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5503662A (en) 1994-03-29 1996-04-02 Multiform Desiccants, Inc. Canister with porous plastic ends
FI95441C (fi) 1994-05-31 1996-02-12 Leiras Oy Inhalointilaitteen lääkeainekammio
US6156231A (en) 1994-09-08 2000-12-05 Multisorb Technologies, Inc. Oxygen absorbing composition with cover layer
US5641425A (en) 1994-09-08 1997-06-24 Multiform Desiccants, Inc. Oxygen absorbing composition
SA95160463B1 (ar) 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US6279736B1 (en) 1995-04-19 2001-08-28 Capitol Specialty Plastics, Inc. Barrier pack having an absorbing agent applied to the interior of the pack
CN1185139A (zh) 1995-04-19 1998-06-17 金圆玻璃容器有限公司 包含在封闭容器内的干燥材料
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
GB9700226D0 (en) 1997-01-08 1997-02-26 Glaxo Group Ltd Inhalation device
US6103141A (en) 1997-01-23 2000-08-15 Multisorb Technologies, Inc. Desiccant deposit
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
WO1998040169A1 (en) 1997-03-14 1998-09-17 The University Of Houston Methods for making fluorinated surface modifying agents, methods of using same and products made using same
US5985415A (en) 1997-11-17 1999-11-16 Reconnx, Inc. Finger joint architecture for wood products, and method and apparatus for formation thereof
US6086376A (en) 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
CA2319736C (en) 1998-02-05 2009-01-27 E.I. Du Pont De Nemours And Company Water purification apparatus
HUP0101608A2 (hu) 1998-04-18 2002-03-28 Glaxo Group Limited Aeroszol formájú gyógyszerkészítmény és eljárás előállítására
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
ATE382386T1 (de) 1998-11-13 2008-01-15 Jagotec Ag Multidosis-trockenpulverinhalator mit pulverreservoir
US20070212422A1 (en) 1999-11-10 2007-09-13 Manfred Keller Dry powder for inhalation
GB9827145D0 (en) 1998-12-09 1999-02-03 Co Ordinated Drug Dev Improvements in or relating to powders
US6352152B1 (en) 1998-12-18 2002-03-05 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US6390291B1 (en) 1998-12-18 2002-05-21 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
US6119853A (en) 1998-12-18 2000-09-19 Glaxo Wellcome Inc. Method and package for storing a pressurized container containing a drug
US6315112B1 (en) 1998-12-18 2001-11-13 Smithkline Beecham Corporation Method and package for storing a pressurized container containing a drug
WO2001097888A2 (en) 2000-06-22 2001-12-27 Glaxo Group Limited Method and package for storing a pressurized container containing a drug
EP1158958B1 (en) 1999-03-05 2007-06-06 CHIESI FARMACEUTICI S.p.A. Improved powdery pharmaceutical compositions for inhalation
IT1309592B1 (it) 1999-03-05 2002-01-24 Chiesi Farma Spa Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e
USD440874S1 (en) 1999-07-29 2001-04-24 The Gillette Company Container
ATE259868T1 (de) 1999-10-11 2004-03-15 Innovata Biomed Ltd Medikamentenabgabevorrichtung mit einer feuchtigkeitsbeständigen beschichtung
DE19957802A1 (de) 1999-12-01 2001-06-07 Trw Repa Gmbh Gurtaufrollersystem
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
JP2003531123A (ja) 2000-04-13 2003-10-21 イノバータ・バイオミッド・リミテッド 医薬品
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
WO2001087731A2 (en) 2000-05-15 2001-11-22 Glaxo Group Limited Aerosol mdi overcap containing desiccant
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
AU2001275760B2 (en) 2000-08-05 2005-03-17 Glaxo Group Limited 6.alpha., 9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl) oxy!-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid S-fluoromethyl ester as an anti-inflammatory agent
DE10056855A1 (de) 2000-11-16 2002-05-29 Lohmann Therapie Syst Lts Verbundlaminat mit Sauerstoff und Feuchtigkeit absorbierender Schicht und Verfahren zu seiner Herstellung
WO2002043700A2 (en) 2000-11-30 2002-06-06 Vectura Limited Particles for use in a pharmaceutical composition
EP2298279B1 (en) 2000-11-30 2018-11-14 Vectura Limited Pharmaceutical compositions for inhalation
EP1241110A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Dispensing unit for oxygen-sensitive drugs
EP1243524A3 (en) 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
DE10126924A1 (de) 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
BRPI0212455B8 (pt) * 2001-09-14 2021-05-25 Glaxo Group Ltd composto derivado de fenetanolamina para o tratamento de doenças respiratórias, formulação farmacêutica, combinação, e, uso do mesmo
WO2003057593A1 (en) 2001-12-21 2003-07-17 Nektar Therapeutics Capsule package with moisture barrier
GB0201677D0 (en) 2002-01-25 2002-03-13 Glaxo Group Ltd Medicament dispenser
GB0208608D0 (en) * 2002-04-13 2002-05-22 Glaxo Group Ltd Composition
US20030203141A1 (en) 2002-04-25 2003-10-30 Blum John B. Blister package
US20030235664A1 (en) 2002-06-20 2003-12-25 Rick Merical Films having a desiccant material incorporated therein and methods of use and manufacture
US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
US20040131805A1 (en) 2002-06-20 2004-07-08 Merical Rick L. Films having a desiccant material incorporated therein and methods of use and manufacture
US20060269708A1 (en) 2002-06-20 2006-11-30 Rick Merical Films having a desiccant material incorporated therein and methods of use and manufacture
US20060236868A1 (en) 2003-05-19 2006-10-26 Bester Pansegrouw Dessicant container
GB0312148D0 (en) 2003-05-28 2003-07-02 Aventis Pharma Ltd Stabilized pharmaceutical products
SE527191C2 (sv) 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av tiotropium och fluticason
GB0315889D0 (en) 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
EP1641437A4 (en) 2003-07-09 2009-06-03 Chong Kun Dang Pharm Corp SOLID DISPERSION OF TACROLIMUS
GB0316341D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Pharmaceutical formulations
WO2005004845A1 (en) 2003-07-11 2005-01-20 Glaxo Group Limited Pharmaceutical formulations comprising magnesium stearate
US20050072958A1 (en) 2003-10-02 2005-04-07 Thomas Powers Oxygen scavenger for low moisture environment and methods of using the same
AR046103A1 (es) * 2003-10-14 2005-11-23 Glaxo Group Ltd Compuesto de 8-azoniabiciclo [3.2.1] octano,composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos y uso del compuesto para preparar dicha composicion
WO2005044186A2 (en) 2003-10-28 2005-05-19 Glaxo Group Limited Inhalable pharmaceutical formulations employing desiccating agents and methods of administering the same
GB0326632D0 (en) * 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
SE0303270L (sv) 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303569L (sv) 2003-12-03 2005-06-04 Microdrug Ag DPI för avlämning av fuktkänsliga medikament
EP1691782A1 (en) 2003-12-03 2006-08-23 Microdrug AG Medical product containing tiotropium
SE0303269L (sv) 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
JP2007512898A (ja) 2003-12-03 2007-05-24 マイクロドラッグ アクチェンゲゼルシャフト 湿度に過敏な薬剤向けの予め計量されたドライパウダー吸入器
GB2410192B (en) 2004-01-23 2005-12-07 Eg Technology Ltd An inhaler
UY28871A1 (es) 2004-04-27 2005-11-30 Glaxo Group Ltd Antagonistas del receptor de acetilcolina muscarinico
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
RU2379033C2 (ru) 2004-05-31 2010-01-20 Лабораториос Альмираль, С.А. Комбинации, содержащие антимускариновые средства и бета-адренергические агонисты
ES2257152B1 (es) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
SE530006C2 (sv) 2004-06-18 2008-02-05 Mederio Ag Inhalator som använder balja
SE0401654D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab A support structure for a medicament
GB0416397D0 (en) 2004-07-22 2004-08-25 Glaxo Group Ltd Pharmaceutical formulations
JP2008510014A (ja) 2004-08-16 2008-04-03 セラヴァンス, インコーポレーテッド β2アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
JP5566576B2 (ja) 2004-10-21 2014-08-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 吸入器用ブリスタ
US7501011B2 (en) 2004-11-09 2009-03-10 Multisorb Technologies, Inc. Humidity control device
SE0402976L (sv) 2004-12-03 2006-06-04 Mederio Ag Medicinsk produkt
PE20061162A1 (es) 2004-12-06 2006-10-14 Smithkline Beecham Corp Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos
PE20060826A1 (es) 2004-12-06 2006-10-08 Smithkline Beecham Corp Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende
WO2006063050A1 (en) 2004-12-08 2006-06-15 Perfecseal, Inc. A sterilizable package with a high barrier to oxygen
JP2008525527A (ja) 2004-12-27 2008-07-17 キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド 脱酸素剤を有していてもよい酸素不浸透性包装の安定化甲状腺ホルモン組成物及び甲状腺ホルモン医薬組成物保管のためのその方法
US20060144733A1 (en) 2004-12-30 2006-07-06 3M Innovative Properties Company Container assembly and method for humidity control
WO2006086130A2 (en) 2005-02-10 2006-08-17 Glaxo Group Limited Process for crystallizing lactose particles for use in pharmaceutical formulations
EP1848444B1 (en) 2005-02-10 2016-11-09 Glaxo Group Limited Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
DE202005002409U1 (de) 2005-02-15 2005-07-07 Microdrug Ag Inhalierbares Tiotropium und Behälter dafür
DE202005004659U1 (de) 2005-03-22 2005-07-07 Microdrug Ag Vordosierter Trockenpulverinhalator für feuchtigkeitsempfindliche Medikamente
GB0507165D0 (en) 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
JP4659523B2 (ja) 2005-04-26 2011-03-30 共同印刷株式会社 ブリスター用フィルム及びブリスター用包装容器
WO2006124556A2 (en) 2005-05-13 2006-11-23 Glaxo Group Limited Inhalable pharmaceutical formulations employing lactose anhydrate and methods of administering the same
DE102005022862A1 (de) 2005-05-18 2006-12-14 Airsec S.A.S Kapseln für Inhalatoren
GB0523653D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
US20060278965A1 (en) 2005-06-10 2006-12-14 Foust Donald F Hermetically sealed package and methods of making the same
GB0515584D0 (en) 2005-07-28 2005-09-07 Glaxo Group Ltd Medicament dispenser
CA2623658A1 (en) 2005-09-28 2007-04-05 Mederio Ag Inhaler device for moisture sensitive drugs and method of operating an inhaler device
GB0520794D0 (en) 2005-10-12 2005-11-23 Innovata Biomed Ltd Inhaler
DE502005006831D1 (de) 2005-10-18 2009-04-23 Alcan Tech & Man Ltd Kaltverformbares Laminat für Blisterbodenteile
EP1787800A1 (de) 2005-11-17 2007-05-23 Alcan Technology & Management Ltd. Kaltverformbares Laminat für Blisterbodenteile
AR058289A1 (es) 2005-12-12 2008-01-30 Glaxo Group Ltd Colector para ser usado en dispensador de medicamento
US20090012132A1 (en) 2006-02-27 2009-01-08 Takeda Pharmaceutical Company Limited Pharmaceutical Package
KR100764640B1 (ko) 2006-03-08 2007-10-10 세원셀론텍(주) 지방조직 수복용 키트
US20090308772A1 (en) 2006-03-17 2009-12-17 Abrams William S Moisture-tight primary packaging for a dry powder inhaler
CA2646236A1 (en) 2006-03-22 2007-09-27 Glaxo Group Limited Novel formulations
CA2646578A1 (en) 2006-03-22 2007-10-18 3M Innovative Properties Company Novel formulations
AU2006341188A1 (en) 2006-03-24 2007-10-04 Ian Simon Tracton Stable packaged dosage form and process therefor
WO2007135024A1 (en) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh New long-acting drug combinations for the treatment of respiratory diseases
GB0615108D0 (en) 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
US20090314664A1 (en) 2006-08-03 2009-12-24 Merck Patent Gmbh Pack Containing Pharmaceutical Administration Forms
US20090298742A1 (en) 2006-08-09 2009-12-03 Glaxo Group Limited Process for manufacturing lactose
WO2008021142A2 (en) 2006-08-09 2008-02-21 Glaxo Group Limited Process for manufacturing lactose
FI20065636A0 (fi) 2006-10-04 2006-10-04 Lab Pharma Ltd Dessikanttijärjestelmä irtohaloitavien jauheiden kosteuden säätämiseksi
US20100099651A1 (en) 2006-10-26 2010-04-22 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
US20080178559A1 (en) 2007-01-26 2008-07-31 Multisorb Technologies, Inc. Sorbent Packaging
US8034739B2 (en) 2007-03-29 2011-10-11 Multisorb Technologies, Inc. Method for selecting adsorptive composite barriers for packaging applications
US7549272B2 (en) 2007-04-16 2009-06-23 Multisorb Technologies, Inc. Sorbent canister with beveled edges
US20100319303A1 (en) 2007-05-07 2010-12-23 Airsec Container with moisture control capacity
UY31233A1 (es) 2007-07-21 2009-03-02 Unidades de envasado con un agente desecante
PE20090907A1 (es) 2007-07-21 2009-08-05 Boehringer Ingelheim Int Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente
WO2009029029A1 (en) 2007-08-24 2009-03-05 Astrazeneca Ab Inhaler for powdered substances with desiccant compartment
KR20100063116A (ko) 2007-09-12 2010-06-10 글락소 그룹 리미티드 치료제들의 복합제
EP2080523A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
EP2254630A1 (de) 2008-02-20 2010-12-01 Boehringer Ingelheim International GmbH Pulverinhalatoren
JP4983657B2 (ja) 2008-03-11 2012-07-25 富士通株式会社 電子メール管理プログラム、該プログラムを記録した記録媒体、通信端末、および電子メール管理方法
EP2127628A1 (en) 2008-05-27 2009-12-02 Ranbaxy Laboratories Limited Unit dose pack
US9095324B2 (en) 2008-06-20 2015-08-04 Boston Scientific Scimed, Inc. Package assembly
PE20110598A1 (es) 2008-10-02 2011-08-31 Respivert Ltd Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
WO2010097114A1 (en) 2009-02-26 2010-09-02 Glaxo Group Limited Novel combination of therapeutic agents
SI2400950T1 (sl) * 2009-02-26 2019-09-30 Glaxo Group Limited Farmacevtske forlmulacije, ki obsegajo 4-((1 R)-2-((6-(2-((2,6- diklorobenzil)oksi)etoksi)heksil)amino)-1-hidroksietil)-2- (hidroksimetil)fenol
US8985102B2 (en) 2009-05-18 2015-03-24 Adamis Pharmaceuticals Corporation Dry powder inhalers
DK2277799T3 (da) 2009-07-23 2012-05-21 Airsec Sas Hydreret fugtighedsbekæmpelsesstof og fremgangsmåde til fremstilling deraf
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
WO2012028663A1 (en) 2010-08-31 2012-03-08 Glaxo Group Limited Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same
MX2013014399A (es) 2011-06-08 2014-03-21 Glaxo Group Ltd Combinacion que comprende umeclidinio y un corticosteroide.
CN103561731A (zh) 2011-06-08 2014-02-05 葛兰素集团有限公司 包含芜地溴铵的干粉吸入器组合物
GB201222679D0 (en) 2012-12-17 2013-01-30 Glaxo Group Ltd Pharmaceutical combination products

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