CO6351752A2 - Antagonistas de pcsk9 - Google Patents

Antagonistas de pcsk9

Info

Publication number
CO6351752A2
CO6351752A2 CO11037695A CO11037695A CO6351752A2 CO 6351752 A2 CO6351752 A2 CO 6351752A2 CO 11037695 A CO11037695 A CO 11037695A CO 11037695 A CO11037695 A CO 11037695A CO 6351752 A2 CO6351752 A2 CO 6351752A2
Authority
CO
Colombia
Prior art keywords
antibodies
pcsk9
treatment
invention further
antigen binding
Prior art date
Application number
CO11037695A
Other languages
English (en)
Inventor
Hong Liang
Yasmina Noubia Abdiche
Riggers Javier Fernando Chaparro
Bruce Charles Gomes
Julie Li Hawkins
Original Assignee
Rinat Neuroscience Corppration
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rinat Neuroscience Corppration, Pfizer filed Critical Rinat Neuroscience Corppration
Publication of CO6351752A2 publication Critical patent/CO6351752A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona anticuerpos antagonizantes, partes de unión a antígeno de los mismos y aptámeros que se unen a proproteína convertasa subtilisina kexina de tipo 9 (PCSK9). También se proporcionan anticuerpos dirigidos a péptidos, uniéndose los anticuerpos a PCSK9. La invención proporciona además un procedimiento para obtener tales anticuerpos y ácido nucleico que codifica anticuerpo. La invención se refiere además a procedimientos terapéuticos para uso de estos anticuerpos y partes de unión a antígeno de los mismos para reducir los niveles de colesterol-LDL y/o para el tratamiento y/o prevención de enfermedad cardiovascular, que incluye el tratamiento de hipercolesterolemia.
CO11037695A 2008-09-12 2011-03-28 Antagonistas de pcsk9 CO6351752A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9671608P 2008-09-12 2008-09-12
US23216109P 2009-08-07 2009-08-07
US23564309P 2009-08-20 2009-08-20

Publications (1)

Publication Number Publication Date
CO6351752A2 true CO6351752A2 (es) 2011-12-20

Family

ID=42005569

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11037695A CO6351752A2 (es) 2008-09-12 2011-03-28 Antagonistas de pcsk9

Country Status (20)

Country Link
US (5) US8080243B2 (es)
EP (1) EP2344194A2 (es)
JP (4) JP4898976B2 (es)
KR (1) KR101230675B1 (es)
CN (1) CN102333542B (es)
AR (1) AR073292A1 (es)
AU (1) AU2009290438B2 (es)
BR (1) BRPI0919289A2 (es)
CA (1) CA2736349C (es)
CO (1) CO6351752A2 (es)
HK (1) HK1161136A1 (es)
IL (2) IL211519A (es)
MX (1) MX2011002726A (es)
NZ (1) NZ591541A (es)
PE (2) PE20110802A1 (es)
PH (1) PH12014501261B1 (es)
RU (2) RU2528735C2 (es)
TW (2) TWI516501B (es)
WO (1) WO2010029513A2 (es)
ZA (1) ZA201101688B (es)

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* Cited by examiner, † Cited by third party
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JP4898976B2 (ja) 2012-03-21
JP2015205883A (ja) 2015-11-19
IL211519A0 (en) 2011-05-31
JP2013078312A (ja) 2013-05-02
JP5119359B2 (ja) 2013-01-16
MX2011002726A (es) 2011-07-29
JP5750421B2 (ja) 2015-07-22
AU2009290438B2 (en) 2012-12-20
KR20110056317A (ko) 2011-05-26
US20130273069A1 (en) 2013-10-17
US8426363B2 (en) 2013-04-23
JP2012504388A (ja) 2012-02-23
WO2010029513A2 (en) 2010-03-18
ZA201101688B (en) 2012-08-29

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