CO6290664A2 - Piperazinas sustituidas como antagonistas del receptor cb1 - Google Patents

Piperazinas sustituidas como antagonistas del receptor cb1

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Publication number
CO6290664A2
CO6290664A2 CO10007654A CO10007654A CO6290664A2 CO 6290664 A2 CO6290664 A2 CO 6290664A2 CO 10007654 A CO10007654 A CO 10007654A CO 10007654 A CO10007654 A CO 10007654A CO 6290664 A2 CO6290664 A2 CO 6290664A2
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Colombia
Prior art keywords
aryl
heteroaryl
alkyl
group
benzo
Prior art date
Application number
CO10007654A
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English (en)
Inventor
Eric Gilbert
Michael W Miller
Jack D Scott
Duane E Demong
Andrew Stamford
William J Greenlee
Chander Celly
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Intervet Internacional B V
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Publication date
Application filed by Intervet Internacional B V filed Critical Intervet Internacional B V
Publication of CO6290664A2 publication Critical patent/CO6290664A2/es

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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Abstract

1.- Un compuesto de la Fórmula (I):o una sal, solvato. éster, o isómero del mismo farmacéuticamente aceptable, en donde: Ar1 y Ar2 son independientemente arilo o heteroarilo,en donde Ar1 es sustituido con uno o más grupos independientemente seleccionados a partir de Y1 o Y3, yAr2 es sustituido con uno o más grupos independientemente seleccionados a partir de Y1 o Y3; con la condición que cuando Ar2 es piridina o pirimidina, un nitrógeno de dicha piridina o pirimidina no esté en la posición para con relación al punto de unión al anillo de piperazina; siempre y cuando al menos uno de Ar1 o Ar2 es sustituido con al menos un grupo independientemente seleccionados a partir de Y3;n y m son independientemente 0 o 1;A es seleccionado a partir del grupo que consta de -C(O)-, -S(O)2-, -C(=N-OR2)-, y -(C(R2)2)q- en donde q es 1, 2, o 3;B es seleccionado a partir del grupo que consta de - N(R2)-, -C(O)-, y -(C(R3)2) r en donde r es 1, 2 o 3,con la condición que cuando B es - C(O)-, entonces A sea -C(O)- o - (C(R2)2)q-; X es seccionado a partir del grupo que consta de H, alquilo, -S-alquilo, -S(O)2 -alquilo, -S(O)2- cicloalquilo, - S(O)2-arilo, -S(O)2-heteroarilo, cicloalquilo, cicloalquilo benzo-fusionado-, heterocicloalquilo benzo- fusionado, heterocicloalquenilo benzo-fusionado, heterocicloalquilo, -C(R2) =C(R2) - arilo, -C(R2) =C(R2)- heteroarilo, - OR2, - O- alquileno-O- alquilo, - S- arilo, -N(R4)2, -NR4R6, -N(R6)2) - (C(R2) 2)s - heteroarilo, -C(O)- O-alquilo, -O-arilo, -O-heteroarilo, -C(O)arilo, -C(O)- heteroarilo, -N=O, -C(S-alquil) =N- S(O)2- arilo, -C(N(R2)2)=N- S(O) 2 -arilo, y - (C(R2) 2) s -arilo, en donde s es 0, 1, o 2, ...
CO10007654A 2007-06-28 2010-01-26 Piperazinas sustituidas como antagonistas del receptor cb1 CO6290664A2 (es)

Applications Claiming Priority (1)

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US94687307P 2007-06-28 2007-06-28

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CO6290664A2 true CO6290664A2 (es) 2011-06-20

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Country Status (14)

Country Link
US (1) US8623873B2 (es)
EP (2) EP2170846A2 (es)
JP (1) JP2010531361A (es)
KR (1) KR20100051625A (es)
CN (1) CN101796033A (es)
AU (1) AU2008271178A1 (es)
BR (1) BRPI0814806A2 (es)
CA (1) CA2692268A1 (es)
CO (1) CO6290664A2 (es)
MX (1) MX2010000334A (es)
NZ (1) NZ582249A (es)
RU (1) RU2010102478A (es)
WO (1) WO2009005646A2 (es)
ZA (1) ZA201000395B (es)

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CA2822767A1 (en) * 2010-12-23 2012-06-28 Intervet International B.V. Polymorphs of 3-chloro-4[(2r)-2-(4-chlorophenyl)-4-[(1r)-1-(4-cyanophenyl)ethyl]-1-piperazinyl]-benzonitrile, pharmaceutical compositions and method of use comprising said polymorphs, and a process for preparing them
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CN103304561B (zh) * 2013-06-21 2016-06-01 天津药物研究院 一类具有抗血栓作用的化合物
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